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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

Protective Effects of Acetaminophen on Ibuprofen-Induced Gastric Mucosal Damage in Rats with Associated Suppression of Matrix Metalloproteinase

Eriko Fukushima, Noriyuki Monoi, Shigeo Mikoshiba, Yutaka Hirayama, Tetsushi Serizawa, Kiyo Adachi, Misao Koide, Motoyasu Ohdera, Michiaki Murakoshi and Hisanori Kato
Journal of Pharmacology and Experimental Therapeutics April 2014, 349 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.210021
Eriko Fukushima
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Noriyuki Monoi
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Shigeo Mikoshiba
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Yutaka Hirayama
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Tetsushi Serizawa
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Kiyo Adachi
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Misao Koide
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Motoyasu Ohdera
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Michiaki Murakoshi
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Hisanori Kato
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
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Article Information

vol. 349 no. 1 165-173
DOI 
https://doi.org/10.1124/jpet.113.210021
PubMed 
24496494

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 26, 2013
  • Accepted February 3, 2014
  • Published online March 13, 2014.

Article Versions

  • Earlier version (February 4, 2014 - 11:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Eriko Fukushima,
  2. Noriyuki Monoi,
  3. Shigeo Mikoshiba,
  4. Yutaka Hirayama,
  5. Tetsushi Serizawa,
  6. Kiyo Adachi,
  7. Misao Koide,
  8. Motoyasu Ohdera,
  9. Michiaki Murakoshi, and
  10. Hisanori Kato
  1. Research and Development Headquarters, Lion Corporation, Kanagawa, Japan (E.F., N.M., S.M., Y.H., T.S., K.A., M.K., M.O., M.M.); and Organization for Interdisciplinary Research Projects, University of Tokyo, Tokyo, Japan (H.K.)
  1. Address correspondence to:
    Eriko Fukushima, Research and Development Headquarters, Lion Corporation, 100, Tajima, Odawara, Kanagawa 256-0811, Japan. E-mail: eriko-f{at}lion.co.jp
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Journal of Pharmacology and Experimental Therapeutics: 349 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 349, Issue 1
1 Apr 2014
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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

Acetaminophen Reduces Ibuprofen-Induced Gastric Damage

Eriko Fukushima, Noriyuki Monoi, Shigeo Mikoshiba, Yutaka Hirayama, Tetsushi Serizawa, Kiyo Adachi, Misao Koide, Motoyasu Ohdera, Michiaki Murakoshi and Hisanori Kato
Journal of Pharmacology and Experimental Therapeutics April 1, 2014, 349 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.210021

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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

Acetaminophen Reduces Ibuprofen-Induced Gastric Damage

Eriko Fukushima, Noriyuki Monoi, Shigeo Mikoshiba, Yutaka Hirayama, Tetsushi Serizawa, Kiyo Adachi, Misao Koide, Motoyasu Ohdera, Michiaki Murakoshi and Hisanori Kato
Journal of Pharmacology and Experimental Therapeutics April 1, 2014, 349 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.210021
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