Journal of Pharmacology and Experimental Therapeutics: 351 (3)

December 01, 2014; Volume 351,Issue 3

Highlighted Papers

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Tolerance to Hallucinogen-Induced Head Twitches in Mice
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 484; DOI: https://doi.org/10.1124/jpet.114.1214HI
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CYP1A1 and Cardiovascular Benefits of Omega-3 Polyunsaturated Fatty Acids
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 484; DOI: https://doi.org/10.1124/jpet.114.1214HIa
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The Role of Intestinal Human Pregnane X Receptor in Colon Cancer
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 484; DOI: https://doi.org/10.1124/jpet.114.1214HIb
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Acute Effects of Brexpiprazole on Serotonin, Dopamine, and Norepinephrine Systems
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 484; DOI: https://doi.org/10.1124/jpet.114.1214HIc

Behavioral Pharmacology

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Tolerance and Cross-Tolerance to Head Twitch Behavior Elicited by Phenethylamine- and Tryptamine-Derived Hallucinogens in Mice
Douglas A. Smith, Jessica M. Bailey, Diarria Williams and William E. Fantegrossi

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 485-491; DOI: https://doi.org/10.1124/jpet.114.219337

Cardiovascular

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Early and Transient Sodium-Hydrogen Exchanger Isoform 1 Inhibition Attenuates Subsequent Cardiac Hypertrophy and Heart Failure Following Coronary Artery Ligation
Ana Kilić, Cathy X. Huang, Venkatesh Rajapurohitam, Jeffrey B. Madwed and Morris Karmazyn

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 492-499; DOI: https://doi.org/10.1124/jpet.114.217091
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Protective Effects of Novel Metal-Nonoates on the Cellular Components of the Vascular System
Martina Monti, Raffaella Solito, Luca Puccetti, Luca Pasotti, Riccardo Roggeri, Enrico Monzani, Luigi Casella and Lucia Morbidelli

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 500-509; DOI: https://doi.org/10.1124/jpet.114.218404
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Role of CYP1A1 in Modulating the Vascular and Blood Pressure Benefits of Omega-3 Polyunsaturated Fatty Acids
Larry N. Agbor, Elani F. Wiest, Michael Rothe, Wolf-Hagen Schunck and Mary K. Walker

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 688-698; DOI: https://doi.org/10.1124/jpet.114.219535

Cellular and Molecular

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Downregulation of Ca²⁺-Activated Cl⁻ Channel TMEM16A by the Inhibition of Histone Deacetylase in TMEM16A-Expressing Cancer Cells
Sayo Matsuba, Satomi Niwa, Katsuhiko Muraki, Saki Kanatsuka, Yurika Nakazono, Noriyuki Hatano, Masanori Fujii, Peng Zhan, Takayoshi Suzuki and Susumu Ohya

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 510-518; DOI: https://doi.org/10.1124/jpet.114.217315
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No Evidence for Histamine H₄ Receptor in Human Monocytes
Kristin Werner, Detlef Neumann, Armin Buschauer and Roland Seifert

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 519-526; DOI: https://doi.org/10.1124/jpet.114.218107

Drug Discovery and Translational Medicine

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Complement Inhibition in Cynomolgus Monkeys by Anti–Factor D Antigen-Binding Fragment for the Treatment of an Advanced Form of Dry Age-Related Macular Degeneration
Kelly M. Loyet, Jeremy Good, Teresa Davancaze, Lizette Sturgeon, Xiangdan Wang, Jihong Yang, Kha N. Le, Maureen Wong, Philip E. Hass, Menno van Lookeren Campagne, Peter C. Haughney, Alyssa Morimoto, Lisa A. Damico-Beyer and Laura E. DeForge

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 527-537; DOI: https://doi.org/10.1124/jpet.114.215921
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The Novel Kinase Inhibitor PRT062070 (Cerdulatinib) Demonstrates Efficacy in Models of Autoimmunity and B-Cell Cancer
Greg Coffey, Andreas Betz, Francis DeGuzman, Yvonne Pak, Mayuko Inagaki, Dale C. Baker, Stanley J. Hollenbach, Anjali Pandey and Uma Sinha

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 538-548; DOI: https://doi.org/10.1124/jpet.114.218164
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Atomoxetine Prevents Dexamethasone-Induced Skeletal Muscle Atrophy in Mice
Sean R. Jesinkey, Midhun C. Korrapati, Kyle A. Rasbach, Craig C. Beeson and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 663-673; DOI: https://doi.org/10.1124/jpet.114.217380
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A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High-Fat–Fed Mice
Brian D. Fink, Judith A. Herlein, Deng Fu Guo, Chaitanya Kulkarni, Benjamin J. Weidemann, Liping Yu, Justin L. Grobe, Kamal Rahmouni, Robert J. Kerns and William I. Sivitz

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 699-708; DOI: https://doi.org/10.1124/jpet.114.219329

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Specific Activin Receptor–Like Kinase 3 Inhibitors Enhance Liver Regeneration
Daisuke Tsugawa, Yuki Oya, Ryota Masuzaki, Kevin Ray, Darren W. Engers, Martin Dib, Nhue Do, Kaori Kuramitsu, Karen Ho, Audrey Frist, Paul B. Yu, Kenneth D. Bloch, Craig W. Lindsley, Corey R. Hopkins, Charles C. Hong and Seth J. Karp

