Journal of Pharmacology and Experimental Therapeutics: 352 (1)

January 01, 2015; Volume 352,Issue 1

Highlighted Papers

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N-Methyl-d-Aspartate Channel Blocker–Like Discriminative Stimulus Effects of Nitrous Oxide Gas
Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HI
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Antidepressants and Antipsychotics That Inhibit AaDOP2 as Potential Insecticides
Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HIa
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Analgesic Properties of a GalR2–Receptor Preferring Galanin Analog
Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HIb
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Disposition of Methylthioninium Redox Forms Determines Efficacy in Alzheimer’s Disease
Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 1; DOI: https://doi.org/10.1124/jpet.115.0115HIc

Minireview

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Epigenetic Modifications in Fibrotic Diseases: Implications for Pathogenesis and Pharmacological Targets
Hong-Wei Yao and Jun Li

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 2-13; DOI: https://doi.org/10.1124/jpet.114.219816

Behavioral Pharmacology

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N-Methyl-d-Aspartate Receptor Channel Blocker–Like Discriminative Stimulus Effects of Nitrous Oxide Gas
Kellianne J. Richardson and Keith L. Shelton

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 156-165; DOI: https://doi.org/10.1124/jpet.114.218057

Cardiovascular

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Vanillin and Vanillin Analogs Relax Porcine Coronary and Basilar Arteries by Inhibiting L-Type Ca²⁺ Channels
Gábor Raffai, Gilson Khang and Paul M. Vanhoutte

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 14-22; DOI: https://doi.org/10.1124/jpet.114.217935
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Ophiopogonin D Attenuates Doxorubicin-Induced Autophagic Cell Death by Relieving Mitochondrial Damage In Vitro and In Vivo
Ying-Yu Zhang, Chen Meng, Xin-Mu Zhang, Cai-Hua Yuan, Ming-Da Wen, Zhong Chen, Da-Chuan Dong, Yan-Hong Gao, Chang Liu and Zhao Zhang

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 166-174; DOI: https://doi.org/10.1124/jpet.114.219261

Cellular and Molecular

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Brazilin Isolated from Caesalpinia sappan Suppresses Nuclear Envelope Reassembly by Inhibiting Barrier-to-Autointegration Factor Phosphorylation
Seong-Hoon Kim, Ha-Na Lyu, Ye Seul Kim, Yong Hyun Jeon, Wanil Kim, Sangjune Kim, Jong-Kwan Lim, Ho Won Lee, Nam-In Baek, Kwan-Yong Choi, Jaetae Lee and Kyong-Tai Kim

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 175-184; DOI: https://doi.org/10.1124/jpet.114.218792

Chemotherapy, Antibiotics, and Gene Therapy

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Regulation of a Notch3-Hes1 Pathway and Protective Effect by a Tocopherol-Omega Alkanol Chain Derivative in Muscle Atrophy
Yannick von Grabowiecki, Cynthia Licona, Lavinia Palamiuc, Paula Abreu, Vania Vidimar, Djalil Coowar, Georg Mellitzer and Christian Gaiddon

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 23-32; DOI: https://doi.org/10.1124/jpet.114.216879

Drug Discovery and Translational Medicine

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An α-Acetoxy-Tirucallic Acid Isomer Inhibits Akt/mTOR Signaling and Induces Oxidative Stress in Prostate Cancer Cells
Menna El Gaafary, Berthold Büchele, Tatiana Syrovets, Sara Agnolet, Bernd Schneider, Christoph Q. Schmidt and Thomas Simmet

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 33-42; DOI: https://doi.org/10.1124/jpet.114.217323
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Seizure Control by Derivatives of Medium Chain Fatty Acids Associated with the Ketogenic Diet Show Novel Branching-Point Structure for Enhanced Potency
Pishan Chang, Alexandra M. E. Zuckermann, Sophie Williams, Adam J. Close, Marife Cano-Jaimez, James P. McEvoy, John Spencer, Matthew C. Walker and Robin S. B. Williams

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 43-52; DOI: https://doi.org/10.1124/jpet.114.218768
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Evaluation of AaDOP2 Receptor Antagonists Reveals Antidepressants and Antipsychotics as Novel Lead Molecules for Control of the Yellow Fever Mosquito, Aedes aegypti
Jason M. Conley, Jason M. Meyer, Andrew B. Nuss, Trevor B. Doyle, Sergey N. Savinov, Catherine A. Hill and Val J. Watts

