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Research ArticleDrug Discovery and Translational Medicine

Kinetics of 5-HT2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, Huong T.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing and Ibragim Gaidarov
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 645-659; DOI: https://doi.org/10.1124/jpet.113.207670

Article Information

vol. 347 no. 3 645-659
DOI 
https://doi.org/10.1124/jpet.113.207670
PubMed 
24049061
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 1, 2012
  • Accepted September 17, 2013
  • Published online November 18, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David J. Unett,
  2. Joel Gatlin,
  3. Todd L. Anthony,
  4. Daniel J. Buzard,
  5. Steve Chang,
  6. Chuan Chen,
  7. Xiaohua Chen,
  8. Huong T.-M. Dang,
  9. John Frazer,
  10. Minh K. Le,
  11. Abu J. M. Sadeque,
  12. Charles Xing, and
  13. Ibragim Gaidarov
  1. Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
  1. Address correspondence to:
    Dr. David J. Unett, Receptor Pharmacology Department, Arena Pharmaceuticals, Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121. E-mail: dunett{at}arenapharm.com
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Research ArticleDrug Discovery and Translational Medicine

5-HT2B Agonist Kinetics and Their Functional Consequences

David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, Huong T.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing and Ibragim Gaidarov
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 645-659; DOI: https://doi.org/10.1124/jpet.113.207670
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