Journal of Pharmacology and Experimental Therapeutics: 355 (1)

October 01, 2015; Volume 355,Issue 1

Announcement

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Announcement
Mary Vore

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 135; DOI: https://doi.org/10.1124/jpet.115.229096

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Potent and Selective Inhibitors of Human Leukotriene C4 Synthase
Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 1; DOI: https://doi.org/10.1124/jpet.115.1015HIc
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Biodistribution Impacts Lung Anti-Inflammatory Efficacy of PKC-Delta Peptide
Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 1; DOI: https://doi.org/10.1124/jpet.115.1015HIb
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Sphingosine Kinase 2 Inhibition and Blood Sphingosine Kinase 1-Phosphate Levels
Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 1; DOI: https://doi.org/10.1124/jpet.115.1015HIa
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The Prodrug 4-Chlorokynurenine Causes Antidepressant Effects
Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 1; DOI: https://doi.org/10.1124/jpet.115.1015HI

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The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/Glycine_B-Site Inhibition
Panos Zanos, Sean C. Piantadosi, Hui-Qiu Wu, Heather J. Pribut, Matthew J. Dell, Adem Can, H. Ralph Snodgrass, Carlos A. Zarate, Robert Schwarcz and Todd D. Gould

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 76-85; DOI: https://doi.org/10.1124/jpet.115.225664

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Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide–High Angiotensin II–Induced Cardiovascular Injury
Luminita H. Pojoga, Tham M. Yao, Lauren A. Opsasnick, Waleed T. Siddiqui, Ossama M. Reslan, Gail K. Adler, Gordon H. Williams and Raouf A. Khalil

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 32-47; DOI: https://doi.org/10.1124/jpet.115.226043
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A Novel Arginase Inhibitor Derived from Scutellavia indica Restored Endothelial Function in ApoE-Null Mice Fed a High-Cholesterol Diet
Hye Mi Hwang, Jeong Hyung Lee, Byung Sun Min, Byeong Hwa Jeon, Kwang Lae Hoe, Young Myeong Kim and Sungwoo Ryoo

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 57-65; DOI: https://doi.org/10.1124/jpet.115.224592

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Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels
Yugesh Kharel, Emily A. Morris, Molly D. Congdon, Steven B. Thorpe, Jose L. Tomsig, Webster L. Santos and Kevin R. Lynch

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 23-31; DOI: https://doi.org/10.1124/jpet.115.225862

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Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains
Kurt Giles, David B. Berry, Carlo Condello, Ronald C. Hawley, Alejandra Gallardo-Godoy, Clifford Bryant, Abby Oehler, Manuel Elepano, Sumita Bhardwaj, Smita Patel, B. Michael Silber, Shenheng Guan, Stephen J. DeArmond, Adam R. Renslo and Stanley B. Prusiner

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 2-12; DOI: https://doi.org/10.1124/jpet.115.224659

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Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis
Irina G. Luzina, Virginia Lockatell, Nevins W. Todd, Pavel Kopach, Helen S. Pentikis and Sergei P. Atamas

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 13-22; DOI: https://doi.org/10.1124/jpet.115.224675
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MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux
Boris Tchernychev, Pei Ge, Marco M. Kessler, Robert M. Solinga, Derek Wachtel, Jenny V. Tobin, Sara R. Thomas, Craig E. Lunte, Angelika Fretzen, Gerhard Hannig, Alexander P. Bryant, Caroline B. Kurtz, Mark G. Currie and Inmaculada Silos-Santiago

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 48-56; DOI: https://doi.org/10.1124/jpet.115.224329
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The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats
Shao-Jung Hsu, Sun-Sang Wang, Teh-Ia Huo, Fa-Yauh Lee, Hui-Chun Huang, Ching-Chih Chang, I-Fang Hsin, Hsin-Ling Ho, Han-Chieh Lin and Shou-Dong Lee

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 117-124; DOI: https://doi.org/10.1124/jpet.115.225516

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HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid
Christeene G. Haj, Percy F. Sumariwalla, Lumír Hanuš, Natalya M. Kogan, Zhana Yektin, Raphael Mechoulam, Mark Feldmann and Ruth Gallily

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 66-75; DOI: https://doi.org/10.1124/jpet.115.226100
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Biodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury
Mark J. Mondrinos, Linda C. Knight, Paul A. Kennedy, Jichuan Wu, Matthew Kauffman, Sandy T. Baker, Marla R. Wolfson and Laurie E. Kilpatrick

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 86-98; DOI: https://doi.org/10.1124/jpet.115.224832
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Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C₄ Synthase
Thea K. Kleinschmidt, Martin Haraldsson, Devaraj Basavarajappa, Erik Lundeberg, Madhuranayaki Thulasingam, Maria Ekoff, Alexander Fauland, Christoph Lehmann, Astrid S. Kahnt, Lennart Lindbom and Jesper Z. Haeggström

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 108-116; DOI: https://doi.org/10.1124/jpet.115.227157

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P-Glycoprotein Transport of Neurotoxic Pesticides
Sarah E. Lacher, Kasse Skagen, Joachim Veit, Rachel Dalton and Erica L. Woodahl

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 99-107; DOI: https://doi.org/10.1124/jpet.115.226373
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The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis
Mei-Ling Hou, Chi-Hung Lin, Lie-Chwen Lin and Tung-Hu Tsai

Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 125-134; DOI: https://doi.org/10.1124/jpet.115.225763