Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn

Table of Contents

February 01, 2016; Volume 356,Issue 2

Minireview

  • You have access
    Protoporphyrin IX: the Good, the Bad, and the Ugly
    Madhav Sachar, Karl E. Anderson and Xiaochao Ma
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 267-275; DOI: https://doi.org/10.1124/jpet.115.228130

Behavioral Pharmacology

  • You have access
    Evaluation of the Reinforcing Effect of Quetiapine, Alone and in Combination with Cocaine, in Rhesus Monkeys
    Robert E. Brutcher, Susan H. Nader and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 244-250; DOI: https://doi.org/10.1124/jpet.115.228577

Cardiovascular

  • You have access
    Concomitant Phosphodiesterase 5 Inhibition Enhances Myocardial Protection by Inhaled Nitric Oxide in Ischemia-Reperfusion Injury
    Arpad Lux, Peter Pokreisz, Melissa Swinnen, Ellen Caluwe, Hilde Gillijns, Zsolt Szelid, Bela Merkely and Stefan P. Janssens
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 284-292; DOI: https://doi.org/10.1124/jpet.115.227850
  • You have access
    Histones Differentially Modulate the Anticoagulant and Profibrinolytic Activities of Heparin, Heparin Derivatives, and Dabigatran
    Concetta Tiziana Ammollo, Nicola Semeraro, Maria Rosaria Carratù, Mario Colucci and Fabrizio Semeraro
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 305-313; DOI: https://doi.org/10.1124/jpet.115.229823
  • You have access
    Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin
    Gnanapragasam Arunachalam, Arun Prasath Lakshmanan, Samson Mathews Samuel, Chris R. Triggle and Hong Ding
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 314-323; DOI: https://doi.org/10.1124/jpet.115.226894
  • You have access
    Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction
    Stevan P. Tofovic, Eman M. Salah, Glenn J. Smits, Eric T. Whalley, Barry Ticho, Aaron Deykin and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 333-340; DOI: https://doi.org/10.1124/jpet.115.228841
  • You have access
    Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide
    Toshihiro Sakurai, Akiko Sakurai, Boris L. Vaisman, Marcelo J. Amar, Chengyu Liu, Scott M. Gordon, Steven K. Drake, Milton Pryor, Maureen L. Sampson, Ling Yang, Lita A. Freeman and Alan T. Remaley
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 341-353; DOI: https://doi.org/10.1124/jpet.115.229740
  • You have access
    Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats
    Samar Rezq and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 456-465; DOI: https://doi.org/10.1124/jpet.115.229146
  • <em>β</em> Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves <em>β</em><sub>2</sub>-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia
    You have access
    β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia
    Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Giuseppina Gambino, Maria Loreta D’Amico, Franco Rengo, Walter J Koch, Dario Leosco, Nicola Ferrara and Giuseppe Rengo
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 503-513; DOI: https://doi.org/10.1124/jpet.115.228411
  • Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice: A Comparison with Nicotinic Acid
    You have access
    Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice: A Comparison with Nicotinic Acid
    Lukasz Mateuszuk, Agnieszka Jasztal, Edyta Maslak, Marlena Gasior-Glogowska, Malgorzata Baranska, Barbara Sitek, Renata Kostogrys, Agnieszka Zakrzewska, Agnieszka Kij, Maria Walczak and Stefan Chlopicki
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 514-524; DOI: https://doi.org/10.1124/jpet.115.228643

Cellular and Molecular

  • You have access
    Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma
    Hilary Nicholson, Christophe Mesangeau, Christopher R. McCurdy and Wayne D. Bowen
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 232-243; DOI: https://doi.org/10.1124/jpet.115.228387
  • You have access
    Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function
    Daniel Heller, Jamie R. Doyle, Venkata S. Raman, Martin Beinborn, Krishna Kumar and Alan S. Kopin
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 276-283; DOI: https://doi.org/10.1124/jpet.115.227058
  • You have access
    Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines
    Esther P. Jane, Daniel R. Premkumar, Jonathon M. Cavaleri, Philip A. Sutera, Thatchana Rajasekar and Ian F. Pollack
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 354-365; DOI: https://doi.org/10.1124/jpet.115.230052
  • You have access
    Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor–Mediated Signaling in Neuroblastoma
    Mehrnoosh Soori, Guizhen Lu and Robert W. Mason
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 375-386; DOI: https://doi.org/10.1124/jpet.115.229229
  • You have access
    Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK
    Qi Wang, Stephen P. Amato, David M. Rubitski, Matthew M. Hayward, Bethany L. Kormos, Patrick R. Verhoest, Lan Xu, Nicholas J. Brandon and Michael D. Ehlers
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 410-423; DOI: https://doi.org/10.1124/jpet.115.229880

Chemotherapy, Antibiotics, and Gene Therapy

  • Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase II<em>α</em> Isoform
    You have access
    Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform
    Brian B. Hasinoff, Xing Wu, Daywin Patel, Ragu Kanagasabai, Soumendrakrishna Karmahapatra and Jack C. Yalowich
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 397-409; DOI: https://doi.org/10.1124/jpet.115.228650

Drug Discovery and Translational Medicine

  • You have access
    Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors
    Andrew Alt, Annapurna Pendri, Robert L. Bertekap, Guo Li, Yulia Benitex, Michelle Nophsker, Kristin L. Rockwell, Neil T. Burford, Chi Shing Sum, Jing Chen, John J. Herbst, Meredith Ferrante, Adam Hendricson, Mary Ellen Cvijic, Ryan S. Westphal, Jonathan O’Connell, Martyn Banks, Litao Zhang, Robert G. Gentles, Susan Jenkins, James Loy and John E. Macor
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 293-304; DOI: https://doi.org/10.1124/jpet.115.226910
  • You have access
    Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis
    Rink-Jan Lohman, Abishek Iyer, Thomas J. Fairlie, Adam Cotterell, Praveer Gupta, Robert C. Reid, David A. Vesey, Matthew J. Sweet and David P. Fairlie
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 387-396; DOI: https://doi.org/10.1124/jpet.115.229328
  • You have access
    A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder
    Michael A. Statnick, Yanyun Chen, Michael Ansonoff, Jeffrey M. Witkin, Linda Rorick-Kehn, Todd M. Suter, Min Song, Charlie Hu, Celia Lafuente, Alma Jiménez, Ana Benito, Nuria Diaz, Maria Angeles Martínez-Grau, Miguel A. Toledo and John E. Pintar
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 493-502; DOI: https://doi.org/10.1124/jpet.115.228221

Endocrine and Diabetes

  • You have access
    Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K/Akt/mTOR Signaling Pathway and Benefits Wound Healing in Genetically Diabetic Mice
    Eryun Zhang, Bo Gao, Li Yang, Xiaojun Wu and Zhengtao Wang
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 324-332; DOI: https://doi.org/10.1124/jpet.115.229369
  • You have access
    A Novel Allosteric Insulin Receptor–Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys
    Padma Bezwada, Jingsong Zhao, Ken Der, Bob Shimizu, Liching Cao, Ago Ahene, Paul Rubin and Kirk Johnson
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 466-473; DOI: https://doi.org/10.1124/jpet.115.229690
  • Peripheral Adenosine A<sub>3</sub> Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H<sub>1</sub> Receptors
    You have access
    Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors
    Jesse Lea Carlin, Dilip K. Tosh, Cuiying Xiao, Ramón A. Piñol, Zhoumou Chen, Daniela Salvemini, Oksana Gavrilova, Kenneth A. Jacobson and Marc L. Reitman
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 474-482; DOI: https://doi.org/10.1124/jpet.115.229872

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Enteric Dysfunctions in Experimental Parkinson’s Disease: Alterations of Excitatory Cholinergic Neurotransmission Regulating Colonic Motility in Rats
    You have access
    Enteric Dysfunctions in Experimental Parkinson’s Disease: Alterations of Excitatory Cholinergic Neurotransmission Regulating Colonic Motility in Rats
    Matteo Fornai, Carolina Pellegrini, Luca Antonioli, Cristina Segnani, Chiara Ippolito, Elisabetta Barocelli, Vigilio Ballabeni, Gaia Vegezzi, Zainab Al Harraq, Fabio Blandini, Giovanna Levandis, Silvia Cerri, Corrado Blandizzi, Nunzia Bernardini and Rocchina Colucci
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 434-444; DOI: https://doi.org/10.1124/jpet.115.228510

Metabolism, Transport, and Pharmacogenomics

  • You have access
    Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases
    Shruthi Vaidhyanathan, Brynna Wilken-Resman, Daniel J. Ma, Karen E. Parrish, Rajendar K. Mittapalli, Brett L. Carlson, Jann N. Sarkaria and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 251-259; DOI: https://doi.org/10.1124/jpet.115.229393
  • Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4
    You have access
    Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4
    Atsushi Kawase, Taiki Yamamoto, Sachiko Egashira and Masahiro Iwaki
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 366-374; DOI: https://doi.org/10.1124/jpet.115.229104

Neuropharmacology

  • You have access
    Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050
    Mika Naganawa, Gemma L. Dickinson, Ming-Qiang Zheng, Shannan Henry, Francois Vandenhende, Jennifer Witcher, Robert Bell, Nabeel Nabulsi, Shu-Fei Lin, Jim Ropchan, Alexander Neumeister, Mohini Ranganathan, Johannes Tauscher, Yiyun Huang and Richard E. Carson
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 260-266; DOI: https://doi.org/10.1124/jpet.115.229278
  • You have access
    Tonically Active cAMP-Dependent Signaling in the Ventrolateral Medulla Regulates Sympathetic and Cardiac Vagal Outflows
    Vikram J. Tallapragada, Cara M. Hildreth, Peter G.R. Burke, Darryl A. Raley, Sarah F. Hassan, Simon McMullan and Ann K. Goodchild
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 424-433; DOI: https://doi.org/10.1124/jpet.115.227488
  • You have access
    Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus
    Kentaro Takeda, Yoshimasa Yamaguchi, Masataka Hino and Fusao Kato
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 445-455; DOI: https://doi.org/10.1124/jpet.115.229021
  • Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells
    You have access
    Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells
    David S. Goldstein, Yunden Jinsmaa, Patti Sullivan, Courtney Holmes, Irwin J. Kopin and Yehonatan Sharabi
    Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 483-492; DOI: https://doi.org/10.1124/jpet.115.230201
Back to top
PreviousNext

In this issue

Journal of Pharmacology and Experimental Therapeutics: 356 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 356, Issue 2
1 Feb 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Minireview
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Most Read
Loading
  • Potential Clinical Uses of CBG
  • Ocular Drug Delivery: Past, Present, and Future
  • Rho GTPase–Pathway Inhibitor Reduces Markers of Fibrosis
  • Nose-to-Brain Delivery
  • SEP-363856, a Novel, Non-D2 Psychotropic Agent
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics