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Research ArticleDrug Discovery and Translational Medicine

Kinetics of 5-HT2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, Huong T.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing and Ibragim Gaidarov
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 645-659; DOI: https://doi.org/10.1124/jpet.113.207670
David J. Unett
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Joel Gatlin
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Todd L. Anthony
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Daniel J. Buzard
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Steve Chang
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Chuan Chen
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Xiaohua Chen
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Huong T.-M. Dang
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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John Frazer
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Minh K. Le
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Abu J. M. Sadeque
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Charles Xing
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Ibragim Gaidarov
Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California
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Journal of Pharmacology and Experimental Therapeutics: 347 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 347, Issue 3
1 Dec 2013
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Research ArticleDrug Discovery and Translational Medicine

5-HT2B Agonist Kinetics and Their Functional Consequences

David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, Huong T.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing and Ibragim Gaidarov
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 645-659; DOI: https://doi.org/10.1124/jpet.113.207670

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Research ArticleDrug Discovery and Translational Medicine

5-HT2B Agonist Kinetics and Their Functional Consequences

David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, Huong T.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing and Ibragim Gaidarov
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 645-659; DOI: https://doi.org/10.1124/jpet.113.207670
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