Research ArticleDrug Discovery and Translational Medicine
Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses
Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R. Frey, Joseph Hesselgesser, Randall L. Halcomb, Grushenka Wolfgang and Daniel B. Tumas
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 96-105; DOI: https://doi.org/10.1124/jpet.113.207878
Abigail Fosdick
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Jim Zheng
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Stefan Pflanz
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Christian R. Frey
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Joseph Hesselgesser
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Randall L. Halcomb
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Grushenka Wolfgang
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
Daniel B. Tumas
Departments of Drug Safety Evaluation (A.F., G.W.), Drug Metabolism (J.Z.), Biology (S.P., C.R.F., D.B.T.), Clinical Virology (J.H.), and Medicinal Chemistry (R.L.H.), Gilead Sciences, Inc., Foster City, California
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Research ArticleDrug Discovery and Translational Medicine
PK and PD of the TLR7 Agonist GS-9620
Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R. Frey, Joseph Hesselgesser, Randall L. Halcomb, Grushenka Wolfgang and Daniel B. Tumas
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 96-105; DOI: https://doi.org/10.1124/jpet.113.207878
Research ArticleDrug Discovery and Translational Medicine
PK and PD of the TLR7 Agonist GS-9620
Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R. Frey, Joseph Hesselgesser, Randall L. Halcomb, Grushenka Wolfgang and Daniel B. Tumas
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 96-105; DOI: https://doi.org/10.1124/jpet.113.207878
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