Journal of Pharmacology and Experimental Therapeutics: 356 (3)

March 01, 2016; Volume 356,Issue 3

Minireview

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The Utility of Impulsive Bias and Altered Decision Making as Predictors of Drug Efficacy and Target Selection: Rethinking Behavioral Screening for Antidepressant Drugs
Gerard J. Marek, Mark Day and Thomas J. Hudzik

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 534-548; DOI: https://doi.org/10.1124/jpet.115.229922

Behavioral Pharmacology

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Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice
Norikazu Kiguchi, Devki D. Sukhtankar, Huiping Ding, Ken-ichi Tanaka, Shiroh Kishioka, Christopher M. Peters and Mei-Chuan Ko

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 596-603; DOI: https://doi.org/10.1124/jpet.115.229997
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Stereoselective Effects of Abused “Bath Salt” Constituent 3,4-Methylenedioxypyrovalerone in Mice: Drug Discrimination, Locomotor Activity, and Thermoregulation
Brenda M. Gannon, Adrian Williamson, Masaki Suzuki, Kenner C. Rice and William E. Fantegrossi

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 615-623; DOI: https://doi.org/10.1124/jpet.115.229500
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An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund’s Adjuvant Rat Model of Arthritis
F. T. Bonezzi, O. Sasso, S. Pontis, N. Realini, E. Romeo, S. Ponzano, A. Nuzzi, A. Fiasella, F. Bertozzi and D. Piomelli

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 656-663; DOI: https://doi.org/10.1124/jpet.115.230516

Cardiovascular

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Role of Adenosine Receptor(s) in the Control of Vascular Tone in the Mouse Pudendal Artery
Hicham Labazi, Stephen L. Tilley, Catherine Ledent and S. Jamal Mustafa

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 673-680; DOI: https://doi.org/10.1124/jpet.115.230144
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Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in Mice
Vishakantha Murthy, Santiago Reyes, Liyi Geng, Yang Gao and Stephen Brimijoin

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 720-725; DOI: https://doi.org/10.1124/jpet.115.228825

Cellular and Molecular

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20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding
Victor Garcia, Brian Shkolnik, Laura Milhau, John R. Falck and Michal Laniado Schwartzman

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 525-533; DOI: https://doi.org/10.1124/jpet.115.229377
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Alternative Radioligands for Investigating the Molecular Pharmacology of Melatonin Receptors
Céline Legros, Chantal Brasseur, Philippe Delagrange, Pierre Ducrot, Olivier Nosjean and Jean A. Boutin

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 681-692; DOI: https://doi.org/10.1124/jpet.115.229989

Drug Discovery and Translational Medicine

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Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO₂
Jacqueline A. Hannam, Xavier Borrat, Iñaki F. Trocóniz, José F. Valencia, Erik W. Jensen, Angela Pedroso, Jenifer Muñoz, Sergi Castellví-Bel, Antoni Castells and Pedro L. Gambús

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 563-573; DOI: https://doi.org/10.1124/jpet.115.226977
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Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells
Irene Tsilioni, Irwin J. Russell, Julia M. Stewart, Rae M. Gleason and Theoharis C. Theoharides

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 664-672; DOI: https://doi.org/10.1124/jpet.115.230060
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A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat
Carine M. Boustany-Kari, Paul C. Harrison, Hongxing Chen, Kathleen A. Lincoln, Hu Sheng Qian, Holly Clifford, Hong Wang, Xiaomei Zhang, Kristina Gueneva-Boucheva, Todd Bosanac, Diane Wong, Ryan M. Fryer, Jeremy G. Richman, Chris Sarko and Steven S. Pullen

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 712-719; DOI: https://doi.org/10.1124/jpet.115.230706

Gastrointestinal, Hepatic, Pulmonary, and Renal

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ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A₂, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease
Shiho Kanai, Keiichi Ishihara, Eri Kawashita, Toshiyuki Tomoo, Kazuhiro Nagahira, Yasuhiro Hayashi and Satoshi Akiba

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 604-614; DOI: https://doi.org/10.1124/jpet.115.229906

Inflammation, Immunopharmacology, and Asthma

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The Role of Anti-Drug Antibodies in the Pharmacokinetics, Disposition, Target Engagement, and Efficacy of a GITR Agonist Monoclonal Antibody in Mice
Nicholas D. Brunn, Smita Mauze, Danling Gu, Derek Wiswell, Roanna Ueda, Douglas Hodges, Amy M. Beebe, Shuli Zhang and Enrique Escandón

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 574-586; DOI: https://doi.org/10.1124/jpet.115.229864
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Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia
Srinivasan Chandrasekhar, Anita K. Harvey, Xiao-Peng Yu, Mark G. Chambers, Jennifer L. Oskins, Chaohua Lin, Thomas W. Seng, Stefan J. Thibodeaux, Bryan H. Norman, Norman E. Hughes, Matthew A. Schiffler and Matthew J. Fisher

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 635-644; DOI: https://doi.org/10.1124/jpet.115.228932

Neuropharmacology

Open Access
Noncompetitive Inhibition of 5-HT₃ Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling
Gavin E. Jarvis, Roseli Barbosa and Andrew J. Thompson

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 549-562; DOI: https://doi.org/10.1124/jpet.115.230011
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The Phosphodiesterase 10A Selective Inhibitor TAK-063 Improves Cognitive Functions Associated with Schizophrenia in Rodent Models
Eri Shiraishi, Kazunori Suzuki, Akina Harada, Noriko Suzuki and Haruhide Kimura

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 587-595; DOI: https://doi.org/10.1124/jpet.115.230482
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2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations
Weimin C. Hong, Theresa A. Kopajtic, Lifen Xu, Stacey A. Lomenzo, Bernandie Jean, Jeffry D. Madura, Christopher K. Surratt, Mark L. Trudell and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 624-634; DOI: https://doi.org/10.1124/jpet.115.230722
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A Stress-Related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat
Takahiro Shimizu, Shogo Shimizu, Youichirou Higashi, Kumiko Nakamura, Naoki Yoshimura and Motoaki Saito

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 693-701; DOI: https://doi.org/10.1124/jpet.115.230334
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GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia
Kiran Sapkota, Zhihao Mao, Paul Synowicki, Dillon Lieber, Meng Liu, Tsuneya Ikezu, Vivek Gautam and Daniel T. Monaghan

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 702-711; DOI: https://doi.org/10.1124/jpet.115.230391

Toxicology

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Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons
Jie Gao, Sean X. Naughton, Heike Wulff, Vikrant Singh, Wayne D. Beck, Jordi Magrane, Bobby Thomas, Navneet Ammal Kaidery, Caterina M. Hernandez and Alvin V. Terry

Journal of Pharmacology and Experimental Therapeutics March 2016, 356 (3) 645-655; DOI: https://doi.org/10.1124/jpet.115.230839

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Table of Contents

Minireview

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Neuropharmacology

Toxicology

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