Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition II: Characterization of Hepatic Elimination by Basolateral, Biliary, and Metabolic Clearance Pathways in Rat Isolated Perfused Liver

Nathan D. Pfeifer; Arlene S. Bridges; Brian C. Ferslew; Rhiannon N. Hardwick; Kim L. R. Brouwer

doi:10.1124/jpet.113.208314

Research ArticleMetabolism, Transport, and Pharmacogenomics

Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition II: Characterization of Hepatic Elimination by Basolateral, Biliary, and Metabolic Clearance Pathways in Rat Isolated Perfused Liver

Nathan D. Pfeifer, Arlene S. Bridges, Brian C. Ferslew, Rhiannon N. Hardwick and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 737-745; DOI: https://doi.org/10.1124/jpet.113.208314

Nathan D. Pfeifer

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina (N.D.P., B.C.F., K.L.R.B.); and Department of Pathology (A.S.B.) and Curriculum in Toxicology (R.N.H., K.L.R.B.), School of Medicine, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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Arlene S. Bridges

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Brian C. Ferslew

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Rhiannon N. Hardwick

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Kim L. R. Brouwer

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Journal of Pharmacology and Experimental Therapeutics

Vol. 347, Issue 3

1 Dec 2013

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Rosuvastatin Disposition in Rat Isolated Perfused Liver

Nathan D. Pfeifer, Arlene S. Bridges, Brian C. Ferslew, Rhiannon N. Hardwick and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 737-745; DOI: https://doi.org/10.1124/jpet.113.208314

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Rosuvastatin Disposition in Rat Isolated Perfused Liver

Nathan D. Pfeifer, Arlene S. Bridges, Brian C. Ferslew, Rhiannon N. Hardwick and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 737-745; DOI: https://doi.org/10.1124/jpet.113.208314

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