Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleBehavioral Pharmacology

Differential Substitution for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate in Rats

Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama and Tsutomu Suzuki
Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 403-411; DOI: https://doi.org/10.1124/jpet.114.214288
Tomohisa Mori
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naoki Uzawa
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haruyo Kazawa
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hirohiko Watanabe
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ayano Mochizuki
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masahiro Shibasaki
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazumi Yoshizawa
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kimio Higashiyama
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tsutomu Suzuki
Department of Toxicology (T.M., N.U., H.K., H.W., A.M., M.S., T.S.) and Institute of Medicinal Chemistry (K.H.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; and Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan (K.Y.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Previous studies have demonstrated that methylphenidate, MDMA (3,4-methylenedioxymethamphetamine), and other psychostimulants exert stimulant-like subjective effects in humans. Furthermore, MDMA and methylphenidate substitute for the discriminative stimulus effects of psychostimulants, such as amphetamine and cocaine, in animals, which suggests that MDMA and methylphenidate may produce similar discriminative stimulus effects in rats. However, there is no evidence regarding the similarities between the discriminative stimulus effects of MDMA and methylphenidate. To explore this issue, cross-substitution, substitution, and combination tests were conducted in rats that had been trained to discriminate between MDMA (2.5 mg/kg) or methylphenidate (5.0 mg/kg) and saline. In the cross-substitution tests, MDMA and methylphenidate did not cross-substitute for each other. In the substitution test, methamphetamine substituted for the discriminative stimulus effects of methylphenidate, but not for those of MDMA. Furthermore, ephedrine and bupropion, which activate dopaminergic and noradrenergic systems, substituted for the discriminative stimulus effects of methylphenidate. On the other hand, serotonin (5-HT) receptor agonists 5-HT1A and 5-HT2 fully substituted for the discriminative stimulus effects of MDMA. These results suggest that activation of the noradrenergic and dopaminergic systems is important for the discriminative stimulus effects of methylphenidate, whereas activation of the serotonergic system is crucial for the discriminative stimulus effects of MDMA. Even though MDMA, like psychostimulants, exerts stimulant-like effects, our findings clearly indicate that the discriminative stimulus effects of MDMA are distinctly different from those of other psychostimulants in rats.

Footnotes

    • Received March 5, 2014.
    • Accepted June 6, 2014.
  • This work was supported in part by grants for Research on Regulatory Science of Pharmaceuticals and Medical Devices from the Ministry of Health, Labour, and Welfare, Japan (to T.S. and/or T.M.).

  • dx.doi.org/10.1124/jpet.114.214288.

  • Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 350 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 350, Issue 2
1 Aug 2014
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Differential Substitution for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate in Rats
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleBehavioral Pharmacology

Differential Stimulus Effects of MDMA and Methylphenidate

Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama and Tsutomu Suzuki
Journal of Pharmacology and Experimental Therapeutics August 1, 2014, 350 (2) 403-411; DOI: https://doi.org/10.1124/jpet.114.214288

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleBehavioral Pharmacology

Differential Stimulus Effects of MDMA and Methylphenidate

Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama and Tsutomu Suzuki
Journal of Pharmacology and Experimental Therapeutics August 1, 2014, 350 (2) 403-411; DOI: https://doi.org/10.1124/jpet.114.214288
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Daily Methocinnamox and Fentanyl Self-Administration
  • Efficacy as a Determinant of Hyperlocomotion by MOR Ligands
  • Abuse Potential of Botanical Cannabidiol
Show more Behavioral Pharmacology

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics