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Research ArticleDrug Discovery and Translational Medicine

Establishment of an X-ray Irradiation-Induced Glossitis Model in Rats: Biphasic Elevation of Proinflammatory Cytokines and Chemokines

Takako Nakashima, Naoya Uematsu, Masafumi Shibamori, Kazushi Sakurai and Tatsuhiro Ishida
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 660-668; DOI: https://doi.org/10.1124/jpet.113.208405
Takako Nakashima
Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.)
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Naoya Uematsu
Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.)
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Masafumi Shibamori
Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.)
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Kazushi Sakurai
Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.)
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Tatsuhiro Ishida
Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.)
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Article Information

vol. 347 no. 3 660-668
DOI 
https://doi.org/10.1124/jpet.113.208405
PubMed 
24060545

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 4, 2013
  • Accepted September 23, 2013
  • Published online November 18, 2013.

Article Versions

  • Earlier version (September 23, 2013 - 11:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Takako Nakashima,
  2. Naoya Uematsu,
  3. Masafumi Shibamori,
  4. Kazushi Sakurai, and
  5. Tatsuhiro Ishida
  1. Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan (T.N., T.I.); and Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (T.N., N.U., M.S., K.S.)
  1. Address correspondence to:
    Takako Nakashima, Third Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, Japan. E-mail: Nakashima.Takako{at}otsuka.jp
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Journal of Pharmacology and Experimental Therapeutics: 347 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 347, Issue 3
1 Dec 2013
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Research ArticleDrug Discovery and Translational Medicine

Establishment of X-ray Irradiation-Induced Glossitis Model

Takako Nakashima, Naoya Uematsu, Masafumi Shibamori, Kazushi Sakurai and Tatsuhiro Ishida
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 660-668; DOI: https://doi.org/10.1124/jpet.113.208405

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Research ArticleDrug Discovery and Translational Medicine

Establishment of X-ray Irradiation-Induced Glossitis Model

Takako Nakashima, Naoya Uematsu, Masafumi Shibamori, Kazushi Sakurai and Tatsuhiro Ishida
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 660-668; DOI: https://doi.org/10.1124/jpet.113.208405
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