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Research ArticleBehavioral Pharmacology

Interactions between Bupropion and 3,4-Methylenedioxymethamphetamine in Healthy Subjects

Yasmin Schmid, Anna Rickli, Antonia Schaffner, Urs Duthaler, Eric Grouzmann, Cédric M. Hysek and Matthias E. Liechti
Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 102-111; DOI: https://doi.org/10.1124/jpet.114.222356
Yasmin Schmid
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Anna Rickli
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Antonia Schaffner
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Urs Duthaler
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Eric Grouzmann
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Cédric M. Hysek
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Matthias E. Liechti
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.)
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Abstract

3,4-Methylenedioxymethamphetamine (MDMA; “ecstasy”) is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine and norepinephrine. The pharmacodynamic and pharmacokinetic interactions between bupropion and MDMA in 16 healthy subjects were investigated using a double-blind, placebo-controlled, crossover design. Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations. These results indicate a role for the transporter-mediated release of norepinephrine in the cardiostimulant effects of MDMA but do not support a modulatory role for dopamine in the mood effects of MDMA. These results also indicate that the use of MDMA during therapy with bupropion may result in higher plasma concentrations of both MDMA and bupropion and enhanced mood effects but also result in lower cardiac stimulation.

Footnotes

    • Received December 22, 2014.
    • Accepted February 4, 2015.
  • Y.S. and A.R. contributed equally to this work.

  • This study was supported by the Swiss National Science Foundation (320030_149493).

  • dx.doi.org/10.1124/jpet.114.222356.

  • Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 353 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 353, Issue 1
1 Apr 2015
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Research ArticleBehavioral Pharmacology

Bupropion and MDMA

Yasmin Schmid, Anna Rickli, Antonia Schaffner, Urs Duthaler, Eric Grouzmann, Cédric M. Hysek and Matthias E. Liechti
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 102-111; DOI: https://doi.org/10.1124/jpet.114.222356

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Research ArticleBehavioral Pharmacology

Bupropion and MDMA

Yasmin Schmid, Anna Rickli, Antonia Schaffner, Urs Duthaler, Eric Grouzmann, Cédric M. Hysek and Matthias E. Liechti
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 102-111; DOI: https://doi.org/10.1124/jpet.114.222356
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