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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2014; Volume 349,Issue 3

Highlighted Papers

  • You have access
    Bryostatin-1 Restores Hippocampal Synapses, Learning, and Memory in Fragile X Mice
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HI
  • You have access
    Histamine H4-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HIa
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    Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Intoxication
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HIb
  • You have access
    Lubiprostone Prevents Nonsteroidal Anti-Inflammatory Drug–Induced Small Intestinal Damage via EP4 Receptors
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HIc

Behavioral Pharmacology

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    Bryostatin-1 Restores Hippocampal Synapses and Spatial Learning and Memory in Adult Fragile X Mice
    Miao-Kun Sun, Jarin Hongpaisan, Chol Seung Lim and Daniel L. Alkon
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 393-401; DOI: https://doi.org/10.1124/jpet.114.214098

Cardiovascular

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    Histamine H4-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion via Protein Kinase Cε-Dependent Aldehyde Dehydrogenase Type-2 Activation
    Silvia Aldi, Ken-ichi Takano, Kengo Tomita, Kenichiro Koda, Noel Y.-K. Chan, Alice Marino, Mariselis Salazar-Rodriguez, Robin L. Thurmond and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 508-517; DOI: https://doi.org/10.1124/jpet.114.214122

Cellular and Molecular

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    A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors
    John O. DiRaddo, Eric J. Miller, Hannah A. Hathaway, Ewa Grajkowska, Barbara Wroblewska, Barry B. Wolfe, Dennis C. Liotta and Jarda T. Wroblewski
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 373-382; DOI: https://doi.org/10.1124/jpet.113.211532
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    BAY60-6583 Acts as a Partial Agonist at Adenosine A2B Receptors
    Sonja Hinz, Svenja K. Lacher, Benjamin F. Seibt and Christa E. Müller
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 427-436; DOI: https://doi.org/10.1124/jpet.113.210849
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    Activation of Estrogen Receptor α Enhances Bradykinin Signaling in Peripheral Sensory Neurons of Female Rats
    Matthew P. Rowan, Kelly A. Berg, James L. Roberts, Kenneth M. Hargreaves and William P. Clarke
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 526-532; DOI: https://doi.org/10.1124/jpet.114.212977

Chemotherapy, Antibiotics, and Gene Therapy

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    Rationale for Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Combination Therapy with Camptothecins or Temozolomide Based on PARP Trapping versus Catalytic Inhibition
    Junko Murai, Yiping Zhang, Joel Morris, Jiuping Ji, Shunichi Takeda, James H. Doroshow and Yves Pommier
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 408-416; DOI: https://doi.org/10.1124/jpet.113.210146
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    Preclinical Characterization of Signal Transducer and Activator of Transcription 3 Small Molecule Inhibitors for Primary and Metastatic Brain Cancer Therapy
    Hikmat H. Assi, Chris Paran, Nathan VanderVeen, Jonathan Savakus, Robert Doherty, Emanuele Petruzzella, James D. Hoeschele, Henry Appelman, Leda Raptis, Tom Mikkelsen, Pedro R. Lowenstein and Maria G. Castro
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 458-469; DOI: https://doi.org/10.1124/jpet.114.214619
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    Investigation of Evolved Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Compound Intoxication
    David G. Mata, Peter E. Rezk, Praveena Sabnekar, Douglas M. Cerasoli and Nageswararao Chilukuri
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 549-558; DOI: https://doi.org/10.1124/jpet.114.213645

Drug Discovery and Translational Medicine

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    Identification of a Novel Small-Molecule Agonist for Human G Protein–Coupled Receptor 3
    Chenli Ye, Zhenghong Zhang, Zhilong Wang, Qiuhong Hua, Ru Zhang and Xin Xie
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 437-443; DOI: https://doi.org/10.1124/jpet.114.213082
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    Candesartan Induces a Prolonged Proangiogenic Effect and Augments Endothelium-Mediated Neuroprotection after Oxygen and Glucose Deprivation: Role of Vascular Endothelial Growth Factors A and B
    Sahar Soliman, Tauheed Ishrat, Anilkumar Pillai, Payaningal R. Somanath, Adviye Ergul, Azza B. El-Remessy and Susan C. Fagan
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 444-457; DOI: https://doi.org/10.1124/jpet.113.212613
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    Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Model of Skin Injury
    Andrew J. Haak, Pei-Suen Tsou, Mohammad A. Amin, Jeffrey H. Ruth, Phillip Campbell, David A. Fox, Dinesh Khanna, Scott D. Larsen and Richard R. Neubig
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 480-486; DOI: https://doi.org/10.1124/jpet.114.213520
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    A Monoclonal Antibody Specific for 6-Monoacetylmorphine Reduces Acute Heroin Effects in Mice
    Inger Lise Bogen, Fernando Boix, Elisabeth Nerem, Jørg Mørland and Jannike Mørch Andersen
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 568-576; DOI: https://doi.org/10.1124/jpet.113.212035

