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Research ArticleDrug Discovery and Translational Medicine

Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor

Licheng Shi, Sonya G. Lehto, Dawn X. D. Zhu, Hong Sun, Jianhua Zhang, Brian P. Smith, David C. Immke, Kenneth D. Wild and Cen Xu
Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 223-231; DOI: https://doi.org/10.1124/jpet.115.227793
Licheng Shi
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Sonya G. Lehto
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Dawn X. D. Zhu
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Hong Sun
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Jianhua Zhang
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Brian P. Smith
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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David C. Immke
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Kenneth D. Wild
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Cen Xu
Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
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Article Information

vol. 356 no. 1 223-231
DOI 
https://doi.org/10.1124/jpet.115.227793
PubMed 
26559125

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 16, 2015
  • Accepted November 10, 2015
  • Published online December 15, 2015.

Article Versions

  • Earlier version (November 11, 2015 - 09:55).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Licheng Shi1,
  2. Sonya G. Lehto1,
  3. Dawn X. D. Zhu,
  4. Hong Sun,
  5. Jianhua Zhang,
  6. Brian P. Smith,
  7. David C. Immke,
  8. Kenneth D. Wild, and
  9. Cen Xu
  1. Department of Neuroscience (L.S., S.G.L., D.X.D.Z., H.S., J.Z., D.C.I., K.D.W., C.X.), Department of Global Biostatistical Science (B.P.S.), Amgen Inc., Thousand Oaks, California
  1. Address correspondence to:
    Cen Xu, One Amgen Center Dr. MS 29-2-B, Thousand Oaks, CA 91320-1799. E-mail: cenx{at}amgen.com
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Journal of Pharmacology and Experimental Therapeutics: 356 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 356, Issue 1
1 Jan 2016
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Research ArticleDrug Discovery and Translational Medicine

Pharmacologic Characterization of AMG 334

Licheng Shi, Sonya G. Lehto, Dawn X. D. Zhu, Hong Sun, Jianhua Zhang, Brian P. Smith, David C. Immke, Kenneth D. Wild and Cen Xu
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 223-231; DOI: https://doi.org/10.1124/jpet.115.227793

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Research ArticleDrug Discovery and Translational Medicine

Pharmacologic Characterization of AMG 334

Licheng Shi, Sonya G. Lehto, Dawn X. D. Zhu, Hong Sun, Jianhua Zhang, Brian P. Smith, David C. Immke, Kenneth D. Wild and Cen Xu
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 223-231; DOI: https://doi.org/10.1124/jpet.115.227793
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