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Research ArticleInflammation, Immunopharmacology, and Asthma

Ginsenoside Metabolite Compound K Suppresses T-Cell Priming via Modulation of Dendritic Cell Trafficking and Costimulatory Signals, Resulting in Alleviation of Collagen-Induced Arthritis

Jingyu Chen, Huaxun Wu, Qingtong Wang, Yan Chang, Kangkang Liu and Wei Wei
Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 71-79; DOI: https://doi.org/10.1124/jpet.114.220665
Jingyu Chen
Institute of Clinical Pharmacology of Anhui Medical University and Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China
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Huaxun Wu
Institute of Clinical Pharmacology of Anhui Medical University and Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China
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Qingtong Wang
Institute of Clinical Pharmacology of Anhui Medical University and Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China
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Yan Chang
Institute of Clinical Pharmacology of Anhui Medical University and Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China
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Kangkang Liu
Institute of Clinical Pharmacology of Anhui Medical University and Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China
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Wei Wei
Institute of Clinical Pharmacology of Anhui Medical University and Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China
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Abstract

Ginsenoside metabolite compound K (CK; 20-O-d-glucopyranosyl-20(S)-protopanaxadiol), a novel ginsenoside metabolite, belongs to the dammarane-type triterpene saponins, according to its structure. The anti-inflammatory activity of CK has been identified in several studies. Our study demonstrated that CK exerted an anti-inflammatory effect in collagen-induced arthritis (CIA) and adjuvant-induced arthritis animal models, and this effect was due to inhibition of the abnormal activation and differentiation of T cells. However, the mechanism of CK in suppressing T-cell activation remains unclear. In this study, CK had a therapeutic effect in mice with CIA, decreased the percentage of activated T cells and dendritic cells (DCs), and increased the percentage of naive T cells in lymph nodes. The inhibitory effect on T-cell activation of CK was related to suppression of accumulation of DCs in lymph nodes. CK decreased CCL21 levels in lymph nodes and CCR7 expression in DCs and suppressed CCL21/CCR7-mediated migration of DCs, thus reducing accumulation of DCs in lymph nodes. In addition, signals for T-cell activation including major histocompatibility complex class II and costimulatory molecules, such as CD80 and CD86, were suppressed by CK, and the proliferation of T cells induced by DCs was inhibited by CK. In conclusion, this study demonstrated that CK downregulated DC priming of T-cell activation in CIA, and suppression of CCL21/CCR7-mediated DC migration and signaling between T cells and DCs might be the potential mechanism. These results provide an interesting, novel insight into the potential mechanism by which CK contributes to the anti-inflammatory effect in autoimmune conditions.

Footnotes

    • Received October 15, 2014.
    • Accepted January 26, 2015.
  • This work was supported by the National Nature Science Foundation of China [Grants 81330081, 31200675, and 81173075]; Anhui Province Nature Science Foundation in the University [Grant KJ2011Z180]; Foundation for Outstanding Young Talents in Higher Education Institutions of Anhui Province [Grant 2012SQRL268]; and Anhui Provincial Natural Science Foundation [Grant 1208085QH158].

  • dx.doi.org/10.1124/jpet.114.220665.

  • Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 353 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 353, Issue 1
1 Apr 2015
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Research ArticleInflammation, Immunopharmacology, and Asthma

CK Suppresses T-Cell Priming by Modulation of DCs

Jingyu Chen, Huaxun Wu, Qingtong Wang, Yan Chang, Kangkang Liu and Wei Wei
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 71-79; DOI: https://doi.org/10.1124/jpet.114.220665

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Research ArticleInflammation, Immunopharmacology, and Asthma

CK Suppresses T-Cell Priming by Modulation of DCs

Jingyu Chen, Huaxun Wu, Qingtong Wang, Yan Chang, Kangkang Liu and Wei Wei
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 71-79; DOI: https://doi.org/10.1124/jpet.114.220665
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