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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2015; Volume 352,Issue 1

Highlighted Papers

  • You have access
    N-Methyl-d-Aspartate Channel Blocker–Like Discriminative Stimulus Effects of Nitrous Oxide Gas
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HI
  • You have access
    Antidepressants and Antipsychotics That Inhibit AaDOP2 as Potential Insecticides
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HIa
  • You have access
    Analgesic Properties of a GalR2–Receptor Preferring Galanin Analog
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HIb
  • You have access
    Disposition of Methylthioninium Redox Forms Determines Efficacy in Alzheimer’s Disease
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HIc

Minireview

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    Epigenetic Modifications in Fibrotic Diseases: Implications for Pathogenesis and Pharmacological Targets
    Hong-Wei Yao and Jun Li
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 2-13; DOI: https://doi.org/10.1124/jpet.114.219816

Behavioral Pharmacology

  • You have access
    N-Methyl-d-Aspartate Receptor Channel Blocker–Like Discriminative Stimulus Effects of Nitrous Oxide Gas
    Kellianne J. Richardson and Keith L. Shelton
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 156-165; DOI: https://doi.org/10.1124/jpet.114.218057

Cardiovascular

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    Vanillin and Vanillin Analogs Relax Porcine Coronary and Basilar Arteries by Inhibiting L-Type Ca2+ Channels
    Gábor Raffai, Gilson Khang and Paul M. Vanhoutte
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 14-22; DOI: https://doi.org/10.1124/jpet.114.217935
  • You have access
    Ophiopogonin D Attenuates Doxorubicin-Induced Autophagic Cell Death by Relieving Mitochondrial Damage In Vitro and In Vivo
    Ying-Yu Zhang, Chen Meng, Xin-Mu Zhang, Cai-Hua Yuan, Ming-Da Wen, Zhong Chen, Da-Chuan Dong, Yan-Hong Gao, Chang Liu and Zhao Zhang
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 166-174; DOI: https://doi.org/10.1124/jpet.114.219261

Cellular and Molecular

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    Brazilin Isolated from Caesalpinia sappan Suppresses Nuclear Envelope Reassembly by Inhibiting Barrier-to-Autointegration Factor Phosphorylation
    Seong-Hoon Kim, Ha-Na Lyu, Ye Seul Kim, Yong Hyun Jeon, Wanil Kim, Sangjune Kim, Jong-Kwan Lim, Ho Won Lee, Nam-In Baek, Kwan-Yong Choi, Jaetae Lee and Kyong-Tai Kim
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 175-184; DOI: https://doi.org/10.1124/jpet.114.218792

Chemotherapy, Antibiotics, and Gene Therapy

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    Regulation of a Notch3-Hes1 Pathway and Protective Effect by a Tocopherol-Omega Alkanol Chain Derivative in Muscle Atrophy
    Yannick von Grabowiecki, Cynthia Licona, Lavinia Palamiuc, Paula Abreu, Vania Vidimar, Djalil Coowar, Georg Mellitzer and Christian Gaiddon
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 23-32; DOI: https://doi.org/10.1124/jpet.114.216879

Drug Discovery and Translational Medicine

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    An α-Acetoxy-Tirucallic Acid Isomer Inhibits Akt/mTOR Signaling and Induces Oxidative Stress in Prostate Cancer Cells
    Menna El Gaafary, Berthold Büchele, Tatiana Syrovets, Sara Agnolet, Bernd Schneider, Christoph Q. Schmidt and Thomas Simmet
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 33-42; DOI: https://doi.org/10.1124/jpet.114.217323
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    Seizure Control by Derivatives of Medium Chain Fatty Acids Associated with the Ketogenic Diet Show Novel Branching-Point Structure for Enhanced Potency
    Pishan Chang, Alexandra M. E. Zuckermann, Sophie Williams, Adam J. Close, Marife Cano-Jaimez, James P. McEvoy, John Spencer, Matthew C. Walker and Robin S. B. Williams
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 43-52; DOI: https://doi.org/10.1124/jpet.114.218768
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    Evaluation of AaDOP2 Receptor Antagonists Reveals Antidepressants and Antipsychotics as Novel Lead Molecules for Control of the Yellow Fever Mosquito, Aedes aegypti
    Jason M. Conley, Jason M. Meyer, Andrew B. Nuss, Trevor B. Doyle, Sergey N. Savinov, Catherine A. Hill and Val J. Watts
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 53-60; DOI: https://doi.org/10.1124/jpet.114.219717
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    Pharmacologic Targeting of Sphingosine-1-Phosphate Receptor 1 Improves the Renal Microcirculation during Sepsis in the Mouse
    Zhen Wang, Clark R. Sims, Naeem K. Patil, Neriman Gokden and Philip R. Mayeux
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 61-66; DOI: https://doi.org/10.1124/jpet.114.219394
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    The Antiparasitic Drug, Potassium Antimony Tartrate, Inhibits Tumor Angiogenesis and Tumor Growth in Nonsmall-Cell Lung Cancer
    Beibei Wang, Weiwei Yu, Jiawei Guo, Xingwu Jiang, Weiqiang Lu, Mingyao Liu and Xiufeng Pang
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 129-138; DOI: https://doi.org/10.1124/jpet.114.218644
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    Analgesic Properties of a Peripherally Acting and GalR2 Receptor–Preferring Galanin Analog in Inflammatory, Neuropathic, and Acute Pain Models
    Cameron S. Metcalf, Brian D. Klein, Daniel R. McDougle, Liuyin Zhang, Misty D. Smith, Grzegorz Bulaj and H. Steve White
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 185-193; DOI: https://doi.org/10.1124/jpet.114.219063

