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Research ArticleMetabolism, Transport, and Pharmacogenomics

A UGT2B10 Splicing Polymorphism Common in African Populations May Greatly Increase Drug Exposure

Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss and Victor A. Iglesias
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 358-367; DOI: https://doi.org/10.1124/jpet.114.220194

Article Information

vol. 352 no. 2 358-367
DOI 
https://doi.org/10.1124/jpet.114.220194
PubMed 
25503386
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 26, 2014
  • Accepted December 10, 2014
  • Published online January 6, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephen Fowler,
  2. Heidemarie Kletzl,
  3. Moshe Finel,
  4. Nenad Manevski1,
  5. Paul Schmid,
  6. Dietrich Tuerck,
  7. Roger D. Norcross,
  8. Marius C. Hoener,
  9. Olivia Spleiss, and
  10. Victor A. Iglesias
  1. Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)
  1. Address correspondence to:
    Victor A. Iglesias, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel CH-4070, Switzerland. E-mail: victor_alejandro.iglesias{at}roche.com
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Research ArticleMetabolism, Transport, and Pharmacogenomics

UGT2B10 Splice Variant Increases Drug Exposure in Africans

Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss and Victor A. Iglesias
Journal of Pharmacology and Experimental Therapeutics February 1, 2015, 352 (2) 358-367; DOI: https://doi.org/10.1124/jpet.114.220194
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