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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2015; Volume 354,Issue 3

Highlighted Papers

  • You have access
    Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HIa
  • You have access
    Mathematical Modeling of Cellular Responses to Bortezomib
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HIb
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    Pregnane X Receptor-Humanized Mice and Acute Ethanol Hepatotoxicity
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HIc
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    Sildenafil Does Not Prevent Cardiomyocyte Remodeling Induced by AT1R Signaling
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 239; DOI: https://doi.org/10.1124/jpet.115.0915HI

Minireviews

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    Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation
    Wakana Ohashi, Kohshi Hattori and Yuichi Hattori
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 240-250; DOI: https://doi.org/10.1124/jpet.115.225540
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    The Pharmacological and Physiological Role of Multidrug-Resistant Protein 4
    Jiagen Wen, Jianquan Luo, Weihua Huang, Jie Tang, Honghao Zhou and Wei Zhang
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 358-375; DOI: https://doi.org/10.1124/jpet.115.225656

Cardiovascular

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    Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling
    Julia Straubinger, Verena Schöttle, Nadja Bork, Hariharan Subramanian, Sarah Dünnes, Michael Russwurm, Meinrad Gawaz, Andreas Friebe, Mona Nemer, Viacheslav O. Nikolaev and Robert Lukowski
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 406-416; DOI: https://doi.org/10.1124/jpet.115.226092

Cellular and Molecular

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    Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines
    Dhilushi D. Wijayakumara, Dong Gui Hu, Robyn Meech, Ross A. McKinnon and Peter I. Mackenzie
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 417-425; DOI: https://doi.org/10.1124/jpet.115.226118

Chemotherapy, Antibiotics, and Gene Therapy

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    Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection
    Ali Ramezani, Larisa Dubrovsky, Tatiana Pushkarsky, Dmitri Sviridov, Sara Karandish, Dominic S. Raj, Michael L. Fitzgerald and Michael Bukrinsky
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 376-383; DOI: https://doi.org/10.1124/jpet.115.224485
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    The Inhibitor Ko143 Is Not Specific for ABCG2
    Lora D. Weidner, Sami S. Zoghbi, Shuiyu Lu, Suneet Shukla, Suresh V. Ambudkar, Victor W. Pike, Jan Mulder, Michael M. Gottesman, Robert B. Innis and Matthew D. Hall
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 384-393; DOI: https://doi.org/10.1124/jpet.115.225482
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    Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model
    Misaki Nakajima, Shotaro Nagase, Manami Iida, Shuji Takeda, Mayo Yamashita, Akihiro Watari, Yoshitaka Shirasago, Masayoshi Fukasawa, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyohito Yagi and Masuo Kondoh
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 440-447; DOI: https://doi.org/10.1124/jpet.115.225391
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    Logic-Based and Cellular Pharmacodynamic Modeling of Bortezomib Responses in U266 Human Myeloma Cells
    Vaishali L. Chudasama, Meric A. Ovacik, Darrell R. Abernethy and Donald E. Mager
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 448-458; DOI: https://doi.org/10.1124/jpet.115.224766

Drug Discovery and Translational Medicine

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    A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons
    Marcelo D. Rosato-Siri, Erika Zambello, Chiara Mutinelli, Nicoletta Garbati, Roberto Benedetti, Laura Aldegheri, Francesca Graziani, Caterina Virginio, Giuseppe Alvaro and Charles H. Large
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 251-260; DOI: https://doi.org/10.1124/jpet.115.225748
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    Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma
    Mei-Hong Li, Rolf Swenson, Miriam Harel, Sampa Jana, Erik Stolarzewicz, Timothy Hla, Linda H. Shapiro and Fernando Ferrer
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 261-268; DOI: https://doi.org/10.1124/jpet.115.224519
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    Orally Administered Mucolytic Drug l-Carbocisteine Inhibits Angiogenesis and Tumor Growth in Mice
    Tomohiro Shinya, Tsubasa Yokota, Shiori Nakayama, Sayuri Oki, Junpei Mutoh, Satoru Takahashi and Keizo Sato
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 269-278; DOI: https://doi.org/10.1124/jpet.115.224816
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    Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
    Pascal Bonaventure, Jonathan Shelton, Sujin Yun, Diane Nepomuceno, Steven Sutton, Leah Aluisio, Ian Fraser, Brian Lord, James Shoblock, Natalie Welty, Sandra R. Chaplan, Zuleima Aguilar, Robin Halter, Anthony Ndifor, Tatiana Koudriakova, Michele Rizzolio, Michael Letavic, Nicholas I. Carruthers, Timothy Lovenberg and Christine Dugovic
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 471-482; DOI: https://doi.org/10.1124/jpet.115.225466
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    Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs
    Nathan M. Appel, Shou-Hua Li, Tyson H. Holmes and Jane B. Acri
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 484-492; DOI: https://doi.org/10.1124/jpet.115.224121

