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Research ArticleMinireviews

Dopamine D1 Receptor Signaling: Does GαQ–Phospholipase C Actually Play a Role?

Sang-Min Lee, Yang Yang and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 9-17; DOI: https://doi.org/10.1124/jpet.114.214411
Sang-Min Lee
Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
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Yang Yang
Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
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Richard B. Mailman
Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
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Journal of Pharmacology and Experimental Therapeutics: 351 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 351, Issue 1
1 Oct 2014
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Research ArticleMinireviews

Dopamine D1 Receptors and PLC

Sang-Min Lee, Yang Yang and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics October 1, 2014, 351 (1) 9-17; DOI: https://doi.org/10.1124/jpet.114.214411

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Research ArticleMinireviews

Dopamine D1 Receptors and PLC

Sang-Min Lee, Yang Yang and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics October 1, 2014, 351 (1) 9-17; DOI: https://doi.org/10.1124/jpet.114.214411
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  • Article
    • Abstract
    • The Potential Utility of a Functionally Selective D1 Ligand
    • SKF-83959, the First Functionally Selective D1 Ligand?
    • Hypothesis: SKF-83959 Is a Selective, High-Affinity D1 Ligand
    • Hypothesis: SKF-83959 Has No Intrinsic Activity at D1-Mediated Stimulation of Adenylate Cyclase
    • Hypothesis: SKF-83959 Activates PLC via a D1-GαQ Mechanism
    • Hypothesis: D1-D2 Heterodimer–Mediated Activation of GαQ-PLC-Ca2+ by D1-Selective Ligands Is an Important Signaling Mechanism
    • Hypothesis: D1-PLC Signaling of SKF-83959 Causes Novel Behavioral Effects
    • Reconciliation of the Role of D1 Receptors and GαQ-PLC Activation
    • Conclusions
    • Acknowledgments
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