Journal of Pharmacology and Experimental Therapeutics: 348 (1)

January 01, 2014; Volume 348,Issue 1

Highlighted Papers

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Modulation of Peripheral μ-Opioid Analgesia by σ₁ Receptors
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0114HI
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A Dopamine Transporter Ligand That Functions as a Cocaine Antagonist
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0114HIa
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Benztropine Analogs as Antagonists of Methamphetamine Self-Administration
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0114HIb
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Inhibition of Renal Potassium Channel Can Cause Diuresis and Natriuresis
Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 1; DOI: https://doi.org/10.1124/jpet.114.0114HIc

Perspectives in Pharmacology

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Analysis of Histamine Receptor Knockout Mice in Models of Inflammation
Detlef Neumann, Erich H. Schneider and Roland Seifert

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 2-11; DOI: https://doi.org/10.1124/jpet.113.204214

Behavioral Pharmacology

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Modulation of Peripheral μ-Opioid Analgesia by σ₁ Receptors
Cristina Sánchez-Fernández, Ángeles Montilla-García, Rafael González-Cano, Francisco Rafael Nieto, Lucía Romero, Antonia Artacho-Cordón, Rosa Montes, Begoña Fernández-Pastor, Manuel Merlos, José Manuel Baeyens, José Manuel Entrena and Enrique José Cobos

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 32-45; DOI: https://doi.org/10.1124/jpet.113.208272
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Pharmacological Characterization of a Dopamine Transporter Ligand That Functions as a Cocaine Antagonist
Rajeev I. Desai, David K. Grandy, Carl R. Lupica and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 106-115; DOI: https://doi.org/10.1124/jpet.113.208538
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Preclinical Efficacy of N-Substituted Benztropine Analogs as Antagonists of Methamphetamine Self-Administration in Rats
Takato Hiranita, Stephen J. Kohut, Paul L. Soto, Gianluigi Tanda, Theresa A. Kopajtic and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 174-191; DOI: https://doi.org/10.1124/jpet.113.208264

Cardiovascular

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Stimulation of G Protein–Coupled Bile Acid Receptor Enhances Vascular Endothelial Barrier Function via Activation of Protein Kinase A and Rac1
Taiki Kida, Keisuke Omori, Masatoshi Hori, Hiroshi Ozaki and Takahisa Murata

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 125-130; DOI: https://doi.org/10.1124/jpet.113.209288
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Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis
Maria L. Garcia, Birgit T. Priest, Magdalena Alonso-Galicia, Xiaoyan Zhou, John P. Felix, Richard M. Brochu, Timothy Bailey, Brande Thomas-Fowlkes, Jessica Liu, Andrew Swensen, Lee-Yuh Pai, Jianying Xiao, Melba Hernandez, Kimberly Hoagland, Karen Owens, Haifeng Tang, Reynalda K. de Jesus, Sophie Roy, Gregory J. Kaczorowski and Alexander Pasternak

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 153-164; DOI: https://doi.org/10.1124/jpet.113.208603

Cellular and Molecular

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A Novel and Potent Inhibitor of Dimethylarginine Dimethylaminohydrolase: A Modulator of Cardiovascular Nitric Oxide
Yohannes T. Ghebremariam, Daniel A. Erlanson and John P. Cooke

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 69-76; DOI: https://doi.org/10.1124/jpet.113.206847
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Detailed Mechanistic Analysis of Gevokizumab, an Allosteric Anti–IL-1β Antibody with Differential Receptor-Modulating Properties
Hassan Issafras, John A. Corbin, Ira D. Goldfine and Marina K. Roell

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 202-215; DOI: https://doi.org/10.1124/jpet.113.205443

Drug Discovery and Translational Medicine

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Chemopreventive Effects of an HDAC2-Selective Inhibitor on Rat Colon Carcinogenesis and APC^min/+ Mouse Intestinal Tumorigenesis
Durgadevi Ravillah, Altaf Mohammed, Li Qian, Misty Brewer, Yuting Zhang, Laura Biddick, Vernon E. Steele and Chinthalapally V. Rao

