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Research ArticleMetabolism, Transport, and Pharmacogenomics

Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis

Anika L. Dzierlenga, John D. Clarke, Tiffanie L. Hargraves, Garrett R. Ainslie, Todd W. Vanderah, Mary F. Paine and Nathan J. Cherrington
Journal of Pharmacology and Experimental Therapeutics March 2015, 352 (3) 462-470; DOI: https://doi.org/10.1124/jpet.114.220764
Anika L. Dzierlenga
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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John D. Clarke
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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Tiffanie L. Hargraves
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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Garrett R. Ainslie
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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Todd W. Vanderah
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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Mary F. Paine
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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Nathan J. Cherrington
Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
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Article Information

vol. 352 no. 3 462-470
DOI 
https://doi.org/10.1124/jpet.114.220764
PubMed 
25512370

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 15, 2014
  • Accepted December 12, 2014
  • Published online January 19, 2015.

Article Versions

  • Earlier version (December 15, 2014 - 08:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anika L. Dzierlenga,
  2. John D. Clarke,
  3. Tiffanie L. Hargraves,
  4. Garrett R. Ainslie,
  5. Todd W. Vanderah,
  6. Mary F. Paine, and
  7. Nathan J. Cherrington
  1. Departments of Pharmacology and Toxicology (A.L.D., J.D.C., T.L.H., N.J.C.) and Pharmacology (T.W.V.), University of Arizona, Tucson, Arizona; Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina (G.R.A., M.F.P.); and Section of Experimental and Systems Pharmacology, Washington State University, Spokane, Washington (G.R.A., M.F.P.)
  1. Address correspondence to:
    Nathan J. Cherrington, Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, Tucson, AZ 85721. E-mail: cherrington{at}pharmacy.arizona.edu
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Journal of Pharmacology and Experimental Therapeutics: 352 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 352, Issue 3
1 Mar 2015
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Morphine Disposition in Nonalcoholic Steatohepatitis

Anika L. Dzierlenga, John D. Clarke, Tiffanie L. Hargraves, Garrett R. Ainslie, Todd W. Vanderah, Mary F. Paine and Nathan J. Cherrington
Journal of Pharmacology and Experimental Therapeutics March 1, 2015, 352 (3) 462-470; DOI: https://doi.org/10.1124/jpet.114.220764

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Morphine Disposition in Nonalcoholic Steatohepatitis

Anika L. Dzierlenga, John D. Clarke, Tiffanie L. Hargraves, Garrett R. Ainslie, Todd W. Vanderah, Mary F. Paine and Nathan J. Cherrington
Journal of Pharmacology and Experimental Therapeutics March 1, 2015, 352 (3) 462-470; DOI: https://doi.org/10.1124/jpet.114.220764
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