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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2015; Volume 353,Issue 2

Highlighted Papers

  • You have access
    MPO Inhibition Prevents Immune Complex Vasculitis and Anti–Glomerular Basement Membrane Diseases
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 234; DOI: https://doi.org/10.1124/jpet.115.0515HI
  • You have access
    Antialbuminuric Effects of the Angiotensin-Converting Enzyme Inhibitor Enalapril
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 234; DOI: https://doi.org/10.1124/jpet.115.0515HIa
  • You have access
    The Novel Action of the Prostaglandin I2 Mimetic ONO-1301 on Platelet Aggregation
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 234; DOI: https://doi.org/10.1124/jpet.115.0515HIb
  • You have access
    Simultaneous Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 234; DOI: https://doi.org/10.1124/jpet.115.0515HIc

Minireviews

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    Activators of G Protein Signaling in the Kidney
    Frank Park
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 235-245; DOI: https://doi.org/10.1124/jpet.115.222695
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    Endogenous Allosteric Modulators of G Protein–Coupled Receptors
    Emma T. van der Westhuizen, Celine Valant, Patrick M. Sexton and Arthur Christopoulos
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 246-260; DOI: https://doi.org/10.1124/jpet.114.221606
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    Innate Immune Modulation in Chronic Obstructive Pulmonary Disease: Moving Closer toward Vitamin D Therapy
    Nele Heulens, Hannelie Korf and Wim Janssens
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 360-368; DOI: https://doi.org/10.1124/jpet.115.223032

Behavioral Pharmacology

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    Simultaneous Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Shares Discriminative Stimulus Effects with Δ9-Tetrahydrocannabinol in Mice
    Lenka Hruba, Alexandre Seillier, Armia Zaki, Benjamin F. Cravatt, Aron H. Lichtman, Andrea Giuffrida and Lance R. McMahon
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 261-268; DOI: https://doi.org/10.1124/jpet.115.222836
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    Evaluating an Etiologically Relevant Platform for Therapy Development for Temporal Lobe Epilepsy: Effects of Carbamazepine and Valproic Acid on Acute Seizures and Chronic Behavioral Comorbidities in the Theiler’s Murine Encephalomyelitis Virus Mouse Model
    Melissa L. Barker-Haliski, E. Jill Dahle, Taylor D. Heck, Timothy H. Pruess, Fabiola Vanegas, Karen S. Wilcox and H. Steve White
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 318-329; DOI: https://doi.org/10.1124/jpet.114.222513
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    Selective Monoacylglycerol Lipase Inhibitors: Antinociceptive versus Cannabimimetic Effects in Mice
    Bogna Ignatowska-Jankowska, Jenny L. Wilkerson, Mohammed Mustafa, Rehab Abdullah, Micah Niphakis, Jenny L. Wiley, Benjamin F. Cravatt and Aron H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 424-432; DOI: https://doi.org/10.1124/jpet.114.222315

Cardiovascular

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    The Novel Prostaglandin I2 Mimetic ONO-1301 Escapes Desensitization in an Antiplatelet Effect Due to Its Inhibitory Action on Thromboxane A2 Synthesis in Mice
    Hitoshi Kashiwagi, Koh-ichi Yuhki, Fumiaki Kojima, Shima Kumei, Osamu Takahata, Yoshiki Sakai, Shuh Narumiya and Fumitaka Ushikubi
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 269-278; DOI: https://doi.org/10.1124/jpet.115.222612