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 59-68; DOI: https://doi.org/10.1124/jpet.113.208645
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Dopamine and Lipophilic Derivates Protect Cardiomyocytes against Cold Preservation Injury
Christiane Vettel, Maximilia C. Hottenrott, Rahel Spindler, Urs Benck, Peter Schnuelle, Charalambos Tsagogiorgas, Bernhard K. Krämer, Simone Hoeger, Ali El-Armouche, Thomas Wieland and Benito A. Yard

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 77-85; DOI: https://doi.org/10.1124/jpet.113.207001
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Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses
Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R. Frey, Joseph Hesselgesser, Randall L. Halcomb, Grushenka Wolfgang and Daniel B. Tumas

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 96-105; DOI: https://doi.org/10.1124/jpet.113.207878
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Identification of the Antiarrhythmic Drugs Amiodarone and Lorcainide as Potent H3 Histamine Receptor Inverse Agonists
Andria L. Del Tredici, Jian-Nong Ma, Fabrice Piu and Ethan S. Burstein

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 116-124; DOI: https://doi.org/10.1124/jpet.113.208892
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Preclinical to Clinical Translation of Tofacitinib, a Janus Kinase Inhibitor, in Rheumatoid Arthritis
Martin E. Dowty, Michael I. Jesson, Sarbani Ghosh, Jamie Lee, Debra M. Meyer, Sriram Krishnaswami and Nandini Kishore

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 165-173; DOI: https://doi.org/10.1124/jpet.113.209304
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LLY-2707, A Novel Nonsteroidal Glucocorticoid Antagonist That Reduces Atypical Antipsychotic–Associated Weight Gain in Rats
Dana K. Sindelar, Mathew W. Carson, Michelle Morin, Janice Shaw, Robert J. Barr, Anne Need, Jesline Alexander-Chacko, Michael Coghlan and Donald R. Gehlert

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 192-201; DOI: https://doi.org/10.1124/jpet.113.205864

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Bradykinin Contracts Rat Urinary Bladder Largely Independently of Phospholipase C
Carsten Sand and Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 25-31; DOI: https://doi.org/10.1124/jpet.113.208025
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NSAID-Induced Enteropathy: Are the Currently Available Selective COX-2 Inhibitors All the Same?
Matteo Fornai, Luca Antonioli, Rocchina Colucci, Carolina Pellegrini, Giulio Giustarini, Lara Testai, Alma Martelli, Antuela Matarangasi, Gianfranco Natale, Vincenzo Calderone, Marco Tuccori, Carmelo Scarpignato and Corrado Blandizzi

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 86-95; DOI: https://doi.org/10.1124/jpet.113.207118

Inflammation, Immunopharmacology, and Asthma

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Induction of Regulator of G-Protein Signaling 2 Expression by Long-Acting β₂-Adrenoceptor Agonists and Glucocorticoids in Human Airway Epithelial Cells
Neil S. Holden, Tresa George, Christopher F. Rider, Ambika Chandrasekhar, Suharsh Shah, Manminder Kaur, Malcolm Johnson, David P. Siderovski, Richard Leigh, Mark A. Giembycz and Robert Newton

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 12-24; DOI: https://doi.org/10.1124/jpet.113.204586

Metabolism, Transport, and Pharmacogenomics

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Serum- and Glucocorticoid-Regulated Kinase 2 Determines Drug-Activated Pregnane X Receptor to Induce Gluconeogenesis in Human Liver Cells
Saki Gotoh and Masahiko Negishi

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 131-140; DOI: https://doi.org/10.1124/jpet.113.209379
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Nitric Oxide and Interleukin-1β Stimulate the Proteasome-Independent Degradation of the Retinoic Acid Hydroxylase CYP2C22 in Primary Rat Hepatocytes
Choon-myung Lee, Bang-sub Lee, Samuel L. Arnold, Nina Isoherranen and Edward T. Morgan

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 141-152; DOI: https://doi.org/10.1124/jpet.113.209841

Neuropharmacology

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The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)₃(β2)₂ Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)₂(β2)₃ Subtype
J. Brek Eaton, Linda M. Lucero, Harrison Stratton, Yongchang Chang, John F. Cooper, Jon M. Lindstrom, Ronald J. Lukas and Paul Whiteaker

Journal of Pharmacology and Experimental Therapeutics January 2014, 348 (1) 46-58; DOI: https://doi.org/10.1124/jpet.113.208389

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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