The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)3(β2)2 Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)2(β2)3 Subtype

J. Brek Eaton; Linda M. Lucero; Harrison Stratton; Yongchang Chang; John F. Cooper; Jon M. Lindstrom; Ronald J. Lukas; Paul Whiteaker

doi:10.1124/jpet.113.208389

Research ArticleNeuropharmacology

The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)₃(β2)₂ Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)₂(β2)₃ Subtype

J. Brek Eaton, Linda M. Lucero, Harrison Stratton, Yongchang Chang, John F. Cooper, Jon M. Lindstrom, Ronald J. Lukas and Paul Whiteaker

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 46-58; DOI: https://doi.org/10.1124/jpet.113.208389

J. Brek Eaton

Division of Neurobiology, Barrow Neurologic Institute, Phoenix, Arizona (J.B.E., L.M.L., H.S., Y.C., R.J.L., P.W.); and Department of Neuroscience, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania (J.F.C., J.M.L.)

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Linda M. Lucero

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Harrison Stratton

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Yongchang Chang

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John F. Cooper

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Jon M. Lindstrom

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Ronald J. Lukas

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Paul Whiteaker

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Journal of Pharmacology and Experimental Therapeutics

Vol. 348, Issue 1

1 Jan 2014

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Research ArticleNeuropharmacology