Table of Contents

Drug Discovery and Translational Medicine

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  Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors

  Tsutomu Akama, Chen Dong, Charlotte Virtucio, David Sullivan, Yasheen Zhou, Yong-Kang Zhang, Fernando Rock, Yvonne Freund, Liang Liu, Wei Bu, Anne Wu, Xiao-Qing Fan and Kurt Jarnagin

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 615-625; DOI: https://doi.org/10.1124/jpet.113.207662
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  cGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from Acute Kidney Injury

  Ryan M. Whitaker, Lauren P. Wills, L. Jay Stallons and Rick G. Schnellmann

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 626-634; DOI: https://doi.org/10.1124/jpet.113.208017
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  Combined Analysis of Pharmacokinetic and Efficacy Data of Preclinical Studies with Statins Markedly Improves Translation of Drug Efficacy to Human Trials

  E. van de Steeg, R. Kleemann, H. T. Jansen, W. van Duyvenvoorde, E. H. Offerman, H. M. Wortelboer and J. DeGroot

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 635-644; DOI: https://doi.org/10.1124/jpet.113.208595
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  Kinetics of 5-HT_2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration

  David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, Huong T.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing and Ibragim Gaidarov

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 645-659; DOI: https://doi.org/10.1124/jpet.113.207670
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  Establishment of an X-ray Irradiation-Induced Glossitis Model in Rats: Biphasic Elevation of Proinflammatory Cytokines and Chemokines

  Takako Nakashima, Naoya Uematsu, Masafumi Shibamori, Kazushi Sakurai and Tatsuhiro Ishida

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 660-668; DOI: https://doi.org/10.1124/jpet.113.208405
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  Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced Cell Death

  John S. Lazo, Elizabeth R. Sharlow, Michael W. Epperly, Ana Lira, Stephanie Leimgruber, Erin M. Skoda, Peter Wipf and Joel S. Greenberger

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 669-680; DOI: https://doi.org/10.1124/jpet.113.208421
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  Differential Interaction of Neuroleptics with Apomorphine-Induced Behavior in Rats as a Function of Changing Levels of Dopamine Receptor Stimulation

  Anton A.H.P. Megens, Herman M.R. Hendrickx, Hilde Lavreysen and Xavier Langlois

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 681-696; DOI: https://doi.org/10.1124/jpet.113.207506
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  The Protease Activated Receptor 2 (PAR2) Polymorphic Variant F240S Constitutively Activates PAR2 Receptors and Potentiates Responses to Small-Molecule PAR2 Agonists

  Jian-Nong Ma and Ethan S. Burstein

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 697-704; DOI: https://doi.org/10.1124/jpet.113.208744
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  Molecular Pharmacology and Ligand Docking Studies Reveal a Single Amino Acid Difference between Mouse and Human Serotonin 5-HT2A Receptors That Impacts Behavioral Translation of Novel 4-Phenyl-2-dimethylaminotetralin Ligands

  Clinton E. Canal, Tania Cordova-Sintjago, Yue Liu, Myong S. Kim, Drake Morgan and Raymond G. Booth

  Journal of Pharmacology and Experimental Therapeutics December 2013, 347 (3) 705-716; DOI: https://doi.org/10.1124/jpet.113.208637