Journal of Pharmacology and Experimental Therapeutics: 354 (3)

September 01, 2015; Volume 354,Issue 3

Highlighted Papers

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Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model
Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HIa
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Mathematical Modeling of Cellular Responses to Bortezomib
Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HIb
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Pregnane X Receptor-Humanized Mice and Acute Ethanol Hepatotoxicity
Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HIc
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Sildenafil Does Not Prevent Cardiomyocyte Remodeling Induced by AT₁R Signaling
Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HI

Minireviews

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Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation
Wakana Ohashi, Kohshi Hattori and Yuichi Hattori

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 240-250; DOI: https://doi.org/10.1124/jpet.115.225540
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The Pharmacological and Physiological Role of Multidrug-Resistant Protein 4
Jiagen Wen, Jianquan Luo, Weihua Huang, Jie Tang, Honghao Zhou and Wei Zhang

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 358-375; DOI: https://doi.org/10.1124/jpet.115.225656

Cardiovascular

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Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling
Julia Straubinger, Verena Schöttle, Nadja Bork, Hariharan Subramanian, Sarah Dünnes, Michael Russwurm, Meinrad Gawaz, Andreas Friebe, Mona Nemer, Viacheslav O. Nikolaev and Robert Lukowski

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 406-416; DOI: https://doi.org/10.1124/jpet.115.226092

Cellular and Molecular

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Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines
Dhilushi D. Wijayakumara, Dong Gui Hu, Robyn Meech, Ross A. McKinnon and Peter I. Mackenzie

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 417-425; DOI: https://doi.org/10.1124/jpet.115.226118

Chemotherapy, Antibiotics, and Gene Therapy

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Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection
Ali Ramezani, Larisa Dubrovsky, Tatiana Pushkarsky, Dmitri Sviridov, Sara Karandish, Dominic S. Raj, Michael L. Fitzgerald and Michael Bukrinsky

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 376-383; DOI: https://doi.org/10.1124/jpet.115.224485
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The Inhibitor Ko143 Is Not Specific for ABCG2
Lora D. Weidner, Sami S. Zoghbi, Shuiyu Lu, Suneet Shukla, Suresh V. Ambudkar, Victor W. Pike, Jan Mulder, Michael M. Gottesman, Robert B. Innis and Matthew D. Hall

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 384-393; DOI: https://doi.org/10.1124/jpet.115.225482
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Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model
Misaki Nakajima, Shotaro Nagase, Manami Iida, Shuji Takeda, Mayo Yamashita, Akihiro Watari, Yoshitaka Shirasago, Masayoshi Fukasawa, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyohito Yagi and Masuo Kondoh

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 440-447; DOI: https://doi.org/10.1124/jpet.115.225391
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Logic-Based and Cellular Pharmacodynamic Modeling of Bortezomib Responses in U266 Human Myeloma Cells
Vaishali L. Chudasama, Meric A. Ovacik, Darrell R. Abernethy and Donald E. Mager

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 448-458; DOI: https://doi.org/10.1124/jpet.115.224766

Drug Discovery and Translational Medicine

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A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons
Marcelo D. Rosato-Siri, Erika Zambello, Chiara Mutinelli, Nicoletta Garbati, Roberto Benedetti, Laura Aldegheri, Francesca Graziani, Caterina Virginio, Giuseppe Alvaro and Charles H. Large

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 251-260; DOI: https://doi.org/10.1124/jpet.115.225748
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Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma
Mei-Hong Li, Rolf Swenson, Miriam Harel, Sampa Jana, Erik Stolarzewicz, Timothy Hla, Linda H. Shapiro and Fernando Ferrer

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 261-268; DOI: https://doi.org/10.1124/jpet.115.224519
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Orally Administered Mucolytic Drug l-Carbocisteine Inhibits Angiogenesis and Tumor Growth in Mice
Tomohiro Shinya, Tsubasa Yokota, Shiori Nakayama, Sayuri Oki, Junpei Mutoh, Satoru Takahashi and Keizo Sato

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 269-278; DOI: https://doi.org/10.1124/jpet.115.224816
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Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
Pascal Bonaventure, Jonathan Shelton, Sujin Yun, Diane Nepomuceno, Steven Sutton, Leah Aluisio, Ian Fraser, Brian Lord, James Shoblock, Natalie Welty, Sandra R. Chaplan, Zuleima Aguilar, Robin Halter, Anthony Ndifor, Tatiana Koudriakova, Michele Rizzolio, Michael Letavic, Nicholas I. Carruthers, Timothy Lovenberg and Christine Dugovic

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 471-482; DOI: https://doi.org/10.1124/jpet.115.225466
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Dopamine D₃ Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs
Nathan M. Appel, Shou-Hua Li, Tyson H. Holmes and Jane B. Acri

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 484-492; DOI: https://doi.org/10.1124/jpet.115.224121

