Journal of Pharmacology and Experimental Therapeutics: 348 (3)

March 01, 2014; Volume 348,Issue 3

Highlighted Papers

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Direct Vasodilatory Effect of GPBAR1 Agonists in Dog
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 359; DOI: https://doi.org/10.1124/jpet.114.0314HI
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Simvastin Exposure in Nonalcoholic Steatohepatitis
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 359; DOI: https://doi.org/10.1124/jpet.114.0314HIa
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MGM-16, a Novel Dual-Acting µ- and δ-Opioid Agonist
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 359; DOI: https://doi.org/10.1124/jpet.114.0314HIb
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Stimulant-Like Effects of Nicotinic Agonists
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 359; DOI: https://doi.org/10.1124/jpet.114.0314HIc

Behavioral Pharmacology

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Orally Active Opioid μ/δ Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice
Kenjiro Matsumoto, Minoru Narita, Naotaka Muramatsu, Terumi Nakayama, Kaori Misawa, Mariko Kitajima, Kimihito Tashima, Lakshmi A. Devi, Tsutomu Suzuki, Hiromitsu Takayama and Syunji Horie

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 383-392; DOI: https://doi.org/10.1124/jpet.113.208108
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Methamphetamine-Like Discriminative-Stimulus Effects of Nicotinic Agonists
Rajeev I. Desai and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 478-488; DOI: https://doi.org/10.1124/jpet.113.211235

Cardiovascular

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G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a K_Ca1.1 (BK_Ca)–Dependent Mechanism
Ryan M. Fryer, Khing Jow Ng, Suzanne G. Nodop Mazurek, Lori Patnaude, Donna J. Skow, Akalushi Muthukumarana, Kyle E. Gilpin, Roger M. Dinallo, Daniel Kuzmich, John Lord, Sulagna Sanyal, Hui Yu, Christian Harcken, Matthew A. Cerny, Eugene R. Hickey and Louise K. Modis

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 421-431; DOI: https://doi.org/10.1124/jpet.113.210005
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20-HETE Regulates the Angiogenic Functions of Human Endothelial Progenitor Cells and Contributes to Angiogenesis In Vivo
Li Chen, Rachel Ackerman, Mohamed Saleh, Katherine H. Gotlinger, Michael Kessler, Lawrence G. Mendelowitz, John R. Falck, Ali S. Arbab, A. Guillermo Scicli, Michal L. Schwartzman, Jing Yang and Austin M. Guo

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 442-451; DOI: https://doi.org/10.1124/jpet.113.210120

Cellular and Molecular

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Rare Human Nicotinic Acetylcholine Receptor α4 Subunit (CHRNA4) Variants Affect Expression and Function of High-Affinity Nicotinic Acetylcholine Receptors
T. D. McClure-Begley, R. L. Papke, K. L. Stone, C. Stokes, A. D. Levy, J. Gelernter, P. Xie, J. Lindstrom and M. R. Picciotto

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 410-420; DOI: https://doi.org/10.1124/jpet.113.209767

Chemotherapy, Antibiotics, and Gene Therapy

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Improved Apoptotic Cell Death in Drug-Resistant Non–Small-Cell Lung Cancer Cells by Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Based Treatment
L. Gatti, G. Cossa, S. Tinelli, N. Carenini, N. Arrighetti, M. Pennati, D. Cominetti, M. De Cesare, F. Zunino, N. Zaffaroni and P. Perego

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 360-371; DOI: https://doi.org/10.1124/jpet.113.210054
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DW09849, a Selective Phosphatidylinositol 3-Kinase (PI3K) Inhibitor, Prevents PI3K Signaling and Preferentially Inhibits Proliferation of Cells Containing the Oncogenic Mutation p110α (H1047R)
Jia-li Liu, Guo-rui Gao, Xi Zhang, Su-fen Cao, Chen-liang Guo, Xiang Wang, Lin-jiang Tong, Jian Ding, Wen-hu Duan and Ling-hua Meng

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 432-441; DOI: https://doi.org/10.1124/jpet.113.210724

Drug Discovery and Translational Medicine

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No Activation of Human Pregnane X Receptor by Hyperforin-Related Phloroglucinols
Benjamin A. Kandel, Sean Ekins, Kristina Leuner, Wolfgang E. Thasler, Christian Harteneck and Ulrich M. Zanger

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 393-400; DOI: https://doi.org/10.1124/jpet.113.209916

Inflammation, Immunopharmacology, and Asthma

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Anti-Inflammatory and Antinociceptive Action of an Orally Available Nociceptin Receptor Agonist SCH 221510 in a Mouse Model of Inflammatory Bowel Diseases
Marta Sobczak, Anna Mokrowiecka, Adam I. Cygankiewicz, Piotr K. Zakrzewski, Maciej Sałaga, Martin Storr, Radzisław Kordek, Ewa Małecka-Panas, Wanda M. Krajewska and Jakub Fichna

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 401-409; DOI: https://doi.org/10.1124/jpet.113.209825

Metabolism, Transport, and Pharmacogenomics

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Experimental Nonalcoholic Steatohepatitis Increases Exposure to Simvastatin Hydroxy Acid by Decreasing Hepatic Organic Anion Transporting Polypeptide Expression
John D. Clarke, Rhiannon N. Hardwick, April D. Lake, Mark J. Canet and Nathan J. Cherrington

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 452-458; DOI: https://doi.org/10.1124/jpet.113.211284
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Sphingolipid Signaling Reduces Basal P-Glycoprotein Activity in Renal Proximal Tubule
David S. Miller

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 459-464; DOI: https://doi.org/10.1124/jpet.113.210641
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Regulation of UDP-Glucuronosyltransferase 1A1 Expression and Activity by MicroRNA 491-3p
Douglas F. Dluzen, Dongxiao Sun, Anna C. Salzberg, Nate Jones, Ryan T. Bushey, Gavin P. Robertson and Philip Lazarus

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 465-477; DOI: https://doi.org/10.1124/jpet.113.210658

Neuropharmacology

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AS1069562, the (+)-Isomer of Indeloxazine, Exerts Analgesic Effects in a Rat Model of Neuropathic Pain with Unique Characteristics in Spinal Monoamine Turnover
Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Toshihiro Sekizawa, Shuichiro Kakimoto, Mina Tsukamoto, Tomoya Oe, Ryugo Enomoto, Nozomu Hamakawa and Nobuya Matsuoka

Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 372-382; DOI: https://doi.org/10.1124/jpet.113.208686

Notice of Retraction

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Re: Furutani T, Takeyama K-i., Tanabe M, Koutoku H, Ito S, Taniguchi N, Suzuki E, Kudoh M, Shibasaki M, Shikama H, and Kato S (2005) Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target. J Pharmacol Exp Ther 315:545–552; doi:10.1124/jpet.105.087643
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 493; DOI: https://doi.org/10.1124/jpet.114.03er14b

Errata

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Correction to “Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia”
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 489; DOI: https://doi.org/10.1124/jpet.114.03er14
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Correction to “Interactions between μ-Opioid Receptor Agonists and Cannabinoid Receptor Agonists in Rhesus Monkeys: Antinociception, Drug Discrimination, and Drug Self-Administration”
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 490-491; DOI: https://doi.org/10.1124/jpet.114.03er14a
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Correction to “G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a KCa1.1 (BKCa)–Dependent Mechanism”
Journal of Pharmacology and Experimental Therapeutics March 2014, 348 (3) 492; DOI: https://doi.org/10.1124/jpet.114.03er14c

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Notice of Retraction

Errata

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