Research ArticleMinireview
Adverse Outcome Pathways—Organizing Toxicological Information to Improve Decision Making
Stephen W. Edwards, Yu-Mei Tan, Daniel L. Villeneuve, M.E. Meek and Charlene A. McQueen
Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 170-181; DOI: https://doi.org/10.1124/jpet.115.228239
Stephen W. Edwards
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
Yu-Mei Tan
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
Daniel L. Villeneuve
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
M.E. Meek
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)
Charlene A. McQueen
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.)

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Research ArticleMinireview
Adverse Outcome Pathways
Stephen W. Edwards, Yu-Mei Tan, Daniel L. Villeneuve, M.E. Meek and Charlene A. McQueen
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 170-181; DOI: https://doi.org/10.1124/jpet.115.228239
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- Article
- Abstract
- Introduction
- Adverse Outcome Pathways—Evolution of the Concept
- Adverse Outcome Pathways—Where Are We Now?
- Developing a MOA from an AOP and Absorption, Distribution, Metabolism, and Excretion (ADME) Information
- Applications for the AOP/MOA Framework
- Conclusions and Future Directions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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