Journal of Pharmacology and Experimental Therapeutics: 355 (2)

November 01, 2015; Volume 355,Issue 2

Highlighted Papers

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Effects of Nicotinic Drugs on Pain-Depressed Behavior
Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 136; DOI: https://doi.org/10.1124/jpet.115.1115HI
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Selective SOAT2 Inhibitors Improve Hypercholesterolemia and Atherosclerosis
Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 136; DOI: https://doi.org/10.1124/jpet.115.1115HIa
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Antisense Targeting of DMPK for Treatment of Myotonic Dystrophy Type 1
Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 136; DOI: https://doi.org/10.1124/jpet.115.1115HIb
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Factor D Inhibition by Lampalizumab for the Treatment of Geographic Atrophy
Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 136; DOI: https://doi.org/10.1124/jpet.115.1115HIc

Minireviews

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Combretastatins: More Than Just Vascular Targeting Agents?
Lisa M. Greene, Mary J. Meegan and Daniela M. Zisterer

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 212-227; DOI: https://doi.org/10.1124/jpet.115.226225
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Fibromyalgia Syndrome in Need of Effective Treatments
Theoharis C. Theoharides, Irene Tsilioni, Lauren Arbetman, Smaro Panagiotidou, Julia M. Stewart, Rae M. Gleason and Irwin J. Russell

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 255-263; DOI: https://doi.org/10.1124/jpet.115.227298

Behavioral Pharmacology

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Effects of Nicotinic Acetylcholine Receptor Agonists in Assays of Acute Pain-Stimulated and Pain-Depressed Behaviors in Rats
Kelen C. Freitas, F. Ivy Carroll and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 341-350; DOI: https://doi.org/10.1124/jpet.115.226803

Cellular and Molecular

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Functional Selectivity of Kappa Opioid Receptor Agonists in Peripheral Sensory Neurons
Raehannah J. Jamshidi, Blaine A. Jacobs, Laura C. Sullivan, Teresa A. Chavera, Rachel M. Saylor, Thomas E. Prisinzano, William P. Clarke and Kelly A. Berg

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 174-182; DOI: https://doi.org/10.1124/jpet.115.225896
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Recruitment of β-Arrestin 1 and 2 to the β₂-Adrenoceptor: Analysis of 65 Ligands
Timo Littmann, Martin Göttle, Michael T. Reinartz, Solveig Kälble, Irving W. Wainer, Takeaki Ozawa and Roland Seifert

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 183-190; DOI: https://doi.org/10.1124/jpet.115.227959
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Electrophysiological Characterization of Human and Mouse Sodium-Dependent Citrate Transporters (NaCT/SLC13A5) Reveal Species Differences with Respect to Substrate Sensitivity and Cation Dependence
Ruud Zwart, Polina M. Peeva, James X. Rong and Emanuele Sher

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 247-254; DOI: https://doi.org/10.1124/jpet.115.226902
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2,5-Dimethyl-Celecoxib Inhibits Cell Cycle Progression and Induces Apoptosis in Human Leukemia Cells
Cyril Sobolewski, Jiyun Rhim, Noémie Legrand, Florian Muller, Claudia Cerella, Fabienne Mack, Sébastien Chateauvieux, Jeoung-Gyun Kim, Ah-Young Yoon, Kyu-Won Kim, Mario Dicato and Marc Diederich

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 308-328; DOI: https://doi.org/10.1124/jpet.115.225011

Chemotherapy, Antibiotics, and Gene Therapy

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Induction of Epithelial-Mesenchymal Transition via Activation of Epidermal Growth Factor Receptor Contributes to Sunitinib Resistance in Human Renal Cell Carcinoma Cell Lines
Atsushi Mizumoto, Kazuhiro Yamamoto, Yuko Nakayama, Kohji Takara, Tsutomu Nakagawa, Takeshi Hirano and Midori Hirai

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 152-158; DOI: https://doi.org/10.1124/jpet.115.226639
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Polymer Micelle Formulations of Proteasome Inhibitor Carfilzomib for Improved Metabolic Stability and Anticancer Efficacy in Human Multiple Myeloma and Lung Cancer Cell Lines
Lin Ao, Derek Reichel, Di Hu, Hyunyoung Jeong, Kyung Bo Kim, Younsoo Bae and Wooin Lee

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 168-173; DOI: https://doi.org/10.1124/jpet.115.226993

Drug Discovery and Translational Medicine

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Temporal Pharmacokinetic/Pharmacodynamic Interaction between Human CD3ε Antigen–Targeted Monoclonal Antibody Otelixizumab and CD3ε Binding and Expression in Human Peripheral Blood Mononuclear Cell Static Culture
Kevin R. Page, Enrica Mezzalana, Alexander J. MacDonald, Stefano Zamuner, Giuseppe De Nicolao and Andre van Maurik

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 199-205; DOI: https://doi.org/10.1124/jpet.115.224899
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A Mechanistic Pharmacokinetic/Pharmacodynamic Model of Factor D Inhibition in Cynomolgus Monkeys by Lampalizumab for the Treatment of Geographic Atrophy
Kha N. Le, Leonid Gibiansky, Jeremy Good, Teresa Davancaze, Menno van Lookeren Campagne, Kelly M. Loyet, Alyssa Morimoto, Jin Jin, Lisa A. Damico-Beyer and William D. Hanley