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 549-558; DOI: https://doi.org/10.1124/jpet.114.216903
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Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium–Induced Colon Cancer
Jie Cheng, Zhong-Ze Fang, Kenjiro Nagaoka, Minoru Okamoto, Aijuan Qu, Naoki Tanaka, Shioko Kimura and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 559-567; DOI: https://doi.org/10.1124/jpet.114.215913

Inflammation, Immunopharmacology, and Asthma

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A Mouse Model of Peripheral Postischemic Dysesthesia: Involvement of Reperfusion-Induced Oxidative Stress and TRPA1 Channel
Atsushi Sasaki, Shizuka Mizoguchi, Kenta Kagaya, Mai Shiro, Akiho Sakai, Tsugunobu Andoh, Yurika Kino, Hiroyuki Taniguchi, Yukako Saito, Hiroki Takahata and Yasushi Kuraishi

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 568-575; DOI: https://doi.org/10.1124/jpet.114.217570
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Interleukin-Driven Insulin-Like Growth Factor Promotes Prostatic Inflammatory Hyperplasia
Alana M. Hahn, Jason D. Myers, Eliza K. McFarland, Sanghee Lee and Travis J. Jerde

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 605-615; DOI: https://doi.org/10.1124/jpet.114.218693

Metabolism, Transport, and Pharmacogenomics

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Assessment of a Candidate Marker Constituent Predictive of a Dietary Substance–Drug Interaction: Case Study with Grapefruit Juice and CYP3A4 Drug Substrates
Garrett R. Ainslie, Kristina K. Wolf, Yingxin Li, Elizabeth A. Connolly, Yolanda V. Scarlett, J. Heyward Hull and Mary F. Paine

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 576-584; DOI: https://doi.org/10.1124/jpet.114.216838
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Endocannabinoids Anandamide and 2-Arachidonoylglycerol Are Substrates for Human CYP2J2 Epoxygenase
Daniel R. McDougle, Amogh Kambalyal, Daryl D. Meling and Aditi Das

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 616-627; DOI: https://doi.org/10.1124/jpet.114.216598

Neuropharmacology

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Acute Effects of Brexpiprazole on Serotonin, Dopamine, and Norepinephrine Systems: An In Vivo Electrophysiologic Characterization
Chris A. Oosterhof, Mostafa El Mansari and Pierre Blier

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 585-595; DOI: https://doi.org/10.1124/jpet.114.218578
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The Human Ether-A-Go-Go–Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels
Ping Li, Xueqin Chen, Qiansen Zhang, Yueming Zheng, Hualiang Jiang, Huaiyu Yang and Zhaobing Gao

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 596-604; DOI: https://doi.org/10.1124/jpet.114.217703
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Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432
Brian Lord, Leah Aluisio, James R. Shoblock, Robert A. Neff, Elena I. Varlinskaya, Marc Ceusters, Timothy W. Lovenberg, Nicholas Carruthers, Pascal Bonaventure, Michael A. Letavic, Terrence Deak, Wilhelmus Drinkenburg and Anindya Bhattacharya

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 628-641; DOI: https://doi.org/10.1124/jpet.114.218487
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Neurophysiologic and Antipsychotic Profiles of TASP0433864, a Novel Positive Allosteric Modulator of Metabotropic Glutamate 2 Receptor
Tetsuaki Hiyoshi, Toshiyuki Marumo, Hirohiko Hikichi, Yasumitsu Tomishima, Hiroki Urabe, Tomoko Tamita, Izumi Iida, Akito Yasuhara, Jun-ichi Karasawa and Shigeyuki Chaki

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 642-653; DOI: https://doi.org/10.1124/jpet.114.218651
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Biphasic Modulation of Paracellular Claudin-5 Expression in Mouse Brain Endothelial Cells Is Mediated through the Phosphoinositide-3-Kinase/AKT Pathway
Ryan B. Camire, Holly J. Beaulac, Stephanie A. Brule, Annie I. McGregor, Emily E. Lauria and Colin L. Willis

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 654-662; DOI: https://doi.org/10.1124/jpet.114.218339
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The Antimalarial Drug Proguanil Is an Antagonist at 5-HT₃ Receptors
Martin Lochner and Andrew J. Thompson

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 674-684; DOI: https://doi.org/10.1124/jpet.114.218461

Toxicology

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Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans
Lijiang Shen, Ashley Frazer-Abel, Paul R. Reynolds, Patricia C. Giclas, Alfred Chappell, Michael K. Pangburn, Husam Younis and Scott P. Henry

Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 709-717; DOI: https://doi.org/10.1124/jpet.114.219378

Errata

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Correction to “Mimics of the Dimerization Domain of Hepatocyte Growth Factor Exhibit Anti-Met and Anticancer Activity”
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 685; DOI: https://doi.org/10.1124/jpet.113.185694err
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Correction to “Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of a Novel Serotonin-Dopamine Activity Modulator”
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 686-687; DOI: https://doi.org/10.1124/jpet.113.213819err

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Errata

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