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Research ArticleMetabolism, Transport, and Pharmacogenomics

Impact of Nicotine Metabolism on Nicotine’s Pharmacological Effects and Behavioral Responses: Insights from a Cyp2a(4/5)bgs-Null Mouse

Lei Li, Kunzhi Jia, Xin Zhou, Sarah E. McCallum, Lindsay B. Hough and Xinxin Ding
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 746-754; DOI: https://doi.org/10.1124/jpet.113.208256
Lei Li
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
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Kunzhi Jia
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
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Xin Zhou
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
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Sarah E. McCallum
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
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Lindsay B. Hough
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
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Xinxin Ding
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
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Article Information

vol. 347 no. 3 746-754
DOI 
https://doi.org/10.1124/jpet.113.208256
PubMed 
24045421

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 22, 2013
  • Accepted September 16, 2013
  • Published online November 18, 2013.

Article Versions

  • Earlier version (September 17, 2013 - 05:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lei Li,
  2. Kunzhi Jia,
  3. Xin Zhou,
  4. Sarah E. McCallum,
  5. Lindsay B. Hough, and
  6. Xinxin Ding
  1. Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany (L.L., K.J., X.Z., X.D.) and Center for Neuropharmacology and Neuroscience, Albany Medical College (S.E.M., L.B.H.), Albany, New York
  1. Address correspondence to:
    Dr. Xinxin Ding, Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201-0509. E-mail: xding{at}wadsworth.org
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Journal of Pharmacology and Experimental Therapeutics: 347 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 347, Issue 3
1 Dec 2013
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Impact of Nicotine Metabolism on Nicotine’s Effects

Lei Li, Kunzhi Jia, Xin Zhou, Sarah E. McCallum, Lindsay B. Hough and Xinxin Ding
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 746-754; DOI: https://doi.org/10.1124/jpet.113.208256

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Impact of Nicotine Metabolism on Nicotine’s Effects

Lei Li, Kunzhi Jia, Xin Zhou, Sarah E. McCallum, Lindsay B. Hough and Xinxin Ding
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 746-754; DOI: https://doi.org/10.1124/jpet.113.208256
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