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Research ArticleMinireviews

Activators of G Protein Signaling in the Kidney

Frank Park
Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 235-245; DOI: https://doi.org/10.1124/jpet.115.222695
Frank Park
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee
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Abstract

Heterotrimeric G proteins play a crucial role in regulating signal processing to maintain normal cellular homeostasis, and subtle perturbations in its activity can potentially lead to the pathogenesis of renal disorders or diseases. Cell-surface receptors and accessory proteins, which normally modify and organize the coupling of individual G protein subunits, contribute to the regulation of heterotrimeric G protein activity and their convergence and/or divergence of downstream signaling initiated by effector systems. Activators of G protein signaling (AGS) are a family of accessory proteins that intervene at multiple distinct points during the activation–inactivation cycle of G proteins, even in the absence of receptor stimulation. Perturbations in the expression of individual AGS proteins have been reported to modulate signal transduction pathways in a wide array of diseases and disorders within the brain, heart, immune system, and more recently, the kidney. This review will provide an overview of the expression profile, localization, and putative biologic role of the AGS family in the context of normal and diseased states of the kidney.

Footnotes

    • Received January 6, 2015.
    • Accepted January 23, 2015.
  • This research was supported by the National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases [Grant R01-DK09123] and institutional funds.

  • dx.doi.org/10.1124/jpet.115.222695.

  • Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 353 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 353, Issue 2
1 May 2015
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Research ArticleMinireviews

AGS in the Kidney

Frank Park
Journal of Pharmacology and Experimental Therapeutics May 1, 2015, 353 (2) 235-245; DOI: https://doi.org/10.1124/jpet.115.222695

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Research ArticleMinireviews

AGS in the Kidney

Frank Park
Journal of Pharmacology and Experimental Therapeutics May 1, 2015, 353 (2) 235-245; DOI: https://doi.org/10.1124/jpet.115.222695
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