Journal of Pharmacology and Experimental Therapeutics: 354 (2)

August 01, 2015; Volume 354,Issue 2

Highlighted Papers

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Behavioral Pharmacology of Synthetic Cathinones
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HI
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Monocarboxylate Transporter Subtype 1 Mediated Uptake of HOCPCA
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HIb
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Transient Receptor Potential Channel Opening Releases Acetylcholine, Which Can Lead to Vasodilation
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HIa
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Cytochrome P450–Independent Acetaminophen-Induced Injury in Mouse Hepatocytes
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HIc

Minireview

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The Ins and Outs of Small GTPase Rac1 in the Vasculature
Goran Marinković, Niels Heemskerk, Jaap D. van Buul and Vivian de Waard

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 91-102; DOI: https://doi.org/10.1124/jpet.115.223610

Behavioral Pharmacology

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Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives
Michael B. Gatch, Sean B. Dolan and Michael J. Forster

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 103-110; DOI: https://doi.org/10.1124/jpet.115.223586
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Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice
Sudeshna Ghosh, Steven G. Kinsey, Qing-song Liu, Lenka Hruba, Lance R. McMahon, Travis W. Grim, Christina R. Merritt, Laura E. Wise, Rehab A. Abdullah, Dana E. Selley, Laura J. Sim-Selley, Benjamin F. Cravatt and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 111-120; DOI: https://doi.org/10.1124/jpet.115.222851

Cardiovascular

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Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries
Q. Zou, S. W. S. Leung and P. M. Vanhoutte

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 121-130; DOI: https://doi.org/10.1124/jpet.115.223693

Chemotherapy, Antibiotics, and Gene Therapy

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Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity
Hilary Nicholson, Anthony Comeau, Christophe Mesangeau, Christopher R. McCurdy and Wayne D. Bowen

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 203-212; DOI: https://doi.org/10.1124/jpet.115.224105

Drug Discovery and Translational Medicine

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Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization
Wei-Peng Wang, Pui Yan Ho, Qiu-Xia Chen, Balasubrahmanyam Addepalli, Patrick A. Limbach, Mei-Mei Li, Wen-Juan Wu, Joseph L. Jilek, Jing-Xin Qiu, Hong-Jian Zhang, Tianhong Li, Theodore Wun, Ralph DeVere White, Kit S. Lam and Ai-Ming Yu

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 131-141; DOI: https://doi.org/10.1124/jpet.115.225631
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The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism
Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets and Pablo V. Escribá

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 213-224; DOI: https://doi.org/10.1124/jpet.114.222281

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis
Murugavel Ponnusamy, Michelle A. Zhuang, Xiaoxu Zhou, Evelyn Tolbert, George Bayliss, Ting C. Zhao and Shougang Zhuang

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 142-151; DOI: https://doi.org/10.1124/jpet.115.224386

Inflammation, Immunopharmacology, and Asthma

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Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity
Paul R. Mangan, Linhui Julie Su, Victoria Jenny, Andrea L. Tatum, Caryn Picarillo, Stacey Skala, Noah Ditto, Zheng Lin, XiaoXia Yang, Pete Z. Cotter, David J. Shuster, Yunling Song, Virna Borowski, Rochelle L. Thomas, Elizabeth M. Heimrich, Brigitte Devaux, Ruchira Das Gupta, Irvith Carvajal, Kim W. McIntyre, Jenny Xie, Qihong Zhao, Mary Struthers and Luisa M. Salter-Cid

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 152-165; DOI: https://doi.org/10.1124/jpet.115.224246

Metabolism, Transport, and Pharmacogenomics

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Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity
Fang Xie, Alice B. Ke, Gary D. Bowers and Maciej J. Zamek-Gliszczynski

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 225-229; DOI: https://doi.org/10.1124/jpet.115.225698

Neuropharmacology

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In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1
Louise Thiesen, Jan Kehler, Rasmus P. Clausen, Bente Frølund, Christoffer Bundgaard and Petrine Wellendorph

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 166-174; DOI: https://doi.org/10.1124/jpet.115.224543
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Schwann Cells Metabolize Extracellular 2′,3′-cAMP to 2′-AMP
Jonathan D. Verrier, Patrick M. Kochanek and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 175-183; DOI: https://doi.org/10.1124/jpet.115.225219
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Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit
Maegan M. Weltzin and Marvin K. Schulte

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 184-194; DOI: https://doi.org/10.1124/jpet.115.223933

Toxicology

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Phototoxic Risk Assessments on Benzophenone Derivatives: Photobiochemical Assessments and Dermal Cassette-Dosing Pharmacokinetic Study
Yoshiki Seto, Hiroto Ohtake, Masashi Kato and Satomi Onoue

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 195-202; DOI: https://doi.org/10.1124/jpet.115.223644
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A Cytochrome P450–Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes
Kazuhisa Miyakawa, Ryan Albee, Lynda G. Letzig, Andreas F. Lehner, Michael A. Scott, John P. Buchweitz, Laura P. James, Patricia E. Ganey and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 230-237; DOI: https://doi.org/10.1124/jpet.115.223537

Addendum

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Addendum to “An Engineered Human Follistatin Variant: Insights into the Pharmacokinetic and Pharmocodynamic Relationships of a Novel Molecule with Broad Therapeutic Potential”
Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 238; DOI: https://doi.org/10.1124/jpet.115.201491add

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Table of Contents

Highlighted Papers

Minireview

Behavioral Pharmacology

Cardiovascular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Addendum

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