Research ArticleDrug Discovery and Translational Medicine
No Activation of Human Pregnane X Receptor by Hyperforin-Related Phloroglucinols
Benjamin A. Kandel, Sean Ekins, Kristina Leuner, Wolfgang E. Thasler, Christian Harteneck and Ulrich M. Zanger
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 393-400; DOI: https://doi.org/10.1124/jpet.113.209916
Benjamin A. Kandel
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.)
Sean Ekins
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.)
Kristina Leuner
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.)
Wolfgang E. Thasler
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.)
Christian Harteneck
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.)
Ulrich M. Zanger
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.)
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Research ArticleDrug Discovery and Translational Medicine
Interaction of Phloroglucinols with hPXR
Benjamin A. Kandel, Sean Ekins, Kristina Leuner, Wolfgang E. Thasler, Christian Harteneck and Ulrich M. Zanger
Journal of Pharmacology and Experimental Therapeutics March 1, 2014, 348 (3) 393-400; DOI: https://doi.org/10.1124/jpet.113.209916
Research ArticleDrug Discovery and Translational Medicine
Interaction of Phloroglucinols with hPXR
Benjamin A. Kandel, Sean Ekins, Kristina Leuner, Wolfgang E. Thasler, Christian Harteneck and Ulrich M. Zanger
Journal of Pharmacology and Experimental Therapeutics March 1, 2014, 348 (3) 393-400; DOI: https://doi.org/10.1124/jpet.113.209916
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