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History
- Received June 2, 2014
- Accepted July 21, 2014
- Published online August 27, 2014.
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- Earlier version (July 22, 2014 - 11:13).
- You are viewing the most recent version of this article.
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Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Sang-Min Lee,
- Yang Yang, and
- Richard B. Mailman
- Departments of Pharmacology (S.-M.L., Y.Y., R.B.M.) and Neurology (Y.Y., R.B.M.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania
- Address correspondence to:
Dr. Richard B. Mailman, Department of Pharmacology, Pennsylvania State University College of Medicine–Milton S. Hershey Medical Center, R130, 500 University Drive, P.O. Box 850, Hershey, PA 17033-0850. E-mail: rmailman{at}psu.edu
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- Article
- Abstract
- The Potential Utility of a Functionally Selective D1 Ligand
- SKF-83959, the First Functionally Selective D1 Ligand?
- Hypothesis: SKF-83959 Is a Selective, High-Affinity D1 Ligand
- Hypothesis: SKF-83959 Has No Intrinsic Activity at D1-Mediated Stimulation of Adenylate Cyclase
- Hypothesis: SKF-83959 Activates PLC via a D1-GαQ Mechanism
- Hypothesis: D1-D2 Heterodimer–Mediated Activation of GαQ-PLC-Ca2+ by D1-Selective Ligands Is an Important Signaling Mechanism
- Hypothesis: D1-PLC Signaling of SKF-83959 Causes Novel Behavioral Effects
- Reconciliation of the Role of D1 Receptors and GαQ-PLC Activation
- Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
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