Journal of Pharmacology and Experimental Therapeutics: 356 (2)

February 01, 2016; Volume 356,Issue 2

Minireview

You have access
Protoporphyrin IX: the Good, the Bad, and the Ugly
Madhav Sachar, Karl E. Anderson and Xiaochao Ma

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 267-275; DOI: https://doi.org/10.1124/jpet.115.228130

Behavioral Pharmacology

You have access
Evaluation of the Reinforcing Effect of Quetiapine, Alone and in Combination with Cocaine, in Rhesus Monkeys
Robert E. Brutcher, Susan H. Nader and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 244-250; DOI: https://doi.org/10.1124/jpet.115.228577

Cardiovascular

You have access
Concomitant Phosphodiesterase 5 Inhibition Enhances Myocardial Protection by Inhaled Nitric Oxide in Ischemia-Reperfusion Injury
Arpad Lux, Peter Pokreisz, Melissa Swinnen, Ellen Caluwe, Hilde Gillijns, Zsolt Szelid, Bela Merkely and Stefan P. Janssens

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 284-292; DOI: https://doi.org/10.1124/jpet.115.227850
You have access
Histones Differentially Modulate the Anticoagulant and Profibrinolytic Activities of Heparin, Heparin Derivatives, and Dabigatran
Concetta Tiziana Ammollo, Nicola Semeraro, Maria Rosaria Carratù, Mario Colucci and Fabrizio Semeraro

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 305-313; DOI: https://doi.org/10.1124/jpet.115.229823
You have access
Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin
Gnanapragasam Arunachalam, Arun Prasath Lakshmanan, Samson Mathews Samuel, Chris R. Triggle and Hong Ding

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 314-323; DOI: https://doi.org/10.1124/jpet.115.226894
You have access
Dual A₁/A_2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction
Stevan P. Tofovic, Eman M. Salah, Glenn J. Smits, Eric T. Whalley, Barry Ticho, Aaron Deykin and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 333-340; DOI: https://doi.org/10.1124/jpet.115.228841
You have access
Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide
Toshihiro Sakurai, Akiko Sakurai, Boris L. Vaisman, Marcelo J. Amar, Chengyu Liu, Scott M. Gordon, Steven K. Drake, Milton Pryor, Maureen L. Sampson, Ling Yang, Lita A. Freeman and Alan T. Remaley

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 341-353; DOI: https://doi.org/10.1124/jpet.115.229740
You have access
Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats
Samar Rezq and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 456-465; DOI: https://doi.org/10.1124/jpet.115.229146
You have access
β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β₂-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia
Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Giuseppina Gambino, Maria Loreta D’Amico, Franco Rengo, Walter J Koch, Dario Leosco, Nicola Ferrara and Giuseppe Rengo

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 503-513; DOI: https://doi.org/10.1124/jpet.115.228411
You have access
Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice: A Comparison with Nicotinic Acid
Lukasz Mateuszuk, Agnieszka Jasztal, Edyta Maslak, Marlena Gasior-Glogowska, Malgorzata Baranska, Barbara Sitek, Renata Kostogrys, Agnieszka Zakrzewska, Agnieszka Kij, Maria Walczak and Stefan Chlopicki

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 514-524; DOI: https://doi.org/10.1124/jpet.115.228643

Cellular and Molecular

You have access
Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma
Hilary Nicholson, Christophe Mesangeau, Christopher R. McCurdy and Wayne D. Bowen

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 232-243; DOI: https://doi.org/10.1124/jpet.115.228387
You have access
Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function
Daniel Heller, Jamie R. Doyle, Venkata S. Raman, Martin Beinborn, Krishna Kumar and Alan S. Kopin

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 276-283; DOI: https://doi.org/10.1124/jpet.115.227058
You have access
Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737–Mediated Cell Death in Malignant Human Glioma Cell Lines
Esther P. Jane, Daniel R. Premkumar, Jonathon M. Cavaleri, Philip A. Sutera, Thatchana Rajasekar and Ian F. Pollack

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 354-365; DOI: https://doi.org/10.1124/jpet.115.230052
You have access
Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor–Mediated Signaling in Neuroblastoma
Mehrnoosh Soori, Guizhen Lu and Robert W. Mason

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 375-386; DOI: https://doi.org/10.1124/jpet.115.229229
You have access
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK
Qi Wang, Stephen P. Amato, David M. Rubitski, Matthew M. Hayward, Bethany L. Kormos, Patrick R. Verhoest, Lan Xu, Nicholas J. Brandon and Michael D. Ehlers

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 410-423; DOI: https://doi.org/10.1124/jpet.115.229880

Chemotherapy, Antibiotics, and Gene Therapy

You have access
Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform
Brian B. Hasinoff, Xing Wu, Daywin Patel, Ragu Kanagasabai, Soumendrakrishna Karmahapatra and Jack C. Yalowich

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 397-409; DOI: https://doi.org/10.1124/jpet.115.228650

