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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2014; Volume 350,Issue 3

Highlighted Papers

  • You have access
    Small-Molecule Correctors To Restore F508del-CFTR Function and Processing
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HI
  • You have access
    Tanshinone II A Sulfonate Inhibits P2X7
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HIa
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    Empagliflozin Preserves β-Cell Mass and Restores Glucose Homeostasis in Diabetes
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HIb
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    Gambierol Augments Spontaneous Ca2+ Oscillations in Cerebrocortical Neurons
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HIc

Commentary

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    Hope for Disease-Modifying Treatment of Systemic Sclerosis/Scleroderma
    Martin C. Michel
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 480-482; DOI: https://doi.org/10.1124/jpet.114.213520comm

Minireview

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    Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies
    Lynne M. Howells, Jagdish Mahale, Stewart Sale, Laura McVeigh, William P. Steward, Anne Thomas and Karen Brown
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 483-494; DOI: https://doi.org/10.1124/jpet.114.216333

Cardiovascular

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    Different Compartmentation of Responses to Brain Natriuretic Peptide and C-Type Natriuretic Peptide in Failing Rat Ventricle
    Lise Román Moltzau, Jan Magnus Aronsen, Silja Meier, Jonas Skogestad, Øivind Ørstavik, Gustav B. Lothe, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy and Eirik Qvigstad
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 681-690; DOI: https://doi.org/10.1124/jpet.114.214882
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    Uptake and Protective Effects of Ergothioneine in Human Endothelial Cells
    Rachel W. S. Li, C. Yang, Albert S. M. Sit, Y. W. Kwan, Simon M. Y. Lee, Maggie P. M. Hoi, S. W. Chan, Marvin Hausman, Paul M. Vanhoutte and George P. H. Leung
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 691-700; DOI: https://doi.org/10.1124/jpet.114.214049
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    Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling
    Jeremy R. McGarvey, Sara Pettaway, James A. Shuman, Craig P. Novack, Kia N. Zellars, Parker D. Freels, Randall L. Echols, Jason A. Burdick, Joseph H. Gorman, Robert C. Gorman and Francis G. Spinale
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 701-709; DOI: https://doi.org/10.1124/jpet.114.215798

Cellular and Molecular

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    Searching for Combinations of Small-Molecule Correctors to Restore F508del–Cystic Fibrosis Transmembrane Conductance Regulator Function and Processing
    Clément Boinot, Mathilde Jollivet Souchet, Romain Ferru-Clément and Frédéric Becq
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 624-634; DOI: https://doi.org/10.1124/jpet.114.214890

Drug Discovery and Translational Medicine

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    Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
    Mikhail Kalinichev, Emmanuel Le Poul, Christelle Boléa, Françoise Girard, Brice Campo, Massimiliano Fonsi, Isabelle Royer-Urios, Susan E. Browne, Jason M. Uslaner, Matthew J. Davis, Jacob Raber, Robert Duvoisin, Simon T. Bate, Ian J. Reynolds, Sonia Poli and Sylvain Celanire
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 495-505; DOI: https://doi.org/10.1124/jpet.114.214437
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    Vimocin and Vidapin, Cyclic KTS Peptides, Are Dual Antagonists of α1β1/α2β1 Integrins with Antiangiogenic Activity
    Tatjana Momic, Jehoshua Katzehendler, Ofra Benny, Adi Lahiani, Gadi Cohen, Efrat Noy, Hanoch Senderowitz, Johannes A. Eble, Cezary Marcinkiewicz and Philip Lazarovici
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 506-519; DOI: https://doi.org/10.1124/jpet.114.214643
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    NS19504: A Novel BK Channel Activator with Relaxing Effect on Bladder Smooth Muscle Spontaneous Phasic Contractions
    Bernhard Nausch, Frederik Rode, Susanne Jørgensen, Antonio Nardi, Mads P. G. Korsgaard, Charlotte Hougaard, Adrian D. Bonev, William D. Brown, Tino Dyhring, Dorte Strøbæk, Søren-Peter Olesen, Palle Christophersen, Morten Grunnet, Mark T. Nelson and Lars C. B. Rønn
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 520-530; DOI: https://doi.org/10.1124/jpet.113.212662
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    Tanshinone II A Sulfonate, but Not Tanshinone II A, Acts as Potent Negative Allosteric Modulator of the Human Purinergic Receptor P2X7
    M. Kaiser, H. Sobottka, W. Fischer, M. Schaefer and W. Nörenberg
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 531-542; DOI: https://doi.org/10.1124/jpet.114.214569
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    Clinically Relevant Doses of Candesartan Inhibit Growth of Prostate Tumor Xenografts In Vivo through Modulation of Tumor Angiogenesis
    Ahmed Alhusban, Ahmad Al-Azayzih, Anna Goc, Fei Gao, Susan C. Fagan and Payaningal R. Somanath
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 635-645; DOI: https://doi.org/10.1124/jpet.114.216382
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    DOT1L Inhibitor EPZ-5676 Displays Synergistic Antiproliferative Activity in Combination with Standard of Care Drugs and Hypomethylating Agents in MLL-Rearranged Leukemia Cells
    Christine R. Klaus, Dorothy Iwanowicz, Danielle Johnston, Carly A. Campbell, Jesse J. Smith, Mikel P. Moyer, Robert A. Copeland, Edward J. Olhava, Margaret Porter Scott, Roy M. Pollock, Scott R. Daigle and Alejandra Raimondi
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 646-656; DOI: https://doi.org/10.1124/jpet.114.214577

