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Research ArticleNeuropharmacology

Carbimazole Is an Inhibitor of Protein Synthesis and Protects from Neuronal Hypoxic Damage In Vitro

Cornelius Lehane, Timo Guelzow, Simone Zenker, Anika Erxleben, Christian I. Schwer, Bernd Heimrich, Hartmut Buerkle and Matjaz Humar
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 781-793; DOI: https://doi.org/10.1124/jpet.113.205989
Cornelius Lehane
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Timo Guelzow
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Simone Zenker
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Anika Erxleben
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Christian I. Schwer
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Bernd Heimrich
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Hartmut Buerkle
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Matjaz Humar
Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
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Article Information

vol. 347 no. 3 781-793
DOI 
https://doi.org/10.1124/jpet.113.205989
PubMed 
24049063

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 30, 2013
  • Accepted September 17, 2013
  • Published online November 18, 2013.

Article Versions

  • Earlier version (September 18, 2013 - 06:08).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cornelius Lehane,
  2. Timo Guelzow,
  3. Simone Zenker,
  4. Anika Erxleben,
  5. Christian I. Schwer,
  6. Bernd Heimrich,
  7. Hartmut Buerkle, and
  8. Matjaz Humar
  1. Department of Anesthesiology and Critical Care Medicine (C.L., C.I.S., H.B., M.H.) and Department of General Neurosurgery, Cellular Neurophysiology (T.G.), University Medical Center Freiburg, Freiburg, Germany; and Department of Anatomy and Cell Biology (S.Z., B.H.) and Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences (A.E.), Albert-Ludwigs-University of Freiburg, Freiburg, Germany
  1. Address correspondence to:
    Matjaz Humar, Department of Anesthesiology and Critical Care Medicine, University Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany. E-mail: matjaz.humar{at}uniklinik-freiburg.de
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Journal of Pharmacology and Experimental Therapeutics: 347 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 347, Issue 3
1 Dec 2013
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Research ArticleNeuropharmacology

Carbimazole Induces Phosphorylation of eEF2

Cornelius Lehane, Timo Guelzow, Simone Zenker, Anika Erxleben, Christian I. Schwer, Bernd Heimrich, Hartmut Buerkle and Matjaz Humar
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 781-793; DOI: https://doi.org/10.1124/jpet.113.205989

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Research ArticleNeuropharmacology

Carbimazole Induces Phosphorylation of eEF2

Cornelius Lehane, Timo Guelzow, Simone Zenker, Anika Erxleben, Christian I. Schwer, Bernd Heimrich, Hartmut Buerkle and Matjaz Humar
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 781-793; DOI: https://doi.org/10.1124/jpet.113.205989
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