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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

July 01, 2014; Volume 350,Issue 1

Highlighted Papers

  • You have access
    H4 Antagonist, JNJ 39758979, Inhibits Histamine-Induced Pruritus in the Clinic
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0714HI
  • You have access
    SOMG-833, a Novel, Selective c-MET Inhibitor, Exerts Antitumor Activity
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0714HIa
  • You have access
    Ameliorative Effect of Mepenzolate Bromide against Pulmonary Fibrosis
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0714HIb
  • You have access
    A Livestock Feed Additive Is a Full Agonist at Trace Amine–Associated Receptor 1
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0714HIc

Commentary

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    Therapeutic Efficacy of a H4 Receptor Antagonist in Humans: A Milestone in Histamine Research
    Roland Seifert
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 2-4; DOI: https://doi.org/10.1124/jpet.114.215749comm

Behavioral Pharmacology

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    Effects of Pharmacologic Dopamine β-Hydroxylase Inhibition on Cocaine-Induced Reinstatement and Dopamine Neurochemistry in Squirrel Monkeys
    Debra A. Cooper, Heather L. Kimmel, Daniel F. Manvich, Karl T. Schmidt, David Weinshenker and Leonard L. Howell
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 144-152; DOI: https://doi.org/10.1124/jpet.113.212357
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    Potent Inhibition of Alcohol Self-Administration in Alcohol-Preferring Rats by a κ-Opioid Receptor Antagonist
    John R. Cashman and Marc R. Azar
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 171-180; DOI: https://doi.org/10.1124/jpet.114.214262

Cardiovascular

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    Ramipril Protects the Endothelium from High Glucose–Induced Dysfunction through CaMKKβ/AMPK and Heme Oxygenase-1 Activation
    Shiliu Tian, Xinfa Ge, Ke Wu, Huabing Yang and Yu Liu
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 5-13; DOI: https://doi.org/10.1124/jpet.114.212928
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    The Biological Actions of 11,12-Epoxyeicosatrienoic Acid in Endothelial Cells Are Specific to the R/S-Enantiomer and Require the Gs Protein
    Yindi Ding, Timo Frömel, Rüdiger Popp, John R. Falck, Wolf-Hagen Schunck and Ingrid Fleming
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 14-21; DOI: https://doi.org/10.1124/jpet.114.214254

Cellular and Molecular

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    Inhibition of Phosphatidylinositol 3-Kinase/AKT Signaling by NVP-BKM120 Promotes ABT-737–Induced Toxicity in a Caspase-Dependent Manner through Mitochondrial Dysfunction and DNA Damage Response in Established and Primary Cultured Glioblastoma Cells
    Esther P. Jane, Daniel R. Premkumar, Alejandro Morales, Kimberly A. Foster and Ian F. Pollack
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 22-35; DOI: https://doi.org/10.1124/jpet.114.212910

Drug Discovery and Translational Medicine

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    SOMG-833, a Novel Selective c-MET Inhibitor, Blocks c-MET–Dependent Neoplastic Effects and Exerts Antitumor Activity
    Hao-tian Zhang, Lu Wang, Jing Ai, Yi Chen, Chang-xi He, Yin-chun Ji, Min Huang, Jing-yu Yang, Ao Zhang, Jian Ding and Mei-yu Geng
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 36-45; DOI: https://doi.org/10.1124/jpet.114.214817
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    Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl–Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates
    Frank Rigo, Seung J. Chun, Daniel A. Norris, Gene Hung, Sam Lee, John Matson, Robert A. Fey, Hans Gaus, Yimin Hua, John S. Grundy, Adrian R. Krainer, Scott P. Henry and C. Frank Bennett
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 46-55; DOI: https://doi.org/10.1124/jpet.113.212407
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    Semisynthetic Bile Acid FXR and TGR5 Agonists: Physicochemical Properties, Pharmacokinetics, and Metabolism in the Rat
    Aldo Roda, Roberto Pellicciari, Antimo Gioiello, Flavia Neri, Cecilia Camborata, Daniela Passeri, Francesca De Franco, Silvia Spinozzi, Carolina Colliva, Luciano Adorini, Marco Montagnani and Rita Aldini
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 56-68; DOI: https://doi.org/10.1124/jpet.114.214650
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    GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species
    A. Richard Rutter, Alessandro Poffe, Palmina Cavallini, T. Gregg Davis, Jessica Schneck, Michele Negri, Elena Vicentini, Dino Montanari, Roberto Arban, Frank A. Gray, Ceri H. Davies and Paul B. Wren
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 153-163; DOI: https://doi.org/10.1124/jpet.114.214155
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    The Histamine H4 Receptor Antagonist, JNJ 39758979, Is Effective in Reducing Histamine-Induced Pruritus in a Randomized Clinical Study in Healthy Subjects
    Alexa Kollmeier, Klaus Francke, Bin Chen, Paul J. Dunford, Andrew J. Greenspan, Yichuan Xia, Xie L. Xu, Bei Zhou and Robin L. Thurmond
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 181-187; DOI: https://doi.org/10.1124/jpet.114.215749