Endocrine and Diabetes

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    Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 by Adrenal Corticosteroids and Product-Feedback by Androstenedione in Human Adrenarche
    James L. Thomas, Maheshinie Rajapaksha, Vance L. Mack, Geneva A. DeMars, Joseph A. Majzoub and Himangshu S. Bose
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 67-76; DOI: https://doi.org/10.1124/jpet.114.219550

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    M1 Polarization Bias and Subsequent Nonalcoholic Steatohepatitis Progression Is Attenuated by Nitric Oxide Donor DETA NONOate via Inhibition of CYP2E1-Induced Oxidative Stress in Obese Mice
    Ratanesh Kumar Seth, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A. Michelotti, Anna Mae Diehl and Saurabh Chatterjee
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 77-89; DOI: https://doi.org/10.1124/jpet.114.218131
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    Demethyleneberberine, a Natural Mitochondria-Targeted Antioxidant, Inhibits Mitochondrial Dysfunction, Oxidative Stress, and Steatosis in Alcoholic Liver Disease Mouse Model
    Pengcheng Zhang, Xiaoyan Qiang, Miao Zhang, Dongshen Ma, Zheng Zhao, Cuisong Zhou, Xie Liu, Ruiyan Li, Huan Chen and Yubin Zhang
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 139-147; DOI: https://doi.org/10.1124/jpet.114.219832

Inflammation, Immunopharmacology, and Asthma

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    The Antipsoriatic Agent Monomethylfumarate Has Antiproliferative, Prodifferentiative, and Anti-Inflammatory Effects on Keratinocytes
    Inas Helwa, Ravi Patel, Peter Karempelis, Ismail Kaddour-Djebbar, Vivek Choudhary and Wendy B. Bollag
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 90-97; DOI: https://doi.org/10.1124/jpet.114.218818

Neuropharmacology

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    The G Protein–Biased κ-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo
    Kate L. White, J. Elliott Robinson, Hu Zhu, Jeffrey F. DiBerto, Prabhakar R. Polepally, Jordan K. Zjawiony, David E. Nichols, C. J. Malanga and Bryan L. Roth
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 98-109; DOI: https://doi.org/10.1124/jpet.114.216820
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    Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer’s Disease
    Thomas C. Baddeley, Jennifer McCaffrey, John M. D. Storey, John K. S. Cheung, Valeria Melis, David Horsley, Charles R. Harrington and Claude M. Wischik
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 110-118; DOI: https://doi.org/10.1124/jpet.114.219352
  • You have access
    Melatonin Receptors Trigger cAMP Production and Inhibit Chloride Movements in Nonpigmented Ciliary Epithelial Cells
    Fernando Huete-Toral, Almudena Crooke, Alejandro Martínez-Águila and Jesús Pintor
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 119-128; DOI: https://doi.org/10.1124/jpet.114.218263
  • You have access
    Evidence for α-Helices in the Large Intracellular Domain Mediating Modulation of the α1-Glycine Receptor by Ethanol and Gβγ
    Carlos F. Burgos, Patricio A. Castro, Trinidad Mariqueo, Marta Bunster, Leonardo Guzmán and Luis G. Aguayo
    Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 148-155; DOI: https://doi.org/10.1124/jpet.114.217976
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 352 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 352, Issue 1
1 Jan 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Highlighted Papers
  • Minireview
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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