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Research ArticleInflammation, Immunopharmacology, and Asthma

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang
Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860
Qilu Fang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Liancheng Deng
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Lintao Wang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Yali Zhang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Qiaoyou Weng
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Haimin Yin
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Yong Pan
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Chao Tong
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Jingying Wang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Guang Liang
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China (Q.F., L.D., L.W., Y.Z., Q.W., H.Y.,Y.P.,C.T., J.W., G.L.); Department of Pharmacy, Affiliated Sixth Hospital, Wenzhou Medical University, Lishui, Zhejiang, China (L.D.); and Diabetes Center and Department of Endocrinology, Affiliated Second Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (H.Y.)
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Abstract

The prevalence of obesity has increased dramatically worldwide leading to increases in obesity-related complications, such as obesity-related glomerulopathy (ORG). Obesity is a state of chronic, low-grade inflammation, and increased inflammation in the adipose and kidney tissues has been shown to promote the progression of renal damage in obesity. Current therapeutic options for ORG are fairly limited and, as a result, we are seeing increased rates of progression to end-stage renal disease. Chalcones are a class of naturally occurring compounds with various pharmacological properties. 1-(3,4-Dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one (L2H17) is a chalcone that we have previously synthesized and found capable of inhibiting the lipopolysaccharide-induced inflammatory response in macrophages. In this study, we investigated L2H17’s effect on obesity-induced renal injury using palmitic acid–induced mouse peritoneal macrophages and high fat diet–fed mice. Our results indicate that L2H17 protects against renal injury through the inhibition of the mitogen-activated protein kinase/nuclear factor κB pathways significantly by decreasing the expression of proinflammatory cytokines and cell adhesion molecules and improving kidney histology and pathology. These findings lead us to believe that L2H17, as an anti-inflammatory agent, can be a potential therapeutic option in treating ORG.

Footnotes

    • Received June 17, 2015.
    • Accepted September 8, 2015.
  • Q.F. and L.D. contributed equally to this work.

  • This study was supported by the Natural Science Foundation of China [Grants 81300678, 81200572, 81302821, and 81371028], Zhejiang Provincial Natural Science Funding [Grants LQ14H310003 and LQ13H310002], and High-Level Innovative Talent Funding from the Zhejiang Department of Health [Grant 2010-017].

  • dx.doi.org/10.1124/jpet.115.226860.

  • Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 355 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 355, Issue 2
1 Nov 2015
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Research ArticleInflammation, Immunopharmacology, and Asthma

Chalcone Prevents ORG via Anti-Inflammatory Action

Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang
Journal of Pharmacology and Experimental Therapeutics November 1, 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860

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Research ArticleInflammation, Immunopharmacology, and Asthma

Chalcone Prevents ORG via Anti-Inflammatory Action

Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang
Journal of Pharmacology and Experimental Therapeutics November 1, 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860
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