Endocrine and Diabetes

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Intestinal Sodium Glucose Cotransporter 1 Inhibition Enhances Glucagon-Like Peptide-1 Secretion in Normal and Diabetic Rodents
Takahiro Oguma, Keiko Nakayama, Chiaki Kuriyama, Yasuaki Matsushita, Kumiko Yoshida, Kumiko Hikida, Naoyuki Obokata, Minoru Tsuda-Tsukimoto, Akira Saito, Kenji Arakawa, Kiichiro Ueta and Masaharu Shiotani

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 279-289; DOI: https://doi.org/10.1124/jpet.115.225508

Gastrointestinal, Hepatic, Pulmonary, and Renal

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The Novel K_V7.2/K_V7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
Aaron Provence, John Malysz and Georgi V. Petkov

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 290-301; DOI: https://doi.org/10.1124/jpet.115.225268
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High-Mobility Group Box 1 Mediates Epithelial-to-Mesenchymal Transition in Pulmonary Fibrosis Involving Transforming Growth Factor-β1/Smad2/3 Signaling
Liu-Cheng Li, De-Lin Li, Liang Xu, Xiao-Ting Mo, Wen-Hui Cui, Ping Zhao, Wen-Cheng Zhou, Jian Gao and Jun Li

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 302-309; DOI: https://doi.org/10.1124/jpet.114.222372
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Pregnane X Receptor–Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity
Krisstonia Spruiell, Afua A. Gyamfi, Susan T. Yeyeodu, Ricardo M. Richardson, Frank J. Gonzalez and Maxwell A. Gyamfi

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 459-470; DOI: https://doi.org/10.1124/jpet.115.224295

Inflammation, Immunopharmacology, and Asthma

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Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis
Tomoki Fukuyama, Sarah Ehling, Elizabeth Cook and Wolfgang Bäumer

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 394-405; DOI: https://doi.org/10.1124/jpet.115.223784

Metabolism, Transport, and Pharmacogenomics

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Marked Alteration of Rosuvastatin Pharmacokinetics in Healthy Chinese with ABCG2 34G>A and 421C>A Homozygote or Compound Heterozygote
Zirui Wan, Guo Wang, Tailin Li, Biaobo Xu, Qi Pei, Yan Peng, Hong Sun, Lijuan Cheng, Ying Zeng, Guoping Yang and Yuan-Shan Zhu

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 310-315; DOI: https://doi.org/10.1124/jpet.115.225045
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CYP2C19 Phenoconversion by Routinely Prescribed Proton Pump Inhibitors Omeprazole and Esomeprazole: Clinical Implications for Personalized Medicine
Martin Klieber, Herbert Oberacher, Silvia Hofstaetter, Beate Beer, Martin Neururer, Anton Amann, Hannes Alber and Anil Modak

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 426-430; DOI: https://doi.org/10.1124/jpet.115.225680

Neuropharmacology

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Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ⁹-Tetrahydrocannabinol–Mediated Induction of ΔFosB in the Mouse Forebrain
Matthew F. Lazenka, Aaron J. Tomarchio, Aron H. Lichtman, Paul Greengard, Marc Flajolet, Dana E. Selley and Laura J. Sim-Selley

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 316-327; DOI: https://doi.org/10.1124/jpet.115.224428
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AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ⁹-Tetrahydrocannabinol–Like Effects in Mice
Jenny L. Wiley, Julie A. Marusich, Timothy W. Lefever, Kateland R. Antonazzo, Michael T. Wallgren, Ricardo A. Cortes, Purvi R. Patel, Megan Grabenauer, Katherine N. Moore and Brian F. Thomas

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 328-339; DOI: https://doi.org/10.1124/jpet.115.225326
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Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity
Martin A. Lewis, Lisa Hunihan, John Watson, Robert G. Gentles, Shuanghua Hu, Yazhong Huang, Joanne Bronson, John E. Macor, Brett R. Beno, Meredith Ferrante, Adam Hendricson, Ronald J. Knox, Thaddeus F. Molski, Yan Kong, Mary Ellen Cvijic, Kristin L. Rockwell, Michael R. Weed, Angela M. Cacace, Ryan S. Westphal, Andrew Alt and Jeffrey M. Brown

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 340-349; DOI: https://doi.org/10.1124/jpet.115.224071
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Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model
Steve Vermeersch, Robert J. Benschop, Anne Van Hecken, David Monteith, Victor J. Wroblewski, David Grayzel, Jan de Hoon and Emily C. Collins

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 350-357; DOI: https://doi.org/10.1124/jpet.115.224212
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Activation of Mas Oncogene-Related G Protein–Coupled Receptors Inhibits Neurochemical Alterations in the Spinal Dorsal Horn and Dorsal Root Ganglia Associated with Inflammatory Pain in Rats
Dongmei Wang, Peizhong Wang, Jianping Jiang, Qingqin Lv, Xueai Zeng and Yanguo Hong

Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 431-439; DOI: https://doi.org/10.1124/jpet.115.225672

Erratum

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Correction to “The Minimal Pharmacophore for Silent Agonism of the α ₇ Nicotinic Acetylcholine Receptor”
Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 483; DOI: https://doi.org/10.1124/jpet.115.215236err

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Table of Contents

Highlighted Papers

Minireviews

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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