Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleBehavioral Pharmacology

Chronic Δ9-Tetrahydrocannabinol during Adolescence Differentially Modulates Striatal CB1 Receptor Expression and the Acute and Chronic Effects on Learning in Adult Rats

Peter F. Weed, Catalin M. Filipeanu, Myles J. Ketchum and Peter J. Winsauer
Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 20-31; DOI: https://doi.org/10.1124/jpet.115.227181
Peter F. Weed
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (P.F.W., M.J.K., P.J.W.), Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (P.F.W.), and Department of Pharmacology, Howard University, Washington, D.C. (C.M.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Catalin M. Filipeanu
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (P.F.W., M.J.K., P.J.W.), Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (P.F.W.), and Department of Pharmacology, Howard University, Washington, D.C. (C.M.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Myles J. Ketchum
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (P.F.W., M.J.K., P.J.W.), Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (P.F.W.), and Department of Pharmacology, Howard University, Washington, D.C. (C.M.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter J. Winsauer
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana (P.F.W., M.J.K., P.J.W.), Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (P.F.W.), and Department of Pharmacology, Howard University, Washington, D.C. (C.M.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The purpose of this study was to determine whether chronic administration of Δ9-tetrahydrocannabinol (THC) during adolescence would (1) modify any sex-specific effects of THC on learning and (2) affect the development of tolerance to THC as an adult. Male and female rats received daily injections of saline or 5.6 mg/kg of THC from postnatal day 35–75, yielding four groups (female/saline, female/THC, male/saline, and male/THC). Rats were then trained on a procedure that assayed both learning and performance behavior and administered 0.32–18 mg/kg of THC acutely as adults (experiment 1). THC produced rate-decreasing and error-increasing effects in both sexes; however, female rats were more sensitive than male rats were to the rate-decreasing effects. Rats were then chronically administered 10 mg/kg of THC (experiment 2). Rats that received THC during adolescence developed tolerance to the rate-decreasing effects more slowly and less completely than did rats that received saline; in addition, females developed tolerance to the error-increasing effects of THC slower than males did. Western blot analysis of brain tissue indicated long-term changes in hippocampal and striatal cannabinoid type-1 receptor (CB1R) levels despite levels that were indistinguishable immediately after chronic treatment during adolescence. Striatal CB1R levels were increased in adult rats that received THC during adolescence; hippocampal CB1R levels varied by sex. In summary, female rats were more sensitive than male rats were to the acute and chronic effects of THC, and chronic administration of THC during adolescence produced long-term changes in CB1R levels that correlated with decreased tolerance development to the rate-decreasing effects of THC.

Footnotes

    • Received June 24, 2015.
    • Accepted October 9, 2015.
  • These data were adapted from the dissertation of Peter F. Weed: Effects of Chronic Δ9-Tetrahydrocannabinol during Adolescence on Adult Repeated Acquisition and Performance Behavior, Tolerance, and CB1 Receptor Expression in Male and Female Rats. In addition, some of these data were previously presented as a poster at the poster presentation: Weed PF (2015) ASPET meeting in Boston, MA, entitled, “Effects of Chronic D9-tetrahydrocannabinol during Adolescence on Adult Repeated Acquisition and Performance Behavior and CB1 Receptor ExpresQ: 2 sion in Male and Female Rats.” 2015 ASPET Conference; Mar 28-Apr 1; Boston, MA. abstract 101699, American Society of Pharmacology and Experimental Therapeutics, Bethesda.

  • dx.doi.org/10.1124/jpet.115.227181.

  • Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 356 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 356, Issue 1
1 Jan 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Chronic Δ9-Tetrahydrocannabinol during Adolescence Differentially Modulates Striatal CB1 Receptor Expression and the Acute and Chronic Effects on Learning in Adult Rats
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleBehavioral Pharmacology

Tolerance Development to THC

Peter F. Weed, Catalin M. Filipeanu, Myles J. Ketchum and Peter J. Winsauer
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 20-31; DOI: https://doi.org/10.1124/jpet.115.227181

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleBehavioral Pharmacology

Tolerance Development to THC

Peter F. Weed, Catalin M. Filipeanu, Myles J. Ketchum and Peter J. Winsauer
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 20-31; DOI: https://doi.org/10.1124/jpet.115.227181
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Cromakalim prodrugs are analgesics in chronic pain models
  • Role of Residues S426 and S430 in Cannabinoid Tolerance
  • Running Title: Stimulus effects of nicotine aerosol
Show more Behavioral Pharmacology

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics