Research ArticleMetabolism, Transport, and Pharmacogenomics
A UGT2B10 Splicing Polymorphism Common in African Populations May Greatly Increase Drug Exposure
Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss and Victor A. Iglesias
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 358-367; DOI: https://doi.org/10.1124/jpet.114.220194
Stephen Fowler
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Heidemarie Kletzl
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Moshe Finel
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Nenad Manevski
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Paul Schmid
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Dietrich Tuerck
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Roger D. Norcross
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Marius C. Hoener
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Olivia Spleiss
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Victor A. Iglesias
Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleMetabolism, Transport, and Pharmacogenomics
UGT2B10 Splice Variant Increases Drug Exposure in Africans
Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss and Victor A. Iglesias
Journal of Pharmacology and Experimental Therapeutics February 1, 2015, 352 (2) 358-367; DOI: https://doi.org/10.1124/jpet.114.220194
Research ArticleMetabolism, Transport, and Pharmacogenomics
UGT2B10 Splice Variant Increases Drug Exposure in Africans
Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss and Victor A. Iglesias
Journal of Pharmacology and Experimental Therapeutics February 1, 2015, 352 (2) 358-367; DOI: https://doi.org/10.1124/jpet.114.220194
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement