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Research ArticlePerspectives in Pharmacology

Nonhuman Primates: Translational Models for Predicting Antipsychotic-Induced Movement Disorders

Roger D. Porsolt, Vincent Castagné, Eric Hayes and David Virley
Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 542-546; DOI: https://doi.org/10.1124/jpet.113.207209
Roger D. Porsolt
Porsolt Research Center, Porsolt SAS (France), Le Genest-Saint-Isle, France
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Vincent Castagné
Porsolt Research Center, Porsolt SAS (France), Le Genest-Saint-Isle, France
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Eric Hayes
Porsolt Research Center, Porsolt SAS (France), Le Genest-Saint-Isle, France
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David Virley
Porsolt Research Center, Porsolt SAS (France), Le Genest-Saint-Isle, France
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Abstract

Repeated haloperidol treatment administered to nonhuman primates (NHPs) over several months or even years leads to the gradual appearance of drug-induced dystonic reactions in the orofacial region (mouth opening, tongue protrusion or retraction, bar biting) and in the whole body (writhing of the limbs and trunk, bar grasping). The propensity of antipsychotics to induce dystonia in NHPs is not correlated with their propensity to induce catalepsy in rodents, suggesting that the two types of effects are dissociated and may represent distinct aspects of the extrapyramidal symptoms induced by antipsychotics. In view of the clear homology to clinically observed phenomena, antipsychotic-induced dystonias in antipsychotic-primed NHPs would appear to possess a high degree of translational validity. These NHP phenomena could therefore serve as a useful model for predicting the occurrence of similar abnormal movements with novel substances developed for the treatment of schizophrenia or other psychotic disorders. Moreover, the NHP dystonia model could possibly serve as a biomarker for substances that will eventually cause tardive dyskinesia in patients.

Footnotes

    • Received June 14, 2013.
    • Accepted September 12, 2013.
  • dx.doi.org/10.1124/jpet.113.207209.

  • Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 347 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 347, Issue 3
1 Dec 2013
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Research ArticlePerspectives in Pharmacology

Antipsychotic-Induced Movement Disorders in NHPs

Roger D. Porsolt, Vincent Castagné, Eric Hayes and David Virley
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 542-546; DOI: https://doi.org/10.1124/jpet.113.207209

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Research ArticlePerspectives in Pharmacology

Antipsychotic-Induced Movement Disorders in NHPs

Roger D. Porsolt, Vincent Castagné, Eric Hayes and David Virley
Journal of Pharmacology and Experimental Therapeutics December 1, 2013, 347 (3) 542-546; DOI: https://doi.org/10.1124/jpet.113.207209
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  • Article
    • Abstract
    • Introduction
    • Animal Models of Antipsychotic-Induced Parkinsonism
    • Animal Models of Antipsychotic-Induced Akathisia
    • Animal Models of Antipsychotic-Induced Dystonia
    • Catalepsy in Rats versus Dystonia in NHPs
    • Animal Models of Antipsychotic-Induced Tardive Dyskinesia
    • Conclusions
    • Acknowledgments
    • Authorship Contributions
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