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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2015; Volume 354,Issue 2

Highlighted Papers

  • You have access
    Behavioral Pharmacology of Synthetic Cathinones
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HI
  • You have access
    Monocarboxylate Transporter Subtype 1 Mediated Uptake of HOCPCA
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HIb
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    Transient Receptor Potential Channel Opening Releases Acetylcholine, Which Can Lead to Vasodilation
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HIa
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    Cytochrome P450–Independent Acetaminophen-Induced Injury in Mouse Hepatocytes
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 90; DOI: https://doi.org/10.1124/jpet.115.0815HIc

Minireview

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    The Ins and Outs of Small GTPase Rac1 in the Vasculature
    Goran Marinković, Niels Heemskerk, Jaap D. van Buul and Vivian de Waard
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 91-102; DOI: https://doi.org/10.1124/jpet.115.223610

Behavioral Pharmacology

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    Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives
    Michael B. Gatch, Sean B. Dolan and Michael J. Forster
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 103-110; DOI: https://doi.org/10.1124/jpet.115.223586
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    Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice
    Sudeshna Ghosh, Steven G. Kinsey, Qing-song Liu, Lenka Hruba, Lance R. McMahon, Travis W. Grim, Christina R. Merritt, Laura E. Wise, Rehab A. Abdullah, Dana E. Selley, Laura J. Sim-Selley, Benjamin F. Cravatt and Aron H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 111-120; DOI: https://doi.org/10.1124/jpet.115.222851

Cardiovascular

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    Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries
    Q. Zou, S. W. S. Leung and P. M. Vanhoutte
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 121-130; DOI: https://doi.org/10.1124/jpet.115.223693

Chemotherapy, Antibiotics, and Gene Therapy

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    Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity
    Hilary Nicholson, Anthony Comeau, Christophe Mesangeau, Christopher R. McCurdy and Wayne D. Bowen
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 203-212; DOI: https://doi.org/10.1124/jpet.115.224105

Drug Discovery and Translational Medicine

  • Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization
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    Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization
    Wei-Peng Wang, Pui Yan Ho, Qiu-Xia Chen, Balasubrahmanyam Addepalli, Patrick A. Limbach, Mei-Mei Li, Wen-Juan Wu, Joseph L. Jilek, Jing-Xin Qiu, Hong-Jian Zhang, Tianhong Li, Theodore Wun, Ralph DeVere White, Kit S. Lam and Ai-Ming Yu
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 131-141; DOI: https://doi.org/10.1124/jpet.115.225631
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    The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism
    Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets and Pablo V. Escribá
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 213-224; DOI: https://doi.org/10.1124/jpet.114.222281

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis
    Murugavel Ponnusamy, Michelle A. Zhuang, Xiaoxu Zhou, Evelyn Tolbert, George Bayliss, Ting C. Zhao and Shougang Zhuang
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 142-151; DOI: https://doi.org/10.1124/jpet.115.224386

Inflammation, Immunopharmacology, and Asthma

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    Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity
    Paul R. Mangan, Linhui Julie Su, Victoria Jenny, Andrea L. Tatum, Caryn Picarillo, Stacey Skala, Noah Ditto, Zheng Lin, XiaoXia Yang, Pete Z. Cotter, David J. Shuster, Yunling Song, Virna Borowski, Rochelle L. Thomas, Elizabeth M. Heimrich, Brigitte Devaux, Ruchira Das Gupta, Irvith Carvajal, Kim W. McIntyre, Jenny Xie, Qihong Zhao, Mary Struthers and Luisa M. Salter-Cid
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 152-165; DOI: https://doi.org/10.1124/jpet.115.224246

Metabolism, Transport, and Pharmacogenomics

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    Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity
    Fang Xie, Alice B. Ke, Gary D. Bowers and Maciej J. Zamek-Gliszczynski
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 225-229; DOI: https://doi.org/10.1124/jpet.115.225698

Neuropharmacology

  • In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1
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    In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1
    Louise Thiesen, Jan Kehler, Rasmus P. Clausen, Bente Frølund, Christoffer Bundgaard and Petrine Wellendorph
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 166-174; DOI: https://doi.org/10.1124/jpet.115.224543
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    Schwann Cells Metabolize Extracellular 2′,3′-cAMP to 2′-AMP
    Jonathan D. Verrier, Patrick M. Kochanek and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 175-183; DOI: https://doi.org/10.1124/jpet.115.225219
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    Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit
    Maegan M. Weltzin and Marvin K. Schulte
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 184-194; DOI: https://doi.org/10.1124/jpet.115.223933

Toxicology

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    Phototoxic Risk Assessments on Benzophenone Derivatives: Photobiochemical Assessments and Dermal Cassette-Dosing Pharmacokinetic Study
    Yoshiki Seto, Hiroto Ohtake, Masashi Kato and Satomi Onoue
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 195-202; DOI: https://doi.org/10.1124/jpet.115.223644
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    A Cytochrome P450–Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes
    Kazuhisa Miyakawa, Ryan Albee, Lynda G. Letzig, Andreas F. Lehner, Michael A. Scott, John P. Buchweitz, Laura P. James, Patricia E. Ganey and Robert A. Roth
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 230-237; DOI: https://doi.org/10.1124/jpet.115.223537

Addendum

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    Addendum to “An Engineered Human Follistatin Variant: Insights into the Pharmacokinetic and Pharmocodynamic Relationships of a Novel Molecule with Broad Therapeutic Potential”
    Journal of Pharmacology and Experimental Therapeutics August 2015, 354 (2) 238; DOI: https://doi.org/10.1124/jpet.115.201491add
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 354 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 354, Issue 2
1 Aug 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Highlighted Papers
  • Minireview
  • Behavioral Pharmacology
  • Cardiovascular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Toxicology
  • Addendum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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