Drug Discovery and Translational Medicine

You have access
Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M₁ Muscarinic Receptors
Andrew Alt, Annapurna Pendri, Robert L. Bertekap, Guo Li, Yulia Benitex, Michelle Nophsker, Kristin L. Rockwell, Neil T. Burford, Chi Shing Sum, Jing Chen, John J. Herbst, Meredith Ferrante, Adam Hendricson, Mary Ellen Cvijic, Ryan S. Westphal, Jonathan O’Connell, Martyn Banks, Litao Zhang, Robert G. Gentles, Susan Jenkins, James Loy and John E. Macor

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 293-304; DOI: https://doi.org/10.1124/jpet.115.226910
You have access
Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis
Rink-Jan Lohman, Abishek Iyer, Thomas J. Fairlie, Adam Cotterell, Praveer Gupta, Robert C. Reid, David A. Vesey, Matthew J. Sweet and David P. Fairlie

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 387-396; DOI: https://doi.org/10.1124/jpet.115.229328
You have access
A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder
Michael A. Statnick, Yanyun Chen, Michael Ansonoff, Jeffrey M. Witkin, Linda Rorick-Kehn, Todd M. Suter, Min Song, Charlie Hu, Celia Lafuente, Alma Jiménez, Ana Benito, Nuria Diaz, Maria Angeles Martínez-Grau, Miguel A. Toledo and John E. Pintar

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 493-502; DOI: https://doi.org/10.1124/jpet.115.228221

Endocrine and Diabetes

You have access
Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K/Akt/mTOR Signaling Pathway and Benefits Wound Healing in Genetically Diabetic Mice
Eryun Zhang, Bo Gao, Li Yang, Xiaojun Wu and Zhengtao Wang

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 324-332; DOI: https://doi.org/10.1124/jpet.115.229369
You have access
A Novel Allosteric Insulin Receptor–Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys
Padma Bezwada, Jingsong Zhao, Ken Der, Bob Shimizu, Liching Cao, Ago Ahene, Paul Rubin and Kirk Johnson

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 466-473; DOI: https://doi.org/10.1124/jpet.115.229690
You have access
Peripheral Adenosine A₃ Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H₁ Receptors
Jesse Lea Carlin, Dilip K. Tosh, Cuiying Xiao, Ramón A. Piñol, Zhoumou Chen, Daniela Salvemini, Oksana Gavrilova, Kenneth A. Jacobson and Marc L. Reitman

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 474-482; DOI: https://doi.org/10.1124/jpet.115.229872

Gastrointestinal, Hepatic, Pulmonary, and Renal

You have access
Enteric Dysfunctions in Experimental Parkinson’s Disease: Alterations of Excitatory Cholinergic Neurotransmission Regulating Colonic Motility in Rats
Matteo Fornai, Carolina Pellegrini, Luca Antonioli, Cristina Segnani, Chiara Ippolito, Elisabetta Barocelli, Vigilio Ballabeni, Gaia Vegezzi, Zainab Al Harraq, Fabio Blandini, Giovanna Levandis, Silvia Cerri, Corrado Blandizzi, Nunzia Bernardini and Rocchina Colucci

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 434-444; DOI: https://doi.org/10.1124/jpet.115.228510

Metabolism, Transport, and Pharmacogenomics

You have access
Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases
Shruthi Vaidhyanathan, Brynna Wilken-Resman, Daniel J. Ma, Karen E. Parrish, Rajendar K. Mittapalli, Brett L. Carlson, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 251-259; DOI: https://doi.org/10.1124/jpet.115.229393
You have access
Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4
Atsushi Kawase, Taiki Yamamoto, Sachiko Egashira and Masahiro Iwaki

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 366-374; DOI: https://doi.org/10.1124/jpet.115.229104

Neuropharmacology

You have access
Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer ¹¹C-LY2795050
Mika Naganawa, Gemma L. Dickinson, Ming-Qiang Zheng, Shannan Henry, Francois Vandenhende, Jennifer Witcher, Robert Bell, Nabeel Nabulsi, Shu-Fei Lin, Jim Ropchan, Alexander Neumeister, Mohini Ranganathan, Johannes Tauscher, Yiyun Huang and Richard E. Carson

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 260-266; DOI: https://doi.org/10.1124/jpet.115.229278
You have access
Tonically Active cAMP-Dependent Signaling in the Ventrolateral Medulla Regulates Sympathetic and Cardiac Vagal Outflows
Vikram J. Tallapragada, Cara M. Hildreth, Peter G.R. Burke, Darryl A. Raley, Sarah F. Hassan, Simon McMullan and Ann K. Goodchild

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 424-433; DOI: https://doi.org/10.1124/jpet.115.227488
You have access
Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus
Kentaro Takeda, Yoshimasa Yamaguchi, Masataka Hino and Fusao Kato

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 445-455; DOI: https://doi.org/10.1124/jpet.115.229021
You have access
Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells
David S. Goldstein, Yunden Jinsmaa, Patti Sullivan, Courtney Holmes, Irwin J. Kopin and Yehonatan Sharabi

Journal of Pharmacology and Experimental Therapeutics February 2016, 356 (2) 483-492; DOI: https://doi.org/10.1124/jpet.115.230201

Main menu

User menu

Search

Table of Contents

Minireview

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals