Research ArticleMinireviews
Dopamine D1 Receptor Signaling: Does GαQ–Phospholipase C Actually Play a Role?
Sang-Min Lee, Yang Yang and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 9-17; DOI: https://doi.org/10.1124/jpet.114.214411
Sang-Min Lee
Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Yang Yang
Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Richard B. Mailman
Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania

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Research ArticleMinireviews
Dopamine D1 Receptors and PLC
Sang-Min Lee, Yang Yang and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics October 1, 2014, 351 (1) 9-17; DOI: https://doi.org/10.1124/jpet.114.214411
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- Article
- Abstract
- The Potential Utility of a Functionally Selective D1 Ligand
- SKF-83959, the First Functionally Selective D1 Ligand?
- Hypothesis: SKF-83959 Is a Selective, High-Affinity D1 Ligand
- Hypothesis: SKF-83959 Has No Intrinsic Activity at D1-Mediated Stimulation of Adenylate Cyclase
- Hypothesis: SKF-83959 Activates PLC via a D1-GαQ Mechanism
- Hypothesis: D1-D2 Heterodimer–Mediated Activation of GαQ-PLC-Ca2+ by D1-Selective Ligands Is an Important Signaling Mechanism
- Hypothesis: D1-PLC Signaling of SKF-83959 Causes Novel Behavioral Effects
- Reconciliation of the Role of D1 Receptors and GαQ-PLC Activation
- Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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