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Research ArticleNeuropharmacology

The Human Ether-A-Go-Go–Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels

Ping Li, Xueqin Chen, Qiansen Zhang, Yueming Zheng, Hualiang Jiang, Huaiyu Yang and Zhaobing Gao
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 596-604; DOI: https://doi.org/10.1124/jpet.114.217703
Ping Li
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Xueqin Chen
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Qiansen Zhang
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Yueming Zheng
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Hualiang Jiang
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Huaiyu Yang
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Zhaobing Gao
CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Article Information

vol. 351 no. 3 596-604
DOI 
https://doi.org/10.1124/jpet.114.217703
PubMed 
25232191

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received June 18, 2014
  • Accepted September 16, 2014
  • Published online October 23, 2014.

Article Versions

  • Earlier version (September 17, 2014 - 11:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ping Li,
  2. Xueqin Chen,
  3. Qiansen Zhang,
  4. Yueming Zheng,
  5. Hualiang Jiang,
  6. Huaiyu Yang, and
  7. Zhaobing Gao
  1. CAS Key Laboratory of Receptor Research (P.L., X.C., Y.Z., Z.G.), and State Key Laboratory of Drug Research (Q.Z., H.J., H.Y.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
  1. Address correspondence to:
    Dr. Zhaobing Gao, Professor of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. E-mail: zbgao{at}simm.ac.cn; or Dr. Huaiyu Yang, Associate Professor of Computational Biology, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. E-mail: hyyang{at}simm.ac.cn
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Journal of Pharmacology and Experimental Therapeutics: 351 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 351, Issue 3
1 Dec 2014
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Research ArticleNeuropharmacology

NS1643 Rescues Both LQT2 and Epileptic Phenotypes

Ping Li, Xueqin Chen, Qiansen Zhang, Yueming Zheng, Hualiang Jiang, Huaiyu Yang and Zhaobing Gao
Journal of Pharmacology and Experimental Therapeutics December 1, 2014, 351 (3) 596-604; DOI: https://doi.org/10.1124/jpet.114.217703

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Research ArticleNeuropharmacology

NS1643 Rescues Both LQT2 and Epileptic Phenotypes

Ping Li, Xueqin Chen, Qiansen Zhang, Yueming Zheng, Hualiang Jiang, Huaiyu Yang and Zhaobing Gao
Journal of Pharmacology and Experimental Therapeutics December 1, 2014, 351 (3) 596-604; DOI: https://doi.org/10.1124/jpet.114.217703
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