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Research ArticleMetabolism, Transport, and Pharmacogenomics

Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition I: Characterization of Basolateral Versus Biliary Clearance Using a Novel Protocol in Sandwich-Cultured Hepatocytes

Nathan D. Pfeifer, Kyunghee Yang and Kim L. R. Brouwer
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 727-736; DOI: https://doi.org/10.1124/jpet.113.207472

Article Information

vol. 347 no. 3 727-736
DOI 
https://doi.org/10.1124/jpet.113.207472
PubMed 
24023367
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received June 26, 2013
  • Accepted September 3, 2013
  • Published online November 18, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nathan D. Pfeifer,
  2. Kyunghee Yang, and
  3. Kim L. R. Brouwer
  1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  1. Address correspondence to:
    Kim L. R. Brouwer, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB #7569, Chapel Hill, NC 27599-7569. E-mail: kbrouwer{at}email.unc.edu
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Hepatic Basolateral Efflux of Rosuvastatin

Nathan D. Pfeifer, Kyunghee Yang and Kim L. R. Brouwer
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 727-736; DOI: https://doi.org/10.1124/jpet.113.207472
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