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Research ArticleMetabolism, Transport, and Pharmacogenomics

Serum- and Glucocorticoid-Regulated Kinase 2 Determines Drug-Activated Pregnane X Receptor to Induce Gluconeogenesis in Human Liver Cells

Saki Gotoh and Masahiko Negishi
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 131-140; DOI: https://doi.org/10.1124/jpet.113.209379
Saki Gotoh
Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
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Masahiko Negishi
Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
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Article Information

vol. 348 no. 1 131-140
DOI 
https://doi.org/10.1124/jpet.113.209379
PubMed 
24204015

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 4, 2013
  • Accepted November 5, 2013
  • Published online December 14, 2013.

Article Versions

  • Earlier version (November 7, 2013 - 05:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Saki Gotoh and
  2. Masahiko Negishi
  1. Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
  1. Address correspondence to:
    Dr. Masahiko Negishi, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709. E-mail: negishi{at}niehs.nih.gov
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Journal of Pharmacology and Experimental Therapeutics: 348 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 348, Issue 1
1 Jan 2014
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Research ArticleMetabolism, Transport, and Pharmacogenomics

SGK2 Determines Drug-Activated PXR to Induce Gluconeogenesis

Saki Gotoh and Masahiko Negishi
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 131-140; DOI: https://doi.org/10.1124/jpet.113.209379

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Research ArticleMetabolism, Transport, and Pharmacogenomics

SGK2 Determines Drug-Activated PXR to Induce Gluconeogenesis

Saki Gotoh and Masahiko Negishi
Journal of Pharmacology and Experimental Therapeutics January 1, 2014, 348 (1) 131-140; DOI: https://doi.org/10.1124/jpet.113.209379
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