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Research ArticleDrug Discovery and Translational Medicine

2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm Ischemia-Reperfusion Injury of Rat Liver

Boleslav Kosharskyy, Amaresh Vydyanathan, Lihai Zhang, Naum Shaparin, Brian C. Geohagen, William Bivin, Qiang Liu, Terrence Gavin and Richard M. LoPachin
Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 150-158; DOI: https://doi.org/10.1124/jpet.114.221622
Boleslav Kosharskyy
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Amaresh Vydyanathan
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Lihai Zhang
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Naum Shaparin
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Brian C. Geohagen
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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William Bivin
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Qiang Liu
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Terrence Gavin
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Richard M. LoPachin
Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
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Article Information

vol. 353 no. 1 150-158
DOI 
https://doi.org/10.1124/jpet.114.221622
PubMed 
25659651

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 24, 2014
  • Accepted February 5, 2015
  • Published online February 27, 2015.

Article Versions

  • Earlier version (February 6, 2015 - 12:56).
  • Earlier version (February 23, 2015 - 12:33).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Boleslav Kosharskyy,
  2. Amaresh Vydyanathan,
  3. Lihai Zhang,
  4. Naum Shaparin,
  5. Brian C. Geohagen,
  6. William Bivin,
  7. Qiang Liu,
  8. Terrence Gavin, and
  9. Richard M. LoPachin
  1. Departments of Anesthesiology (B.K., A.V., L.Z., N.S., B.C.G., R.M.L.) and Pathology (W.B., Q.L.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Iona College, New Rochelle, New York (T.G.)
  1. Address correspondence to:
    Dr. Richard M. LoPachin, Department of Anesthesiology, Montefiore Medical School, 111 E. 210th Street, Bronx, NY 10467. E-mail: lopachin{at}einstein.yu.edu
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Journal of Pharmacology and Experimental Therapeutics: 353 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 353, Issue 1
1 Apr 2015
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Research ArticleDrug Discovery and Translational Medicine

Enolate Hepatoprotection in Ischemia-Reperfusion

Boleslav Kosharskyy, Amaresh Vydyanathan, Lihai Zhang, Naum Shaparin, Brian C. Geohagen, William Bivin, Qiang Liu, Terrence Gavin and Richard M. LoPachin
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 150-158; DOI: https://doi.org/10.1124/jpet.114.221622

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Research ArticleDrug Discovery and Translational Medicine

Enolate Hepatoprotection in Ischemia-Reperfusion

Boleslav Kosharskyy, Amaresh Vydyanathan, Lihai Zhang, Naum Shaparin, Brian C. Geohagen, William Bivin, Qiang Liu, Terrence Gavin and Richard M. LoPachin
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 150-158; DOI: https://doi.org/10.1124/jpet.114.221622
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