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 288-296; DOI: https://doi.org/10.1124/jpet.115.227223
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New Pyripyropene A Derivatives, Highly SOAT2-Selective Inhibitors, Improve Hypercholesterolemia and Atherosclerosis in Atherogenic Mouse Models
Taichi Ohshiro, Masaki Ohtawa, Tohru Nagamitsu, Daisuke Matsuda, Hiroaki Yagyu, Matthew A. Davis, Lawrence L. Rudel, Shun Ishibashi and Hiroshi Tomoda

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 297-307; DOI: https://doi.org/10.1124/jpet.115.227348
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Identification and Characterization of Modified Antisense Oligonucleotides Targeting DMPK in Mice and Nonhuman Primates for the Treatment of Myotonic Dystrophy Type 1
Sanjay K. Pandey, Thurman M. Wheeler, Samantha L. Justice, Aneeza Kim, Husam S. Younis, Danielle Gattis, Dominic Jauvin, Jack Puymirat, Eric E. Swayze, Susan M. Freier, C. Frank Bennett, Charles A. Thornton and A. Robert MacLeod

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 329-340; DOI: https://doi.org/10.1124/jpet.115.226969

Gastrointestinal, Hepatic, Pulmonary, and Renal

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PRD125, a Potent and Selective Inhibitor of Sterol O-Acyltransferase 2 Markedly Reduces Hepatic Cholesteryl Ester Accumulation and Improves Liver Function in Lysosomal Acid Lipase-Deficient Mice
Adam M. Lopez, Jen-Chieh Chuang, Kenneth S. Posey, Taichi Ohshiro, Hiroshi Tomoda, Lawrence L. Rudel and Stephen D. Turley

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 159-167; DOI: https://doi.org/10.1124/jpet.115.227207
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Acetazolamide Protects Steatotic Liver Grafts against Cold Ischemia Reperfusion Injury
Mohamed Bejaoui, Eirini Pantazi, Viviana De Luca, Arnau Panisello, Emma Folch-Puy, Anna Serafin, Clemente Capasso, Supuran C. T. and Joan Rosselló-Catafau

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 191-198; DOI: https://doi.org/10.1124/jpet.115.225177
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Role of µ, κ, and δ Opioid Receptors in Tibial Inhibition of Bladder Overactivity in Cats
Zhaocun Zhang, Richard C. Slater, Matthew C. Ferroni, Brian T. Kadow, Timothy D. Lyon, Bing Shen, Zhiying Xiao, Jicheng Wang, Audry Kang, James R. Roppolo, William C. de Groat and Changfeng Tai

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 228-234; DOI: https://doi.org/10.1124/jpet.115.226845

Inflammation, Immunopharmacology, and Asthma

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Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice
Qilu Fang, Liancheng Deng, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang and Guang Liang

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 235-246; DOI: https://doi.org/10.1124/jpet.115.226860

Metabolism, Transport, and Pharmacogenomics

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Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model
Karen E. Parrish, Jenny Pokorny, Rajendar K. Mittapalli, Katrina Bakken, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 264-271; DOI: https://doi.org/10.1124/jpet.115.228213

Neuropharmacology

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Interaction of CRF and Kappa Opioid Systems on GABAergic Neurotransmission in the Mouse Central Amygdala
Maenghee Kang-Park, Brigitte L. Kieffer, Amanda J. Roberts, George R. Siggins and Scott D. Moore

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 206-211; DOI: https://doi.org/10.1124/jpet.115.225870

Toxicology

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Altered Protein S-Glutathionylation Identifies a Potential Mechanism of Resistance to Acetaminophen-Induced Hepatotoxicity
David J. McGarry, Probir Chakravarty, C. Roland Wolf and Colin J. Henderson

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 137-144; DOI: https://doi.org/10.1124/jpet.115.227389
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Octreotide Inhibits the Bilirubin Carriers Organic Anion Transporting Polypeptides 1B1 and 1B3 and the Multidrug Resistance-Associated Protein 2
Michele Visentin, Bruno Stieger, Michael Merz and Gerd A. Kullak-Ublick

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 145-151; DOI: https://doi.org/10.1124/jpet.115.227546
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Elevated Glutathione Is Not Sufficient to Protect against Doxorubicin-Induced Nuclear Damage in Heart in Multidrug Resistance–Associated Protein 1 (Mrp1/Abcc1) Null Mice
Jun Deng, Donna Coy, Wei Zhang, Manjula Sunkara, Andrew J. Morris, Chi Wang, Luksana Chaiswing, Daret St. Clair, Mary Vore and Paiboon Jungsuwadee

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 272-279; DOI: https://doi.org/10.1124/jpet.115.225490
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Loss of Multidrug Resistance–Associated Protein 1 Potentiates Chronic Doxorubicin-Induced Cardiac Dysfunction in Mice
Wei Zhang, Jun Deng, Manjula Sunkara, Andrew J. Morris, Chi Wang, Daret St. Clair and Mary Vore

Journal of Pharmacology and Experimental Therapeutics November 2015, 355 (2) 280-287; DOI: https://doi.org/10.1124/jpet.115.225581

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Table of Contents

Highlighted Papers

Minireviews

Behavioral Pharmacology

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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