Endocrine and Diabetes

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    Intestinal Sodium Glucose Cotransporter 1 Inhibition Enhances Glucagon-Like Peptide-1 Secretion in Normal and Diabetic Rodents
    Takahiro Oguma, Keiko Nakayama, Chiaki Kuriyama, Yasuaki Matsushita, Kumiko Yoshida, Kumiko Hikida, Naoyuki Obokata, Minoru Tsuda-Tsukimoto, Akira Saito, Kenji Arakawa, Kiichiro Ueta and Masaharu Shiotani
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 279-289; DOI: https://doi.org/10.1124/jpet.115.225508

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
    Aaron Provence, John Malysz and Georgi V. Petkov
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 290-301; DOI: https://doi.org/10.1124/jpet.115.225268
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    High-Mobility Group Box 1 Mediates Epithelial-to-Mesenchymal Transition in Pulmonary Fibrosis Involving Transforming Growth Factor-β1/Smad2/3 Signaling
    Liu-Cheng Li, De-Lin Li, Liang Xu, Xiao-Ting Mo, Wen-Hui Cui, Ping Zhao, Wen-Cheng Zhou, Jian Gao and Jun Li
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 302-309; DOI: https://doi.org/10.1124/jpet.114.222372
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    Pregnane X Receptor–Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity
    Krisstonia Spruiell, Afua A. Gyamfi, Susan T. Yeyeodu, Ricardo M. Richardson, Frank J. Gonzalez and Maxwell A. Gyamfi
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 459-470; DOI: https://doi.org/10.1124/jpet.115.224295

Inflammation, Immunopharmacology, and Asthma

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    Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis
    Tomoki Fukuyama, Sarah Ehling, Elizabeth Cook and Wolfgang Bäumer
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 394-405; DOI: https://doi.org/10.1124/jpet.115.223784

Metabolism, Transport, and Pharmacogenomics

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    Marked Alteration of Rosuvastatin Pharmacokinetics in Healthy Chinese with ABCG2 34G>A and 421C>A Homozygote or Compound Heterozygote
    Zirui Wan, Guo Wang, Tailin Li, Biaobo Xu, Qi Pei, Yan Peng, Hong Sun, Lijuan Cheng, Ying Zeng, Guoping Yang and Yuan-Shan Zhu
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 310-315; DOI: https://doi.org/10.1124/jpet.115.225045
  • You have access
    CYP2C19 Phenoconversion by Routinely Prescribed Proton Pump Inhibitors Omeprazole and Esomeprazole: Clinical Implications for Personalized Medicine
    Martin Klieber, Herbert Oberacher, Silvia Hofstaetter, Beate Beer, Martin Neururer, Anton Amann, Hannes Alber and Anil Modak
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 426-430; DOI: https://doi.org/10.1124/jpet.115.225680

Neuropharmacology

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    Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol–Mediated Induction of ΔFosB in the Mouse Forebrain
    Matthew F. Lazenka, Aaron J. Tomarchio, Aron H. Lichtman, Paul Greengard, Marc Flajolet, Dana E. Selley and Laura J. Sim-Selley
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 316-327; DOI: https://doi.org/10.1124/jpet.115.224428
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    AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol–Like Effects in Mice
    Jenny L. Wiley, Julie A. Marusich, Timothy W. Lefever, Kateland R. Antonazzo, Michael T. Wallgren, Ricardo A. Cortes, Purvi R. Patel, Megan Grabenauer, Katherine N. Moore and Brian F. Thomas
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 328-339; DOI: https://doi.org/10.1124/jpet.115.225326
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    Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity
    Martin A. Lewis, Lisa Hunihan, John Watson, Robert G. Gentles, Shuanghua Hu, Yazhong Huang, Joanne Bronson, John E. Macor, Brett R. Beno, Meredith Ferrante, Adam Hendricson, Ronald J. Knox, Thaddeus F. Molski, Yan Kong, Mary Ellen Cvijic, Kristin L. Rockwell, Michael R. Weed, Angela M. Cacace, Ryan S. Westphal, Andrew Alt and Jeffrey M. Brown
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 340-349; DOI: https://doi.org/10.1124/jpet.115.224071
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    Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model
    Steve Vermeersch, Robert J. Benschop, Anne Van Hecken, David Monteith, Victor J. Wroblewski, David Grayzel, Jan de Hoon and Emily C. Collins
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 350-357; DOI: https://doi.org/10.1124/jpet.115.224212
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    Activation of Mas Oncogene-Related G Protein–Coupled Receptors Inhibits Neurochemical Alterations in the Spinal Dorsal Horn and Dorsal Root Ganglia Associated with Inflammatory Pain in Rats
    Dongmei Wang, Peizhong Wang, Jianping Jiang, Qingqin Lv, Xueai Zeng and Yanguo Hong
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 431-439; DOI: https://doi.org/10.1124/jpet.115.225672

Erratum

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    Correction to “The Minimal Pharmacophore for Silent Agonism of the α 7 Nicotinic Acetylcholine Receptor”
    Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 483; DOI: https://doi.org/10.1124/jpet.115.215236err
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Journal of Pharmacology and Experimental Therapeutics: 354 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 354, Issue 3
1 Sep 2015
  • Table of Contents
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  • Highlighted Papers
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  • Cardiovascular
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  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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