Research ArticleDrug Discovery and Translational Medicine
Preclinical to Clinical Translation of Tofacitinib, a Janus Kinase Inhibitor, in Rheumatoid Arthritis
Martin E. Dowty, Michael I. Jesson, Sarbani Ghosh, Jamie Lee, Debra M. Meyer, Sriram Krishnaswami and Nandini Kishore
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.209304
Martin E. Dowty
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
Michael I. Jesson
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
Sarbani Ghosh
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
Jamie Lee
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
Debra M. Meyer
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
Sriram Krishnaswami
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
Nandini Kishore
Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.); and Department of Clinical Pharmacology, Pfizer Inc, Pfizer Worldwide Research and Development, Groton, Connecticut (S.K.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Preclinical to Clinical Translation of Tofacitinib in RA
Martin E. Dowty, Michael I. Jesson, Sarbani Ghosh, Jamie Lee, Debra M. Meyer, Sriram Krishnaswami and Nandini Kishore
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.209304
Research ArticleDrug Discovery and Translational Medicine
Preclinical to Clinical Translation of Tofacitinib in RA
Martin E. Dowty, Michael I. Jesson, Sarbani Ghosh, Jamie Lee, Debra M. Meyer, Sriram Krishnaswami and Nandini Kishore
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.209304
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