Endocrine and Diabetes

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    Treatment with the 3-Ketoacyl-CoA Thiolase Inhibitor Trimetazidine Does Not Exacerbate Whole-Body Insulin Resistance in Obese Mice
    John R. Ussher, Wendy Keung, Natasha Fillmore, Timothy R. Koves, Jun Mori, Liyan Zhang, David G. Lopaschuk, Olga R. Ilkayeva, Cory S. Wagg, Jagdip S. Jaswal, Deborah M. Muoio and Gary D. Lopaschuk
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 487-496; DOI: https://doi.org/10.1124/jpet.114.214197

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    The Antifibrinolytic Drug Tranexamic Acid Reduces Liver Injury and Fibrosis in a Mouse Model of Chronic Bile Duct Injury
    Nikita Joshi, Anna K. Kopec, Keara Towery, Kurt J. Williams and James P. Luyendyk
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 383-392; DOI: https://doi.org/10.1124/jpet.113.210880
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    Effects of Duloxetine and WAY100635 on Pudendal Inhibition of Bladder Overactivity in Cats
    Jeremy Reese, Zhiying Xiao, Zeyad Schwen, Yosuke Matsuta, Bing Shen, Jicheng Wang, James R. Roppolo, William C. de Groat and Changfeng Tai
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 402-407; DOI: https://doi.org/10.1124/jpet.113.211557
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    Lubiprostone Prevents Nonsteroidal Anti-Inflammatory Drug–Induced Small Intestinal Damage by Suppressing the Expression of Inflammatory Mediators via EP4 Receptors
    Shusaku Hayashi, Naoto Kurata, Aya Yamaguchi, Kikuko Amagase and Koji Takeuchi
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 470-479; DOI: https://doi.org/10.1124/jpet.114.213991
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    The Water-Soluble Triptolide Derivative PG490-88 Protects against Cisplatin-Induced Acute Kidney Injury
    Hyun-Jung Kim, Kameswaran Ravichandran, Abdullah Ozkok, Qian Wang, Zhibin He, Alkesh Jani, Danica Ljubanovic, Ivor S. Douglas and Charles L. Edelstein
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 518-525; DOI: https://doi.org/10.1124/jpet.114.213769

Inflammation, Immunopharmacology, and Asthma

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    Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats
    Yong Zhang, Xiaoguang Li, Qingwei Zhang, Jiamin Li, Jiaming Ju, Ning Du, Xin Liu, Xiaohui Chen, Feiran Cheng, Lei Yang, Chaoqian Xu, Muhammad U. Bilal, Yunwei Wei, Yanjie Lu and Baofeng Yang
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 417-426; DOI: https://doi.org/10.1124/jpet.114.212795

Neuropharmacology

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    Rapid Transport of CCL11 across the Blood-Brain Barrier: Regional Variation and Importance of Blood Cells
    Michelle A. Erickson, Yoichi Morofuji, Joshua B. Owen and William A. Banks
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 497-507; DOI: https://doi.org/10.1124/jpet.114.213074
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    Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist
    Klaus Linz, Thomas Christoph, Thomas M. Tzschentke, Thomas Koch, Klaus Schiene, Michael Gautrois, Wolfgang Schröder, Babette Y. Kögel, Horst Beier, Werner Englberger, Stefan Schunk, Jean De Vry, Ulrich Jahnel and Stefanie Frosch
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 535-548; DOI: https://doi.org/10.1124/jpet.114.213694
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    Acute Ethanol Inhibits Dopamine Release in the Nucleus Accumbens via α6 Nicotinic Acetylcholine Receptors
    Nathan D. Schilaty, David M. Hedges, Eun Young Jang, Ryan J. Folsom, Jordan T. Yorgason, J. Michael McIntosh and Scott C. Steffensen
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 559-567; DOI: https://doi.org/10.1124/jpet.113.211490

Errata

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    Correction to “A Novel Aminotetralin-Type Serotonin (5-HT) 2C Receptor-Specific Agonist and 5-HT2A Competitive Antagonist/5-HT2B Inverse Agonist with Preclinical Efficacy for Psychoses”
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 533; DOI: https://doi.org/10.1124/jpet.114.06er14
  • You have access
    Correction to “2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter”
    Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 534; DOI: https://doi.org/10.1124/jpet.114.06er14a
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 349 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 349, Issue 3
1 Jun 2014
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
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  • Highlighted Papers
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Neuropharmacology
  • Errata
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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