Drug Discovery and Translational Medicine

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    A Novel In Vivo Receptor Occupancy Methodology for the Glucocorticoid Receptor: Toward An Improved Understanding of Lung Pharmacokinetic/Pharmacodynamic Relationships
    Elin Boger, Pär Ewing, Ulf G. Eriksson, Britt-Marie Fihn, Michael Chappell, Neil Evans and Markus Fridén
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 279-287; DOI: https://doi.org/10.1124/jpet.114.221226
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    PF-1355, a Mechanism-Based Myeloperoxidase Inhibitor, Prevents Immune Complex Vasculitis and Anti–Glomerular Basement Membrane Glomerulonephritis
    Wei Zheng, Roscoe Warner, Roger Ruggeri, Chunyan Su, Christian Cortes, Athanasia Skoura, Jessica Ward, Kay Ahn, Amit Kalgutkar, Dexue Sun, Tristan S. Maurer, Paul D. Bonin, Carlin Okerberg, Walter Bobrowski, Thomas Kawabe, Yanwei Zhang, Timothy Coskran, Sammy Bell, Bhupesh Kapoor, Kent Johnson and Leonard Buckbinder
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 288-298; DOI: https://doi.org/10.1124/jpet.114.221788
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    Beneficial Effect of the Soluble Guanylyl Cyclase Stimulator BAY 41-2272 on Impaired Penile Erection in db/db−/− Type II Diabetic and Obese Mice
    Kenia Pedrosa Nunes, Cleber E. Teixeira, Fernanda B. M. Priviero, Haroldo A. Toque and R. Clinton Webb
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 330-339; DOI: https://doi.org/10.1124/jpet.114.220970
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    Pharmacological Characterization of AZD5069, a Slowly Reversible CXC Chemokine Receptor 2 Antagonist
    David J. Nicholls, Katherine Wiley, Ian Dainty, Fraser MacIntosh, Caroline Phillips, Alasdair Gaw and Carina Kärrman Mårdh
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 340-350; DOI: https://doi.org/10.1124/jpet.114.221358
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    A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer
    Anja Bastian, Jessica E. Thorpe, Bryan C. Disch, Lora C. Bailey-Downs, Aleem Gangjee, Ravi K. V. Devambatla, Jim Henthorn, Kenneth M. Humphries, Shraddha S. Vadvalkar and Michael A. Ihnat
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 392-404; DOI: https://doi.org/10.1124/jpet.114.220335
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    VX-509 (Decernotinib) Is a Potent and Selective Janus Kinase 3 Inhibitor That Attenuates Inflammation in Animal Models of Autoimmune Disease
    Sudipta Mahajan, James K. Hogan, Dina Shlyakhter, Luke Oh, Francesco G. Salituro, Luc Farmer and Thomas C. Hoock
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 405-414; DOI: https://doi.org/10.1124/jpet.114.221176
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    The Ellagic Acid Derivative 4,4′-Di-O-Methylellagic Acid Efficiently Inhibits Colon Cancer Cell Growth through a Mechanism Involving WNT16
    Ana Ramírez de Molina, Teodoro Vargas, Susana Molina, Jenifer Sánchez, Jorge Martínez-Romero, Margarita González-Vallinas, Roberto Martín-Hernández, Ruth Sánchez-Martínez, Marta Gómez de Cedrón, Alberto Dávalos, Luca Calani, Daniele Del Rio, Antonio González-Sarrías, Juan Carlos Espín, Francisco A. Tomás-Barberán and Guillermo Reglero
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 433-444; DOI: https://doi.org/10.1124/jpet.114.221796

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    In Vivo Visualization of the Antialbuminuric Effects of the Angiotensin-Converting Enzyme Inhibitor Enalapril
    Ina Maria Schießl, Veronika Kattler and Hayo Castrop
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 299-306; DOI: https://doi.org/10.1124/jpet.114.222125
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    Protective Role of Cannabinoid Receptor 2 Activation in Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure through Regulation of Macrophage Polarization and MicroRNAs
    Sunil Tomar, Elizabeth E. Zumbrun, Mitzi Nagarkatti and Prakash S. Nagarkatti
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 369-379; DOI: https://doi.org/10.1124/jpet.114.220368

Metabolism, Transport, and Pharmacogenomics

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    Pilocarpine-Induced Convulsive Activity Is Limited by Multidrug Transporters at the Rodent Blood-Brain Barrier
    K. Römermann, J. P. Bankstahl, W. Löscher and M. Bankstahl
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 351-359; DOI: https://doi.org/10.1124/jpet.114.221952
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    Evaluation of Rosuvastatin as an Organic Anion Transporting Polypeptide (OATP) Probe Substrate: In Vitro Transport and In Vivo Disposition in Cynomolgus Monkeys
    Hong Shen, Hong Su, Tongtong Liu, Ming Yao, Gabe Mintier, Lun Li, R. Marcus Fancher, Ramaswamy Iyer, Punit Marathe, Yurong Lai and A. David Rodrigues
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 380-391; DOI: https://doi.org/10.1124/jpet.114.221804
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    Species Differences in Hepatobiliary Disposition of Taurocholic Acid in Human and Rat Sandwich-Cultured Hepatocytes: Implications for Drug-Induced Liver Injury
    Kyunghee Yang, Nathan D. Pfeifer, Kathleen Köck and Kim L. R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 415-423; DOI: https://doi.org/10.1124/jpet.114.221564

Neuropharmacology

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    Characterization of a Pachymedusa dacnicolor–Sauvagine Analog as a New High-Affinity Radioligand for Corticotropin-Releasing Factor Receptor Studies
    Marilyn H. Perrin, Laura A. Tan, Joan M. Vaughan, Kathy A. Lewis, Cynthia J. Donaldson, Charleen Miller, Judit Erchegyi, Jean E. Rivier and Paul E. Sawchenko
    Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 307-317; DOI: https://doi.org/10.1124/jpet.114.222307
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 353 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 353, Issue 2
1 May 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Highlighted Papers
  • Minireviews
  • Behavioral Pharmacology
  • Cardiovascular
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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