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Research ArticleCellular and Molecular

Detailed Mechanistic Analysis of Gevokizumab, an Allosteric Anti–IL-1β Antibody with Differential Receptor-Modulating Properties

Hassan Issafras, John A. Corbin, Ira D. Goldfine and Marina K. Roell
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 202-215; DOI: https://doi.org/10.1124/jpet.113.205443
Hassan Issafras
XOMA Corporation, Preclinical Department, Berkeley, California
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John A. Corbin
XOMA Corporation, Preclinical Department, Berkeley, California
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Ira D. Goldfine
XOMA Corporation, Preclinical Department, Berkeley, California
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Marina K. Roell
XOMA Corporation, Preclinical Department, Berkeley, California
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Article Information

vol. 348 no. 1 202-215
DOI 
https://doi.org/10.1124/jpet.113.205443
PubMed 
24194526

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 17, 2013
  • Accepted November 4, 2013
  • Published online December 16, 2013.

Article Versions

  • Earlier version (November 5, 2013 - 10:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hassan Issafras,
  2. John A. Corbin,
  3. Ira D. Goldfine, and
  4. Marina K. Roell
  1. XOMA Corporation, Preclinical Department, Berkeley, California
  1. Address correspondence to:
    Dr. Marina K. Roell, XOMA (U.S.) LLC, 2910 Seventh Street, Berkeley, CA 94710. E-mail: roell{at}xoma.com
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Journal of Pharmacology and Experimental Therapeutics: 348 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 348, Issue 1
1 Jan 2014
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Research ArticleCellular and Molecular

Gevokizumab, an Allosteric Anti–IL-1β-Modulating Antibody

Hassan Issafras, John A. Corbin, Ira D. Goldfine and Marina K. Roell
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 202-215; DOI: https://doi.org/10.1124/jpet.113.205443

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Research ArticleCellular and Molecular

Gevokizumab, an Allosteric Anti–IL-1β-Modulating Antibody

Hassan Issafras, John A. Corbin, Ira D. Goldfine and Marina K. Roell
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 202-215; DOI: https://doi.org/10.1124/jpet.113.205443
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