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Research ArticleDrug Discovery and Translational Medicine

The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism

Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets and Pablo V. Escribá
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 213-224; DOI: https://doi.org/10.1124/jpet.114.222281
Francisca Guardiola-Serrano
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Roberto Beteta-Göbel
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Raquel Rodríguez-Lorca
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Maitane Ibarguren
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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David J. López
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Silvia Terés
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Rafael Alvarez
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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María Alonso-Sande
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Xavier Busquets
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Pablo V. Escribá
Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
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Article Information

vol. 354 no. 2 213-224
DOI 
https://doi.org/10.1124/jpet.114.222281
PubMed 
26065701

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 22, 2014
  • Accepted June 9, 2015
  • Published online July 2, 2015.

Article Versions

  • Earlier version (June 11, 2015 - 12:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Francisca Guardiola-Serrano,
  2. Roberto Beteta-Göbel,
  3. Raquel Rodríguez-Lorca,
  4. Maitane Ibarguren,
  5. David J. López,
  6. Silvia Terés,
  7. Rafael Alvarez,
  8. María Alonso-Sande,
  9. Xavier Busquets, and
  10. Pablo V. Escribá
  1. Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain (F.G.-S., R.B.-G., R.R.-L., M.I., D.J.L., S.T., R.A., M.A.-S., X.B., P.V.E.); and Lipopharma Therapeutics S.L., Palma de Mallorca, Spain (M.I., D.J.L., S.T., R.A., M.A.-S.).
  1. Address correspondence to:
    Dr. Francisca Guardiola-Serrano, Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, E-07122 Palma, Palma de Mallorca, Spain. E-mail: franciscaguardiola{at}uib.es
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Journal of Pharmacology and Experimental Therapeutics: 354 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 354, Issue 2
1 Aug 2015
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Research ArticleDrug Discovery and Translational Medicine

HTO Inhibits Lung Cancer Cell Proliferation.

Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets and Pablo V. Escribá
Journal of Pharmacology and Experimental Therapeutics August 1, 2015, 354 (2) 213-224; DOI: https://doi.org/10.1124/jpet.114.222281

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Research ArticleDrug Discovery and Translational Medicine

HTO Inhibits Lung Cancer Cell Proliferation.

Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets and Pablo V. Escribá
Journal of Pharmacology and Experimental Therapeutics August 1, 2015, 354 (2) 213-224; DOI: https://doi.org/10.1124/jpet.114.222281
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