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 53-60; DOI: https://doi.org/10.1124/jpet.114.219717
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Pharmacologic Targeting of Sphingosine-1-Phosphate Receptor 1 Improves the Renal Microcirculation during Sepsis in the Mouse
Zhen Wang, Clark R. Sims, Naeem K. Patil, Neriman Gokden and Philip R. Mayeux

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 61-66; DOI: https://doi.org/10.1124/jpet.114.219394
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The Antiparasitic Drug, Potassium Antimony Tartrate, Inhibits Tumor Angiogenesis and Tumor Growth in Nonsmall-Cell Lung Cancer
Beibei Wang, Weiwei Yu, Jiawei Guo, Xingwu Jiang, Weiqiang Lu, Mingyao Liu and Xiufeng Pang

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 129-138; DOI: https://doi.org/10.1124/jpet.114.218644
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Analgesic Properties of a Peripherally Acting and GalR2 Receptor–Preferring Galanin Analog in Inflammatory, Neuropathic, and Acute Pain Models
Cameron S. Metcalf, Brian D. Klein, Daniel R. McDougle, Liuyin Zhang, Misty D. Smith, Grzegorz Bulaj and H. Steve White

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 185-193; DOI: https://doi.org/10.1124/jpet.114.219063

Endocrine and Diabetes

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Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 by Adrenal Corticosteroids and Product-Feedback by Androstenedione in Human Adrenarche
James L. Thomas, Maheshinie Rajapaksha, Vance L. Mack, Geneva A. DeMars, Joseph A. Majzoub and Himangshu S. Bose

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 67-76; DOI: https://doi.org/10.1124/jpet.114.219550

Gastrointestinal, Hepatic, Pulmonary, and Renal

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M1 Polarization Bias and Subsequent Nonalcoholic Steatohepatitis Progression Is Attenuated by Nitric Oxide Donor DETA NONOate via Inhibition of CYP2E1-Induced Oxidative Stress in Obese Mice
Ratanesh Kumar Seth, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A. Michelotti, Anna Mae Diehl and Saurabh Chatterjee

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 77-89; DOI: https://doi.org/10.1124/jpet.114.218131
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Demethyleneberberine, a Natural Mitochondria-Targeted Antioxidant, Inhibits Mitochondrial Dysfunction, Oxidative Stress, and Steatosis in Alcoholic Liver Disease Mouse Model
Pengcheng Zhang, Xiaoyan Qiang, Miao Zhang, Dongshen Ma, Zheng Zhao, Cuisong Zhou, Xie Liu, Ruiyan Li, Huan Chen and Yubin Zhang

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 139-147; DOI: https://doi.org/10.1124/jpet.114.219832

Inflammation, Immunopharmacology, and Asthma

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The Antipsoriatic Agent Monomethylfumarate Has Antiproliferative, Prodifferentiative, and Anti-Inflammatory Effects on Keratinocytes
Inas Helwa, Ravi Patel, Peter Karempelis, Ismail Kaddour-Djebbar, Vivek Choudhary and Wendy B. Bollag

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 90-97; DOI: https://doi.org/10.1124/jpet.114.218818

Neuropharmacology

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The G Protein–Biased κ-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo
Kate L. White, J. Elliott Robinson, Hu Zhu, Jeffrey F. DiBerto, Prabhakar R. Polepally, Jordan K. Zjawiony, David E. Nichols, C. J. Malanga and Bryan L. Roth

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 98-109; DOI: https://doi.org/10.1124/jpet.114.216820
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Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer’s Disease
Thomas C. Baddeley, Jennifer McCaffrey, John M. D. Storey, John K. S. Cheung, Valeria Melis, David Horsley, Charles R. Harrington and Claude M. Wischik

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 110-118; DOI: https://doi.org/10.1124/jpet.114.219352
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Melatonin Receptors Trigger cAMP Production and Inhibit Chloride Movements in Nonpigmented Ciliary Epithelial Cells
Fernando Huete-Toral, Almudena Crooke, Alejandro Martínez-Águila and Jesús Pintor

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 119-128; DOI: https://doi.org/10.1124/jpet.114.218263
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Evidence for α-Helices in the Large Intracellular Domain Mediating Modulation of the α1-Glycine Receptor by Ethanol and Gβγ
Carlos F. Burgos, Patricio A. Castro, Trinidad Mariqueo, Marta Bunster, Leonardo Guzmán and Luis G. Aguayo

Journal of Pharmacology and Experimental Therapeutics January 2015, 352 (1) 148-155; DOI: https://doi.org/10.1124/jpet.114.217976

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Table of Contents

Highlighted Papers

Minireview

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Neuropharmacology

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