Endocrine and Diabetes

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    The Sodium Glucose Cotransporter Type 2 Inhibitor Empagliflozin Preserves β-Cell Mass and Restores Glucose Homeostasis in the Male Zucker Diabetic Fatty Rat
    Henrik H. Hansen, Jacob Jelsing, Carl Frederik Hansen, Gitte Hansen, Niels Vrang, Michael Mark, Thomas Klein and Eric Mayoux
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 657-664; DOI: https://doi.org/10.1124/jpet.114.213454

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Characteristics of TRK-130 (Naltalimide), a Novel Opioid Ligand, as a New Therapeutic Agent for Overactive Bladder
    Morihiro Fujimura, Naoki Izumimoto, Shinobu Momen, Satoru Yoshikawa, Ryosuke Kobayashi, Sayoko Kanie, Mikito Hirakata, Toshikazu Komagata, Satoshi Okanishi, Tadatoshi Hashimoto, Naoki Yoshimura and Koji Kawai
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 543-551; DOI: https://doi.org/10.1124/jpet.114.214031
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    Astragaloside IV Ameliorates Renal Fibrosis via the Inhibition of Mitogen-Activated Protein Kinases and Antiapoptosis In Vivo and In Vitro
    Weijia Xu, Xinghua Shao, Lei Tian, Leyi Gu, Minfang Zhang, Qin Wang, Bei Wu, Ling Wang, Jufang Yao, Xiaoping Xu, Shan Mou and Zhaohui Ni
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 552-562; DOI: https://doi.org/10.1124/jpet.114.214205
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    The Guanosine-Adenosine Interaction Exists In Vivo
    Edwin K. Jackson and Zaichuan Mi
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 719-726; DOI: https://doi.org/10.1124/jpet.114.216978

Inflammation, Immunopharmacology, and Asthma

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    RhoA/Phosphatidylinositol 3-Kinase/Protein Kinase B/Mitogen-Activated Protein Kinase Signaling after Growth Arrest–Specific Protein 6/Mer Receptor Tyrosine Kinase Engagement Promotes Epithelial Cell Growth and Wound Repair via Upregulation of Hepatocyte Growth Factor in Macrophages
    Ye-Ji Lee, Hyun-Jung Park, So-Youn Woo, Eun-Mi Park and Jihee Lee Kang
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 563-577; DOI: https://doi.org/10.1124/jpet.114.215673

Metabolism, Transport, and Pharmacogenomics

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    Blood-Brain Barrier Pharmacoproteomics-Based Reconstruction of the In Vivo Brain Distribution of P-Glycoprotein Substrates in Cynomolgus Monkeys
    Yasuo Uchida, Kentaro Wakayama, Sumio Ohtsuki, Masato Chiba, Tomoyuki Ohe, Yasuyuki Ishii and Tetsuya Terasaki
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 578-588; DOI: https://doi.org/10.1124/jpet.114.214536

Neuropharmacology

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    Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
    Kenji Maeda, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Jun Shimada, Takashi Futamura, Hiroshi Yamashita, Nobuaki Ito, Robert D. McQuade, Arne Mørk, Alan L. Pehrson, Morten Hentzer, Vibeke Nielsen, Christoffer Bundgaard, Jørn Arnt, Tine Bryan Stensbøl and Tetsuro Kikuchi
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 589-604; DOI: https://doi.org/10.1124/jpet.114.213793
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    Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of a Novel Serotonin-Dopamine Activity Modulator
    Kenji Maeda, Linda Lerdrup, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Robert D. McQuade, Tine Bryan Stensbøl, Christoffer Bundgaard, Jørn Arnt and Tetsuro Kikuchi
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 605-614; DOI: https://doi.org/10.1124/jpet.114.213819
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    The Minimal Pharmacophore for Silent Agonism of the α7 Nicotinic Acetylcholine Receptor
    Roger L. Papke, Kinga Chojnacka and Nicole A. Horenstein
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 665-680; DOI: https://doi.org/10.1124/jpet.114.215236
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    Pharmacologic Characterization in the Rat of a Potent Analgesic Lacking Respiratory Depression, IBNtxA
    Steven G. Grinnell, Susruta Majumdar, Ankita Narayan, Valerie Le Rouzic, Michael Ansonoff, John E. Pintar and Gavril W. Pasternak
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 710-718; DOI: https://doi.org/10.1124/jpet.114.213199

Toxicology

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    Gambierol Inhibition of Voltage-Gated Potassium Channels Augments Spontaneous Ca2+ Oscillations in Cerebrocortical Neurons
    Zhengyu Cao, Yanjun Cui, Eric Busse, Suneet Mehrotra, Jon D. Rainier and Thomas F. Murray
    Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 615-623; DOI: https://doi.org/10.1124/jpet.114.215319
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 350 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 350, Issue 3
1 Sep 2014
  • Table of Contents
  • Table of Contents (PDF)
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  • Highlighted Papers
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  • Cardiovascular
  • Cellular and Molecular
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  • Endocrine and Diabetes
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  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Toxicology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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