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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2014; Volume 350,Issue 2

Highlighted Papers

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    Circulating Protein Adducts in Diclofenac Patients
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HI
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    Casein Kinase II Regulates Synaptic Plasticity in Neuropathic Pain
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HIa
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    PHPB Attenuates Symptoms in a Mouse Model of Alzheimer’s Disease
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HIb
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    Structure and Pharmacodynamics of an Adnectin PCSK9 Inhibitor
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HIc

Perspectives in Pharmacology

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    Repurposing Miltefosine for the Treatment of Immune-Mediated Disease?
    Auke P. Verhaar, Manon E. Wildenberg, Maikel P. Peppelenbosch, Daniel W. Hommes and Gijs R. van den Brink
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 189-195; DOI: https://doi.org/10.1124/jpet.113.212654
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    Animal Models That Best Reproduce the Clinical Manifestations of Human Intoxication with Organophosphorus Compounds
    Edna F. R. Pereira, Yasco Aracava, Louis J. DeTolla, E. Jeffrey Beecham, G. William Basinger, Edgar J. Wakayama and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 313-321; DOI: https://doi.org/10.1124/jpet.114.214932

Behavioral Pharmacology

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    Prolonged Monoacylglycerol Lipase Blockade Causes Equivalent Cannabinoid Receptor Type 1 Receptor–Mediated Adaptations in Fatty Acid Amide Hydrolase Wild-Type and Knockout Mice
    Joel E. Schlosburg, Steven G. Kinsey, Bogna Ignatowska-Jankowska, Divya Ramesh, Rehab A. Abdullah, Qing Tao, Lamont Booker, Jonathan Z. Long, Dana E. Selley, Benjamin F. Cravatt and Aron H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 196-204; DOI: https://doi.org/10.1124/jpet.114.212753
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    Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys
    Susan E. Martelle, Susan H. Nader, Paul W. Czoty, William S. John, Angela N. Duke, Pradeep K. Garg, Sudha Garg, Amy H. Newman and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 205-211; DOI: https://doi.org/10.1124/jpet.114.214833
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    AZD9272 and AZD2066: Selective and Highly Central Nervous System Penetrant mGluR5 Antagonists Characterized by Their Discriminative Effects
    Michael D. B. Swedberg and Patrick Raboisson
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 212-222; DOI: https://doi.org/10.1124/jpet.114.215137
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    Different Contributions of Dopamine D1 and D2 Receptor Activity to Alcohol Potentiation of Brain Stimulation Reward in C57BL/6J and DBA/2J Mice
    Eric W. Fish, Jeffrey F. DiBerto, Michael C. Krouse, J. Elliott Robinson and C. J. Malanga
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 322-329; DOI: https://doi.org/10.1124/jpet.114.216135
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    Differential Substitution for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate in Rats
    Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama and Tsutomu Suzuki
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 403-411; DOI: https://doi.org/10.1124/jpet.114.214288

Cardiovascular

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    Prediction and Modeling of Effects on the QTc Interval for Clinical Safety Margin Assessment, Based on Single-Ascending-Dose Study Data with AZD3839
    Erik Sparve, Angelica L. Quartino, Maria Lüttgen, Karin Tunblad, Anna Teiling Gårdlund, Johanna Fälting, Robert Alexander, Jens Kågström, Linnea Sjödin, Alexander Bulgak, Ahmad Al-Saffar, Matthew Bridgland-Taylor, Chris Pollard, Michael D. B. Swedberg, Torbjörn Vik and Björn Paulsson
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 469-478; DOI: https://doi.org/10.1124/jpet.114.215202

Cellular and Molecular

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    Mouse Monoclonal Antibodies to Transient Receptor Potential Ankyrin 1 Act as Antagonists of Multiple Modes of Channel Activation
    Ki Jeong Lee, Weiya Wang, Rupa Padaki, Vivian Bi, Cherylene A. Plewa and Narender R. Gavva
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 223-231; DOI: https://doi.org/10.1124/jpet.114.215574

Drug Discovery and Translational Medicine

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    Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation
    Tomoko Hayashi, Brian Crain, Shiyin Yao, Christa D. Caneda, Howard B. Cottam, Michael Chan, Maripat Corr and Dennis A. Carson
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 330-340; DOI: https://doi.org/10.1124/jpet.114.214312
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    3,3′-Diindolylmethane Ameliorates Experimental Autoimmune Encephalomyelitis by Promoting Cell Cycle Arrest and Apoptosis in Activated T Cells through MicroRNA Signaling Pathways
    Michael Rouse, Roshni Rao, Mitzi Nagarkatti and Prakash S. Nagarkatti
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 341-352; DOI: https://doi.org/10.1124/jpet.114.214742
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    Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering
    Tracy Mitchell, Ginger Chao, Doree Sitkoff, Fred Lo, Hossain Monshizadegan, Daniel Meyers, Simon Low, Katie Russo, Rose DiBella, Fabienne Denhez, Mian Gao, Joseph Myers, Gerald Duke, Mark Witmer, Bowman Miao, Siew P. Ho, Javed Khan and Rex A. Parker
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 412-424; DOI: https://doi.org/10.1124/jpet.114.214221

