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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

M1 Polarization Bias and Subsequent Nonalcoholic Steatohepatitis Progression Is Attenuated by Nitric Oxide Donor DETA NONOate via Inhibition of CYP2E1-Induced Oxidative Stress in Obese Mice

Ratanesh Kumar Seth, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A. Michelotti, Anna Mae Diehl and Saurabh Chatterjee
Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 77-89; DOI: https://doi.org/10.1124/jpet.114.218131
Ratanesh Kumar Seth
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Suvarthi Das
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Sahar Pourhoseini
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Diptadip Dattaroy
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Stephen Igwe
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Julie Basu Ray
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Daping Fan
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Gregory A. Michelotti
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Anna Mae Diehl
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Saurabh Chatterjee
Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
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Article Information

vol. 352 no. 1 77-89
DOI 
https://doi.org/10.1124/jpet.114.218131
PubMed 
25347994

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 14, 2014
  • Accepted October 23, 2014
  • Published online November 18, 2014.

Article Versions

  • Earlier version (October 27, 2014 - 12:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ratanesh Kumar Seth,
  2. Suvarthi Das,
  3. Sahar Pourhoseini,
  4. Diptadip Dattaroy,
  5. Stephen Igwe,
  6. Julie Basu Ray,
  7. Daping Fan,
  8. Gregory A. Michelotti,
  9. Anna Mae Diehl, and
  10. Saurabh Chatterjee
  1. Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina (R.K.S., S.D., S.P., D.D., S.C.); School of Science, Technology, Engineering and Mathematics (STEM), Dillard University, New Orleans, Louisiana (S.I., J.B.R.); Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina (D.F.); and Division of Gastroenterology, Duke University, Durham, North Carolina (G.A.M., A.M.D.)
  1. Address correspondence to:
    Dr. Saurabh Chatterjee, Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208. E-mail: schatt{at}mailbox.sc.edu
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Journal of Pharmacology and Experimental Therapeutics: 352 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 352, Issue 1
1 Jan 2015
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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

NO Donor Attenuates Inflammation in NASH Liver

Ratanesh Kumar Seth, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A. Michelotti, Anna Mae Diehl and Saurabh Chatterjee
Journal of Pharmacology and Experimental Therapeutics January 1, 2015, 352 (1) 77-89; DOI: https://doi.org/10.1124/jpet.114.218131

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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

NO Donor Attenuates Inflammation in NASH Liver

Ratanesh Kumar Seth, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A. Michelotti, Anna Mae Diehl and Saurabh Chatterjee
Journal of Pharmacology and Experimental Therapeutics January 1, 2015, 352 (1) 77-89; DOI: https://doi.org/10.1124/jpet.114.218131
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