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Novel Orally Available Salvinorin A Analog PR-38 Inhibits Gastrointestinal Motility and Reduces Abdominal Pain in Mouse Models Mimicking Irritable Bowel Syndrome
    M. Sałaga, P. R. Polepally, M. Sobczak, D. Grzywacz, W. Kamysz, A. Sibaev, M. Storr, J. C. Do Rego, J. K. Zjawiony and J. Fichna
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 69-78; DOI: https://doi.org/10.1124/jpet.114.214239
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    Ameliorative Effect of Mepenzolate Bromide against Pulmonary Fibrosis
    Shota Kurotsu, Ken-ichiro Tanaka, Tomomi Niino, Teita Asano, Toshifumi Sugizaki, Arata Azuma, Hidekazu Suzuki and Tohru Mizushima
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 79-88; DOI: https://doi.org/10.1124/jpet.114.213009
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    Hypercontractility of Intestinal Longitudinal Smooth Muscle Induced by Cytokines Is Mediated by the Nuclear Factor-κB/AMP-Activated Kinase/Myosin Light Chain Kinase Pathway
    Ancy D. Nalli, Divya P. Kumar, Sunila Mahavadi, Othman Al-Shboul, Reem Alkahtani, John F. Kuemmerle, John R. Grider and Karnam S. Murthy
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 89-98; DOI: https://doi.org/10.1124/jpet.113.212522

Inflammation, Immunopharmacology, and Asthma

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    Role of microRNAs in Resveratrol-Mediated Mitigation of Colitis-Associated Tumorigenesis in ApcMin/+ Mice
    Ibrahim Altamemi, E. Angela Murphy, James F. Catroppo, Elizabeth E. Zumbrun, Jiajia Zhang, Jamie L. McClellan, Udai P. Singh, Prakash S. Nagarkatti and Mitzi Nagarkatti
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 99-109; DOI: https://doi.org/10.1124/jpet.114.213306

Neuropharmacology

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    Structure of the LINGO-1–Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy
    R. Blake Pepinsky, Joseph W. Arndt, Chao Quan, Yan Gao, Omar Quintero-Monzon, Xinhua Lee and Sha Mi
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 110-123; DOI: https://doi.org/10.1124/jpet.113.211771
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    Ractopamine, a Livestock Feed Additive, Is a Full Agonist at Trace Amine–Associated Receptor 1
    Xuehong Liu, David K. Grandy and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 124-129; DOI: https://doi.org/10.1124/jpet.114.213116

Toxicology

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    Macitentan Does Not Interfere with Hepatic Bile Salt Transport
    Alexander Treiber, Päivi Äänismaa, Ruben de Kanter, Stephane Delahaye, Marianne Treher, Patrick Hess and Patricia Sidharta
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 130-143; DOI: https://doi.org/10.1124/jpet.114.214106
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    Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response
    Kyle L. Poulsen, Jesus Olivero-Verbel, Kevin M. Beggs, Patricia E. Ganey and Robert A. Roth
    Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 164-170; DOI: https://doi.org/10.1124/jpet.114.214189
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 350 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 350, Issue 1
1 Jul 2014
  • Table of Contents
  • Table of Contents (PDF)
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  • Highlighted Papers
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  • Inflammation, Immunopharmacology, and Asthma
  • Neuropharmacology
  • Toxicology
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