Endocrine and Diabetes

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    Effect of LX4211 on Glucose Homeostasis and Body Composition in Preclinical Models
    David R. Powell, Christopher M. DaCosta, Melinda Smith, Deon Doree, Angela Harris, Lindsey Buhring, William Heydorn, Amr Nouraldeen, Wendy Xiong, Padmaja Yalamanchili, Faika Mseeh, Alan Wilson, Melanie Shadoan, Brian Zambrowicz and Zhi-Ming Ding
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 232-242; DOI: https://doi.org/10.1124/jpet.114.214304
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    The Novel GLP-1–Gastrin Dual Agonist ZP3022 Improves Glucose Homeostasis and Increases β-Cell Mass without Affecting Islet Number in db/db Mice
    Louise S. Dalbøge, Dorthe L. C. Almholt, Trine S. R. Neerup, Niels Vrang, Jacob Jelsing and Keld Fosgerau
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 353-360; DOI: https://doi.org/10.1124/jpet.114.215293
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    Maternal-Fetal Disposition of Glyburide in Pregnant Mice Is Dependent on Gestational Age
    Diana L. Shuster, Linda J. Risler, Chao-Kang J. Liang, Kenneth M. Rice, Danny D. Shen, Mary F. Hebert, Kenneth E. Thummel and Qingcheng Mao
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 425-434; DOI: https://doi.org/10.1124/jpet.114.213470

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Blocking Sirtuin 1 and 2 Inhibits Renal Interstitial Fibroblast Activation and Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy
    Murugavel Ponnusamy, Xiaoxu Zhou, Yanli Yan, Jinhua Tang, Evelyn Tolbert, Ting C. Zhao, Rujun Gong and Shougang Zhuang
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 243-256; DOI: https://doi.org/10.1124/jpet.113.212076
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    Agonism of the 5-Hydroxytryptamine 1F Receptor Promotes Mitochondrial Biogenesis and Recovery from Acute Kidney Injury
    Sara M. Garrett, Ryan M. Whitaker, Craig C. Beeson and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 257-264; DOI: https://doi.org/10.1124/jpet.114.214700

Inflammation, Immunopharmacology, and Asthma

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    Inhibitory Effect of Baicalin on Collagen-Induced Arthritis in Rats through the Nuclear Factor–κB Pathway
    Hong-Zhi Wang, Hai-He Wang, Shi-Shun Huang, Hong Zhao, Yong-Gang Cao, Guang-Zhi Wang, Dong Wang, Zhi-Gang Wang and Yan-Hong Liu
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 435-443; DOI: https://doi.org/10.1124/jpet.114.215145
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    Antiallergic and Antiasthmatic Effects of a Novel Enhydrazinone Ester (CEE-1): Inhibition of Activation of Both Mast Cells and Eosinophils
    Charles I. Ezeamuzie, Ahmed Z. El-Hashim, Waleed M. Renno and Ivan O. Edafiogho
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 444-454; DOI: https://doi.org/10.1124/jpet.114.213751

Metabolism, Transport, and Pharmacogenomics

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    Modeling and Simulation to Probe the Pharmacokinetic Disposition of Pomalidomide R- and S-Enantiomers
    Yan Li, Simon Zhou, Matthew Hoffmann, Gondi Kumar and Maria Palmisano
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 265-272; DOI: https://doi.org/10.1124/jpet.114.215251

Neuropharmacology

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    Novel N-Phenyl–Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity
    Sina Oppermann, Florian C. Schrader, Katharina Elsässer, Amalia M. Dolga, Anna Lena Kraus, Nunzianna Doti, Christof Wegscheid-Gerlach, Martin Schlitzer and Carsten Culmsee
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 273-289; DOI: https://doi.org/10.1124/jpet.114.213777
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    Sigma-1 Receptor Antagonism Restores Injury-Induced Decrease of Voltage-Gated Ca2+ Current in Sensory Neurons
    Bin Pan, Yuan Guo, Wai-Meng Kwok, Quinn Hogan and Hsiang-en Wu
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 290-300; DOI: https://doi.org/10.1124/jpet.114.214320
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    Casein Kinase II Regulates N-Methyl-d-Aspartate Receptor Activity in Spinal Cords and Pain Hypersensitivity Induced by Nerve Injury
    Shao-Rui Chen, Hong-Yi Zhou, Hee Sun Byun, Hong Chen and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 301-312; DOI: https://doi.org/10.1124/jpet.114.215855
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    Potassium 2-(1-Hydroxypentyl)-Benzoate Improves Memory Deficits and Attenuates Amyloid and τ Pathologies in a Mouse Model of Alzheimer's Disease
    Ying Peng, Yanli Hu, Shaofeng Xu, Xianfang Rong, Jiang Li, PingPing Li, Ling Wang, Jinghua Yang and Xiaoliang Wang
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 361-374; DOI: https://doi.org/10.1124/jpet.114.213140
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    The [18F]FDG μPET Readout of a Brain Activation Model to Evaluate the Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator JNJ-42153605
    Tine Wyckhuys, Leonie wyffels, Xavier Langlois, Mark Schmidt, Sigrid Stroobants and Steven Staelens
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 375-386; DOI: https://doi.org/10.1124/jpet.114.213959
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    Characterization of RO5126946, a Novel α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator
    Sunil Sahdeo, Tanya Wallace, Ryoko Hirakawa, Frederic Knoflach, Daniel Bertrand, Hans Maag, Dinah Misner, Geoffrey C. Tombaugh, Luca Santarelli, Ken Brameld, Marcos E. Milla and Donald C. Button
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 455-468; DOI: https://doi.org/10.1124/jpet.113.210963

Toxicology

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    Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients
    Thomas G. Hammond, Xiaoli Meng, Rosalind E. Jenkins, James L. Maggs, Anahi Santoyo Castelazo, Sophie L. Regan, Stuart N. L. Bennett, Caroline J. Earnshaw, Guruprasad P. Aithal, Ira Pande, J. Gerry Kenna, Andrew V. Stachulski, B. Kevin Park and Dominic P. Williams
    Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 387-402; DOI: https://doi.org/10.1124/jpet.114.215079
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Journal of Pharmacology and Experimental Therapeutics: 350 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 350, Issue 2
1 Aug 2014
  • Table of Contents
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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