Research ArticleToxicology
A Cytochrome P450–Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes
Kazuhisa Miyakawa, Ryan Albee, Lynda G. Letzig, Andreas F. Lehner, Michael A. Scott, John P. Buchweitz, Laura P. James, Patricia E. Ganey and Robert A. Roth
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 230-237; DOI: https://doi.org/10.1124/jpet.115.223537
Kazuhisa Miyakawa
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Ryan Albee
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Lynda G. Letzig
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Andreas F. Lehner
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Michael A. Scott
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
John P. Buchweitz
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Laura P. James
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Patricia E. Ganey
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
Robert A. Roth
Department of Pathobiology and Diagnostic Investigation (K.M., M.A.S., J.P.B.), Department of Pharmacology and Toxicology, Institute for Integrative Toxicology (R.A., P.E.G., R.A.R.), and Diagnostic Center for Population and Animal Health, Section of Toxicology (A.F.L.), Michigan State University, East Lansing, Michigan; and Department of Pediatrics, University of Arkansas for Medical Sciences and Clinical Pharmacology and Toxicology Section, Arkansas Children’s Hospital, Little Rock, Arkansas (L.G.L., L.P.J.)
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In this issue
Research ArticleToxicology
P450-Independent APAP Hepatocellular Injury In Vitro
Kazuhisa Miyakawa, Ryan Albee, Lynda G. Letzig, Andreas F. Lehner, Michael A. Scott, John P. Buchweitz, Laura P. James, Patricia E. Ganey and Robert A. Roth
Journal of Pharmacology and Experimental Therapeutics August 1, 2015, 354 (2) 230-237; DOI: https://doi.org/10.1124/jpet.115.223537
Research ArticleToxicology
P450-Independent APAP Hepatocellular Injury In Vitro
Kazuhisa Miyakawa, Ryan Albee, Lynda G. Letzig, Andreas F. Lehner, Michael A. Scott, John P. Buchweitz, Laura P. James, Patricia E. Ganey and Robert A. Roth
Journal of Pharmacology and Experimental Therapeutics August 1, 2015, 354 (2) 230-237; DOI: https://doi.org/10.1124/jpet.115.223537
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