Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleMinireview

Adverse Outcome Pathways—Organizing Toxicological Information to Improve Decision Making

Stephen W. Edwards, Yu-Mei Tan, Daniel L. Villeneuve, M.E. Meek and Charlene A. McQueen
Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 170-181; DOI: https://doi.org/10.1124/jpet.115.228239
Stephen W. Edwards
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yu-Mei Tan
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel L. Villeneuve
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.E. Meek
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charlene A. McQueen
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading
Submit a Response to This Article
Compose eLetter

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 356 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 356, Issue 1
1 Jan 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Adverse Outcome Pathways—Organizing Toxicological Information to Improve Decision Making
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleMinireview

Adverse Outcome Pathways

Stephen W. Edwards, Yu-Mei Tan, Daniel L. Villeneuve, M.E. Meek and Charlene A. McQueen
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 170-181; DOI: https://doi.org/10.1124/jpet.115.228239

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleMinireview

Adverse Outcome Pathways

Stephen W. Edwards, Yu-Mei Tan, Daniel L. Villeneuve, M.E. Meek and Charlene A. McQueen
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 170-181; DOI: https://doi.org/10.1124/jpet.115.228239
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Adverse Outcome Pathways—Evolution of the Concept
    • Adverse Outcome Pathways—Where Are We Now?
    • Developing a MOA from an AOP and Absorption, Distribution, Metabolism, and Excretion (ADME) Information
    • Applications for the AOP/MOA Framework
    • Conclusions and Future Directions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Potential Clinical Uses of CBG
  • Phytochemicals treat IBD and colon cancer
  • Biomarker-Centric Approach to Drug Development
Show more Minireview

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics