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Research ArticleInflammation, Immunopharmacology, and Asthma

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang
Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860
Qilu Fang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Liancheng Deng
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Lintao Wang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Yali Zhang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Qiaoyou Weng
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Haimin Yin
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Yong Pan
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Chao Tong
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Jingying Wang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Guang Liang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Article Information

vol. 355 no. 2 235-246
DOI 
https://doi.org/10.1124/jpet.115.226860
PubMed 
26354992

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received June 17, 2015
  • Accepted September 8, 2015
  • Published online October 8, 2015.

Article Versions

  • Earlier version (September 9, 2015 - 11:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qilu Fang,
  2. Liancheng Deng,
  3. Lintao Wang,
  4. Yali Zhang,
  5. Qiaoyou Weng,
  6. Haimin Yin,
  7. Yong Pan,
  8. Chao Tong,
  9. Jingying Wang, and
  10. Guang Liang
  1. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
  1. Address correspondence to:
    Dr. Guang Liang, Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. E-mail: wzmcliangguang{at}163.com
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Journal of Pharmacology and Experimental Therapeutics: 355 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 355, Issue 2
1 Nov 2015
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Research ArticleInflammation, Immunopharmacology, and Asthma

Chalcone Prevents ORG via Anti-Inflammatory Action

Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang
Journal of Pharmacology and Experimental Therapeutics November 1, 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860

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Research ArticleInflammation, Immunopharmacology, and Asthma

Chalcone Prevents ORG via Anti-Inflammatory Action

Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang
Journal of Pharmacology and Experimental Therapeutics November 1, 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860
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